Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Authors give results about 60 laparoscopies in negro immigrants. If one excepts isolated cases of liver cirrhosis, hepatoma, staphylococcic liver abscess, lymphosarcoma or schistosomiasis of the peritoneum and twelve normal laparoscopies, the most frequent diagnosis in this peculiar group is peritoneal and/or liver tuberculosis (21 cases). Endoscopic aspects of hepato-splenic schistosomiasis are summarized. Interest of liver and/or peritoneal biopsies is underlined. Problem of liver granulomatosis may be ambiguous between schistosomiasis and tuberculosis.
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PMID:[Laparoscopy in black African immigrants. Apropos of 60 cases]. 21 15

A case of a 49 year old patient suffering from ulcerative colitis and chronic hepatitis with cirrothic transformation is presented who under prolonged immunosuppressive treatment with azathioprine 50 mg daily and 10 mg daily of prednisone developed Hodgkins disease whose diagnosis was at the autopsy. The association between hepatic cirrhosis and lymphoproliferative disorders such as lymphosarcoma and lymphatic leukemia were already described (19,20). Recently, an article was published on a similar case to ours (23) in which the patient, suffering from chronic hepatopathy submitted to azathioprine and corticoids, developed Hodgkin's disease. The link between ulcerative colitis, the chronic hepatopathy and the development of Hodgkin's disease that could have arisen as a consequence of the prolonged immunosuppressive treatment are discussed. The apparition of malignancies in patients submitted to immunosuppression owing to renal transplantation are compared with the apparition of malignancies in patients submitted to immunosuppression because of a number of other diseases.
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PMID:[Hodgkin's disease developing in the course of a chronic liver disease with ulcerative colitis immunosuppressed with azathioprine]. 50 43

Seven patients suffering from liver cirrhosis combined with lymphoproliferative diseases: chronic lymphoid leukemia (n = 4), lymphosarcoma (n = 3) were placed under observation. Viral etiology of liver cirrhosis was established in 4 patients (HBV markers were revealed in the serum in 2 and in liver tissue in 1) and was assumed in 3 patients (the lack in the anamnesis of other hepatotropic factors; multilobular form of liver cirrhosis). In 5 patients, the lymphoproliferative disease was diagnosed 2-30 years after the appearance of the symptoms of chronic diffuse liver disease. In 2 patients liver cirrhosis and hemoblastosis showed up simultaneously. The role of hepatitis viruses, HBV in particular, in the onset of lymphoproliferative diseases is under discussion.
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PMID:[Liver cirrhosis and lymphoproliferative diseases]. 144 Mar 37

In 35 dogs with spontaneous hepatobiliary liver disease the kinetics and the sources of bilirubin were quantified. The disorders were extrahepatic bile duct obstruction (n = 4), fulminant hepatitis (n = 2), (sub)acute hepatitis (n = 5), chronic active hepatitis (CAH) with cirrhosis (n = 6), hepatic lymphosarcoma (n = 5), centrizonal necrosis secondary to haemolytic anaemia (n = 6) and other (n = 2). The plasma disappearance of [3H]bilirubin was analyzed with a two-compartment model in all dogs. The ratio early labeled/late labeled bilirubin was determined by measuring the incorporation of [14C]glycine into erythrocyte haem and faecal stercobilin. By introducing this relation in the model analysis the bilirubin production rates from erythrocyte destruction (PE), ineffective erythropoiesis (PI) and hepatic haemoprotein (PL) could be quantified. Total bilirubin turnover was increased in both primary haemolytic disease and most cases of hepatobiliary disease. Erythrocyte survival was reduced in all cases but one. The bilirubin clearance was impaired to 30-50% of the normal value in most cases of hepatobiliary disease and also in primary haemolysis. In dogs with fulminant hepatitis, and cirrhosis with or without CAH, the clearance rates were reduced to values below 15% of normal. In these dogs both an impaired clearance and an increased production were important determinants of hyperbilirubinaemia. In other cases plasma bilirubin was primarily determined by increased production. These clearances and production rates were similar in haemolysis and in many cases of primary hepatobiliary disease. The hepatic haemoprotein turnover was quite variable in all subgroups, ranging from 1-74% of the total bilirubin turnover.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:The origins and kinetics of bilirubin in dogs with hepatobiliary and haemolytic diseases. 150 35

The diagnostic value of serum gamma-glutamyl transferase (GGT) activity and serum alkaline phosphatase (ALP) activity in the detection of liver disease in the cat (n = 69) was compared. On the basis of histologic examination of the liver, cats were assigned to 8 groups: group 1--complete extrahepatic bile duct obstruction (n = 5), group 2--cholangiohepatitis-cholangitis syndrome (n = 11), group 3--hepatic lipidosis (n = 15), group 4--neoplasia, including lymphosarcoma and myeloproliferative disease (n = 9), group 5--hepatic necrosis (n = 7), group 6--cirrhosis (n = 3), group 7--portosystemic vascular anomaly (n = 4), and group 8--miscellaneous (n = 15). Cats assigned to group 8 lacked substantial histologic abnormalities of the liver. The mean value +/- SD of GGT in 20 clinically normal cats was 0.44 +/- 0.26 IU/L. The highest GGT activity in clinical patients developed in groups 1, 2, and 6. The highest ALP activity developed in groups 1 to 4. Significant correlations between GGT and ALP activities were detected only in groups 2 (P less than 0.001) and 5 (P less than 0.10). Among 54 cats with hepatic disease, only 11% had both the GGT and ALP activities within the normal ranges. Comparatively, 52% had ALP activities within the normal range, and 17% had GGT activities within the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Diagnostic value of serum gamma-glutamyl transferase and alkaline phosphatase activities in hepatobiliary disease in the cat. 287 43

The histological findings in 14 cases of brucellosis are described. Unusual findings include the occurrence of brucellosis in a patient with Hodgkin's disease and in another with lymphosarcoma. A patient with hepatic cirrhosis apparently due to brucellosis is included in the series.
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PMID:Histological findings in human brucellosis. 563 72