Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Personal experience of 31 patients suffering from intractable ascites due to advanced liver cirrhosis between 1978 and 1987 is reported. Seventeen patients were selected for a peritoneojugular shunt: in 3 patients the Le Veen shunt was performed and in 14 the Denver shunt was preferred. The high postoperative morbidity and mortality due to liver failure, DIC, hepatorenal syndrome, bleeding, sepsis and cerebral thrombosis is pointed out. Careful selection of patients to be submitted to this surgical procedure is essential because of the high morbidity due to ascites reinfusion. DIC has to be diagnosed as soon as possible and, when severe, the prompt interruption of the peritoneojugular shunt is mandatory.
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PMID:[The Denver peritoneojugular shunt. Current indications]. 272 37

In order to study the role and metabolism of high density lipoprotein (HDL) subfractions, the serum HDL2-cholesterol (HDL2-C) and HDL3-cholesterol (HDL3-C) were measured by the new method using high performance liquid chromatography in the normal subjects and patients with various diseases. It was highly characteristic that the serum HDL3-C levels of the patients with liver cirrhosis (LC) were remarkably lower than those of the normal subjects. The result suggests that HDL3 may be produced in the liver. Both the serum HDL2-C and HDL3-C levels were significantly lower in the patients with coronary heart disease (CHD) or cerebral thrombosis (CT) than in the normal subjects (P less than 0.001). In the normal subjects, the changes in the serum HDL-cholesterol (HDL-C) levels were mainly due to those in the serum HDL2-C levels. On the other hand, in the patients with atherosclerotic diseases (CHD, or CT) the changes in the serum HDL-C levels Were attributed to those of both the serum HDL2-C and HDL3-C levels. So it is suggested that in the atherosclerotic diseases, in which the HCL-C is usually lower, the HDL3-C also may play an important role in the regulation of the total HDL-C and its anti-atherogenetic effect.
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PMID:Role and metabolism of high density lipoprotein subfractions--analysis of serum HDL2-cholesterol and HDL3-cholesterol in patients with various diseases by high performance liquid chromatography. 695 38

A 58-year-old male, known to have hepatitis C virus (HCV), presented with intermittent headaches and left-sided sensorimotor symptoms. There were no focal neurological deficits on examination. Electrocardiogram was unremarkable. Computed tomography angiography head and neck displayed extracranial right internal carotid artery occlusion. Magnetic resonance imaging showed right cortical vein thrombosis, with hemorrhagic infarction. Echocardiography with bubble study was unremarkable. Hypercoagulable workup was significant for protein S deficiency. He was treated with warfarin for 6 months. Repeat protein S levels remained low 9 months later. The coexistence of arterial and venous thrombotic events gives rise to a limited differential. In this case, it may be related to chronic HCV infection. The underlying pathogenesis is not clear; however, it is possible the patient had chronic high-grade internal carotid artery stenosis, which occluded leading to his presenting symptoms. The cortical vein thrombosis is likely an incidental finding here. The extent by which HCV contributed to the cerebral thrombosis and carotid artery occlusion in our case is not clear; however, the hypercoagulable and atherosclerotic properties of the virus cannot be disregarded. The virus can promote carotid atherosclerosis and cerebral venous thrombosis as well as other venous and arterial thromboembolic events. Furthermore, HCV is associated with impaired venous flow and procoagulant properties, which can fuel a hypercoagulable state. Also of note cirrhosis is associated with protein S deficiency. We recommend considering an underlying hypercoagulable state including both arterial and venous thrombosis in HCV infection.
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PMID:Coexistent Ipsilateral Internal Carotid Artery Occlusion and Cerebral Venous Thrombosis in Hepatitis C. 2934 91