Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical and autopsy findings obtained from 15 male patients treated for acquired immunodeficiency syndrome (AIDS) at 3 hospitals in Sao Paulo provided a clearer profile of AIDS cases in Brazil. Of the 12 patients whose sexual orientation was recorded, 9 were homosexual and 3 were bisexual. 75% were between the ages of 22-36 years; 14 were white. The duration of diseases ranged from 14 days-7 months in this series, confirming the rapid evolution of AIDS from 1st symptom to death. The most common clinical manifestations of disease were fever, cough, weight loss, diarrhea, and lymphadenopathy. Organs most frequently involved were the lungs (13 cases) and encephalum (9 cases). Microscopic findings revealed 9 types of microorganisms, fungi, and protozoa, the most common of which was Cytomegalovirus (7 cases). The cause of death was meningoencephalitis in 7 cases and panlobar pneumonia in 3 cases. The incidence of Kaposi's sarcoma (2 cases) was surprisingly low in this series. In addition to lesions produced by microorganisms, there were important associated lesions represented by lymphocytic depletion, acute myocarditis, brown atrophy of neuronia, acute pancreatitis, and liver cirrhosis. Several microorganisms and tumors in these AIDS patients were discovered only at autopsy, confirming the importance of necropsy to the study of the natural history of this disease. An unexpected pathological finding in this series was the absence of cellular reactions to microorganisms, particularly Pneumocystis carinii, Cryptococcus neoformans, and Mycobacterium tuberculosis.
 ...
PMID:Acquired immune deficiency syndrome (AIDS) in Brazil. Necropsy findings. 362 18

Mortalities from selected causes from 1973 to 1982 among Koreans, Chinese, and Americans residing in Japan were compared with those of Japanese. In the Korean population, besides the well-documented excess in mortalities from liver cancer, lung cancer, liver cirrhosis and male tuberculosis, a rather prominent elevation was observed for mortalities from female tuberculosis and diabetes mellitus in both sexes. Distinctive features in the Chinese population were increased mortalities from liver cancer and female lung cancer and lowered mortality from stomach cancer, and these findings are consistent with the observations among Chinese in other areas. Mortalities from diabetes mellitus and liver cirrhosis was moderately increased in this population as well. Americans in Japan by and large showed a mortality pattern similar to that in the US although mortality from stroke among female Americans was rather elevated during the period 1973-1977. Epidemiological studies on Koreans and Chinese in Japan with reference to their lifestyle are strongly required.
 ...
PMID:Cause-specific mortality among Koreans, Chinese and Americans in Japan, 1973-1982. 366 40

One thousand seventy-two 24-hr diet duplicate samples were collected from inhabitants of 49 regions in various parts of Japan during the winters of 1977-1981. An additional 238 samples were collected in an adjacent summer. The samples were analyzed for sodium (Na) and potassium (K) by flame atomic absorption spectrometry and for chloride (Cl) with a chloride counter. The winter-summer differences in Na, Cl, and Na/K were essentially negligible. When the regional means of Na, K, Cl, and Na/K were compared with the 1969-1978 standardized mortality ratios of each region, positive and significant correlations were observed between winter Na and the standardized mortality ratios for cerebrovascular disease (P less than 0.01), cerebral infarction (P less than 0.01), and subarachnoid hemorrhage (P less than 0.05) in both males and females. The correlation (P less than 0.01) with the cerebrovascular disease standardized mortality ratio was further confirmed by the values for 1978-1982. In the case of the Na/K ratio, the correlation with the standardized mortality ratio for each of the three diseases was significant for men (P less than 0.01 or 0.05, depending on the disease) but not for women (P greater than 0.05). Both Na and Na/K showed significant associations with the ischemic heart disease standardized mortality ratio in men (P less than 0.05) but not in women (P greater than 0.05). In contrast, no positive association was found between Na, K, Cl, or Na/K and standardized mortality ratios for diabetes mellitus, liver cirrhosis, tuberculosis, or liver cancer (P greater than 0.05). Current blood pressure did not appear to correlate with any of the Na, K, Cl, or Na/K measurements. The validity of the present observation is discussed.
 ...
PMID:Correlation of cerebrovascular disease standardized mortality ratios with dietary sodium and the sodium/potassium ratio among the Japanese population. 371 59

