Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is a study of alcoholic mortality in which time, cause, and age at death were variables of critical interest. Five cohorts of 100 members each were followed 12, 11, 9, 6, and 4 years. A total of 133 cases were located as deceased. The overall case fatality rate (CFR) was .0371. Higher CFR's were observed in years 1 to 6. Cardiovascular disease, violence (homicide, suicide, accidental), cirrhosis, carcionomas, and acute intoxication were the leading causes of death. Violent deaths were more prevalent in younger admission age groups. The cardiovascular/other ratio increased in older admission age groups.
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PMID:Alcoholic mortality: a 12-year follow-up. 74 74

To estimate the impact of intravenous drug use (IVDU) on mortality in the general population of young adults in Rome, Italy, the Population Attributable Risk (PAR) was calculated for the overall and cause-specific mortality in the 15-34 years age group. Relative risks were derived from a previous historical cohort study on mortality among 4200 intravenous drug users (IVDUs) in Rome, in which increased mortality from cardiovascular, respiratory, and gastrointestinal diseases as well as from violence, overdose and AIDS had been observed. The prevalence of the risk factor (i.e. the proportion of IVDUs) in the general population was estimated using the 'multiplier formula' and 'capture-recapture' methods. The proportion of all deaths attributable to IVDU in the 15-34 age group in the Roman population was 16% and 9% in males and females, respectively. The cause-specific attributable proportions were 66% for endocarditis and 37% for cirrhosis in males, and 36% for endocarditis and pneumonia in females. These findings further document the relevant health consequences of IVDU on the general population of a large metropolitan area.
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PMID:The impact of intravenous drug use on mortality of young adults in Rome, Italy. 149 77

A historical cohort study was carried out in Rome to examine overall and cause-specific mortality among intravenous drug users (IVDUs). A total of 4200 IVDUs (3411 men and 789 women) enrolled in methadone treatment centers between 1980 and 1988 were studied. There were 239 deaths during the follow-up period. The overall SMR was 10.10 in the entire cohort (95% confidence interval, 8.86-11.47), 9.30 in males and 18.07 in females. A large excess of mortality in both sexes was found for infectious, circulatory, respiratory, and digestive diseases as well as for violence, overdose, AIDS, and unknown or ill-defined causes. Tumors and suicide were excessive only in males. Deaths due to drug overdose, violence or trauma, and cirrhosis accounted for 63.6%, AIDS for 7.1%, endocarditis and other bacterial infections for 7.1%, and neoplasms for 3.8% of total mortality. These findings document serious health consequences of drug abuse in Italy.
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PMID:Mortality of intravenous drug users in Rome: a cohort study. 192 19

Overdrinking among young people tends to be episodic. It leads to accidents and violence rather than to cirrhosis or alcoholism. Preventive efforts should focus on the problem as it actually presents.
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PMID:Alcohol and youth. 229 79

Alcohol consumption is an important element in the epidemiologic profile of Mexico. This can be confirmed observing the increased per capita consumption of certain alcoholic beverages (like beer and wine), alcohol related medical problems (e.g. liver cirrhosis), social problems (i.e. violence) and by the data provided by household surveys of prevalence of alcohol consumption in Mexico since the 60's. The population's consumption of alcoholic beverages has generated concern, as the Simple Distribution Theory (SDT) predicts that an increment in the per capita alcohol consumption is likely to be accompanied by an increment of heavy drinkers. This increment is, then, related to a theoretical increment in alcohol related damages. In order to partially test the SDT data from a series of surveys done in the country, six surveys of the 70's were used. Those surveys were executed in six cities, the capital of five states and the capital of the Republic, with a comparable methodology and definition of alcohol consumption. We used prevalence data of heavy drinkers in those cities as an independent variable for a series of medical and social problems, in a multiple-group comparison study. In general, the results do not support the SDT in the case of mortality by liver cirrhosis, suicide and traffic deaths, or for alcohol related offenses at the Federal Courts. Nevertheless, the results seem to support the SDT for some groups in Common Court offenses and for the rate of traffic accidents. In a comparison with other independent variables (prevalence of abstainers, per capita bars, illiteracy, unemployment, and population density), the prevalence of heavy drinkers and population density were the best. Both obtained the largest number of statistically significant correlations with the problems studied. For the prevalence of heavy drinkers some of those correlations were in the inverse sense as predicted by the SDT.
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PMID:[The prevalence of chronic drinkers in Mexico: an ecologic analysis]. 258 69

