Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Without treatment, autoimmune hepatitis (AIH) often leads to cirrhosis, liver failure, and in some cases, death. However, the pathogenesis of AIH remains incompletely understood. Here, we explored the relationship between differentially expressed circRNAs (DECs) and development of AIH by obtaining an expression profile of DECs in concanavalin A-induced AIH mouse model by microarray. In total, we identified 27 DECs; the host genes of these DECs were annotated with 140 GO terms and 19 pathways, revealing potential roles in the metabolism of cellular ions and regulation of protein expression, as well as possible involvement in endocytosis and apoptosis. We constructed a circRNA-miRNA network which was used to infer that a mmu_circ_0001520/mmu-miR-193b-3p/MAPK10 network may be associated with the occurrence of AIH. These findings may help lay the foundation for validation of the potential roles of circRNAs in AIH.
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PMID:Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: Preliminary screening and comprehensive functional analysis. 3296 91