Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Excretion of oxalic acid in urine was measured in 28 healthy and 97 patients with gastrointestinal diseases. We found significantly higher values in the following groups: patients after resection of parts of the small intestine, patients with sprue and other diseases with malabsorption, patients with M. Crohn of the small intestine, colitis ulcerosa and granulomatosa, patients with chronical diseases of the pancreas gland and patients with cirrhosis of the liver. In 4 patients after resection of parts of the small intestine or pancreas urolithiasis could be verified. Reduction of fat and food without ballast reduced the excretion of oxalic acid in urine. Hyperoxaluria correlied significantly with the following parameters: excretion of fat in feces, exhalation of 14CO2 in the glykocholate breath test, resorption of vit. B12 and the length of resected small intestine. This form of hyperoxaluria is caused by hyperresorption of oxalic acid from food. The mechanism of this hyperresorption is not clarified yet, an important factor seems to be ill resorption of fat.
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PMID:[Hyperoxaluria in intestinal and liver diseases]. 83 13

It is reported on the estimation of the vitamin A absorption test in 17 patients with chronic liver diseases, 26 patients with diseases of the extrahepatic biliary system, and in 12 patients with diseases of the stomach. In the latter there are no changes in the vitamin A test. On the contrary patients with diseases of the liver and biliary system show differences in the serum vitamin A levels. A separate consideration of active liver cirrhosis and active cholangitis indicates individualities in the constellation of the 3 and 6 hour values after vitamin A ingestion: in liver cirrhosis the first value is normal while the 6 hour value seems significant lowered so that the maximum vitamin A concentration is found near 3 hours. In active cholangitis both values are reduced, the first one more than the second one. The reason is to be seen in a decrease of the conjugated bile acids, whereas in the group of liver diseases an interpretation is somewhat problematic. It is to discuss whether these results depend on the development of portal hypertension, while the intestinal absorption seems normal and liver damage only of secondary importance. The fact that this test is influenced by diseases of the liver and biliary system shortens its significance as a screening test for malabsorption or maldigestion though a further differentiation between sprue and pancreatic insufficiency seems possible.
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PMID:[Vitamin A absorption test. II. Diseases of the liver, the extrahepatic biliary system and the stomach (author's transl)]. 118 79

Numerous complications can occur in celiac disease, nutritional (growth failure in children, malnutrition, vitamin deficiencies), hematologic (anaemia), bone disease (osteoporosis, fracture), gynaecologic (hypo fertility), cardiovascular (coronaropathy, venous thrombosis), neurological (peripheral neuropathy), hepatic (cytolysis, cirrhosis). Celiac disease is associated with an increased risk of autoimmune diseases (type 1 diabetes, thyroiditis), and cancer (upper digestive tract, hepatocellular carcinoma, lymphoma). The main digestive complications are microscopic colitis and refractory sprue, which are resistant to gluten-free diet. It can be associated with a monoclonal proliferation of intraepithelial lymphocytes (type 2 refractory sprue), which may be considered as a cryptic lymphoma and can lead to invasive T lymphoma, which occurs in one celiac patient in 1000. Gluten-free diet protects from the occurrence of most complications and correct the over-mortality related to these complications.
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PMID:[Complications of celiac disease]. 2162 50