We examined the mortality experience of 3,479 male Dow Canada employees who were employed at Sarnia Division for at least 12 continuous months during the years 1945 through 1983, utilizing the Canadian Mortality Data Base maintained by Statistics Canada, covering 1950-1984. We analyzed cause-specific mortality using male, age and calendar-year-adjusted death rates for Canada and Ontario. Total mortality was significantly below expectation whether the entire follow-up period (240 observed vs. 366.9 expected) or a 15-year latency period (171 observed vs. 290.4 expected) was considered. Statistically significant fewer observed deaths were found for all respiratory cancer, cancer of the bronchus and lung, circulatory disease, ischemic heart disease, cerebrovascular disease, digestive disease, cirrhosis and other liver disease and deaths due to accidents, poisonings and violence. The observation of three deaths due to mesothelioma, a rare cancer often associated with asbestos exposure, was a significant finding as was a statistically significant elevation of observed deaths in the category "other forms of heart disease".
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PMID:An historical prospective mortality study of the Sarnia Division of Dow Chemical Canada Inc., Sarnia, Ontario (1950-1984). 261 43

Three hundred eighty-three alcoholics, who had at least once been ordered supervision or compulsory treatment at an institution for alcoholics by the Temperance Board, were compared with 383 other alcoholics matched for age and sex. All the alcoholics were first admitted to the Department of Psychiatry, University Hospital, Lund, during the years 1949 to 1969 and followed up until January 1, 1981. They were systematically rated concerning symptoms and etiological factors at first admission. According to a stepwise logistic regression analysis, the following initial symptoms were positively associated with later compulsory treatment: slight cerebral dysfunction/personality change, antisociality/criminality, and impaired social and work performance. Social pressure/responsibility/conflict, slight depression, and continuous drinking were positively associated with the controls. There were 168 deaths in the compulsory treatment group and 124 in the control group (p less than 0.01). The excess deaths in the compulsory treatment group were mainly caused by accidents, poisoning, and violence (21 cases) and sudden cardiac death (10 cases), while there were no differences concerning alcohol-related neoplasms and liver cirrhosis. The compulsory treatment group had a worse long-term social adjustment. The findings indicate that compulsory treatment was related to behavioral patterns showing a stability over time, supporting the validity of subclassification of alcoholics using social data.
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PMID:Alcoholics committed to treatment: a prospective long-term study of behavioral characteristics, mortality, and social adjustment. 327 54

Hospital admission histories were compared for groups of Navy enlisted men identified as alcohol abusers or controls during the later years of their service careers. The alcohol abuse group had a higher mean number of hospital admissions per year and a higher mean number of days hospitalized per year than did the control group. Highest admission rates for both abusers and controls were reported in two major diagnostic categories, first, accidents, poisoning, and violence, and second, diseases of the digestive system. The rates for alcohol abusers exceeded those of controls in these and several additional diagnostic categories including mental disorders where the greatest disparity in rates of hospitalization was noted. The greatest differences in rates of specific illness between abusers and controls were observed for cirrhosis of the liver and diseases of the pancreas. Reasons for higher illness rates other than alcohol abuse were not apparent from available data.
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PMID:Alcohol-related morbidity among older career navy men. 711 32

The health of Whites in South Africa in 1970 was poorer than that of the population of England and Wales, judged by the higher mortality rates (MRs) for all causes of death of White South Africans, for all ages combined and for every age interval from infancy to old age. Two groups of causes of disease were the main reasons for the poorer health of White South Africans: (i) 'diseases of the circulatory system' accounted for 50-60% of the higher MRs for all causes of death; ischaemic heart disease and cerebrovascular disease were the two main causes of circulatory deaths, and MRs for these two diseases were much higher in White South Africans than in England and Wales; (ii) 'accidents, poisonings and violence' accounted for 38% of the higher MRs for all causes of death in males and for 17% of those in females. Motor vehicle accidents and suicide were the main causes of accidental deaths, MRs of White South Africans being much higher than those in England and Wales. These MRs were among the highest in the world. Other diseases which contributed, to a small extent, to the poorer health of White South Africans because of the higher MRs compared with those in England and Wales were cirrhosis of the liver in adults, gastro-enteritis, meningitis and septicaemia in infants and children, and 'other ill-defined and unknown causes of death' in elderly people.
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PMID:A comparison of the mortality rates of white South Africans with those of the population of England and Wales. 740 6

The mortality pattern of 15,318 Royal Naval submariners has been examined to asses the long term effects on health of serving in submarines. The main outcome measures used were standardised mortality ratios (SMRs) which present the submariners' mortality rates as a percentage of those for men in England and Wales. The SMR for all causes of death combined was low at 86, this being comparable to findings in other studies of Armed Forces personnel. Cancer mortality was particularly low with an SMR of 69 and there was no particular cancer site which showed an excess. Raised mortality from digestive diseases was seen: the excess was attributable to cirrhosis of the liver which gave rise to an SMR of 221 based on 12 deaths, alcohol being a contributory factor in eight. This excess mortality from cirrhosis was concentrated in the period 1970-79 and occurred in men who had left the Royal Navy. Deaths from accidents and violence were also higher than expected with an SMR of 115, but this was due to high levels of accidents occurring after discharge from the Navy.
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PMID:The mortality of Royal Naval submariners 1960-1989. 928 37


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