The majority of staghorn calculi (branched calculi)--25 per cent bilateral--is mainly composed of calcium phosphates, in about 2/3 with varying fractions of Struvite. Pure Struvite stones are rare. Large fractions of Struvite form a soft concrement. Infection with urea splitting bacteria arises ascending, therefore predominantly in female kidneys, except for the first decennium. Staghorn calculi without Struvite (1/3 of our cases), show extremely large growth and sterile urine. Some Struvite stones have sterile urine or Struvite without urea splitting bacteria. The shape of branched calculi depends on the form of hilus renalis and the aggressiveness of the alkaline urine and the infection. Renal cirrhosis--almost always present--follows bacterial or abacterial obstruction, depending on the degree of vascular obliteration by reactive fibrosis of the intima, with or without pyonephrotic, xanthomatous necrosis, similar to renal tuberculosis. The so-called "large stone kidney" is obstructive, aseptic and lipomatous special form of staghorn calculus and cirrhosis. Stone formation and grade of cirrhosis may be determined by tomography.
 ...
PMID:[Classification of staghorn calculus disease of the kidney based on 105 personal cases and a review of the literature]. 371 38

The mortality pattern of Koreans living in Osaka, Japan was surveyed by comparing their age-specific and age-adjusted death rates with those among Japanese during 1973-1982. Cancer was the leading cause of death among Korean males, while cerebrovascular disease was most common among Korean females in Osaka. Mortality rates from tuberculosis, cancer, mental disorder, cerebrovascular disease, chronic obstructive pulmonary diseases (COPD), liver cirrhosis, accidents and suicide were significantly higher for Korean males than for Japanese males. COPD, liver cirrhosis and accidents were more frequent for Korean females than for Japanese females. In cancers, liver cancer was most common among Korean males, followed by stomach and lung cancers. Stomach cancer was most frequent among Korean females, followed by uterine and liver cancers. The ratio of cancer mortality rates for Koreans and Japanese was significantly higher than 1.0 for oesophagus, liver and lung among males, and for liver among females. Koreans had considerably higher levels of liver cancer and liver cirrhosis compared with Japanese. Mortality from stomach cancer was significantly lower in both sexes among Koreans in Osaka and the reduction of this disease among Koreans in Japan occurred more rapidly than among Japanese.
 ...
PMID:Mortality among Koreans living in Osaka, Japan, 1973-1982. 372 84

The University of California at Los Angeles School of Public Health, in collaboration with the Los Angeles County Department of Health Services, compiled data and developed a standardized format that displayed a comparison of mortality and morbidity data between Los Angeles County, the State of California, and the United States in 1960, 1970, and 1980 for 16 health topic areas. Findings noted both favorable and unfavorable health trends, as well as substantial data collection problems. In 1980, compared with the United States, the Los Angeles County rates for tuberculosis, gonorrhea, syphilis, and hepatitis B were as much as 45 to 128 percent higher, the homicide rate was more than double, and, for the population aged 65 years and over, the cirrhosis of the liver rate was more than 56 percent higher. The myocardial infarction rate was 58 percent lower in the population aged 18 to 64. Problems of inadequate data for many health indicators, lack of comparability in data, and conflicting information from different data sources were noted. These limitations with the data underscore the need to standardize data collection procedures and to extend the parameters on which information is collected. The approach represents a tool that could be used by many health departments to monitor their activities and set future goals.
 ...
PMID:Monitoring health in Los Angeles County. 392 83

Tuberculous ascites can be a difficult condition to diagnose. In the rural African population served by Jane Furse Hospital both tuberculosis and ascites are common conditions. Between 1 November 1982 and 31 October 1983, 80 patients were admitted with ascites. Open peritoneal biopsy was used in 18 patients in whom the cause was uncertain. In 5, biopsy showed caseating tuberculosis in the absence of any other evidence of active disease. In 6 the biopsy showed non specific changes which may be associated with tuberculosis or cirrhosis of the liver. No significant complications were encountered and it was concluded that this procedure was a useful, safe and rapid means of diagnosing tuberculous peritonitis.
 ...
PMID:The diagnosis of tuberculous ascites in a rural African community. 398 38

A case report is given of a man, who died at the age of 56. At post mortem examination the following was found: Postnecrotic cirrhosis of the liver, esophageal varicosis, ascites as well as multiple white nodes located in the serosal layer of the small intestine and the mesenterium. Histological examination showed fibromatosis. Differential diagnosis is discussed including other connective tissue tumors, Whipple's disease, peritoneal tuberculosis, Gardner syndrome, solitary fibromatosis, diffuse peritoneal fibromatosis and sclerosing peritonitis. Similarity of the findings reported with the disease entity of sclerosing mesenteritis is discussed as well as a possible causal relationship between liver cirrhosis and fibromatosis.
 ...
PMID:[Disseminated fibromatosis of the mesenterium]. 399 May 1

Electronmicroscopic and histochemical examination of connective tissue in the resected lungs of patients with fibrocavernous tuberculosis was carried out. High metabolic activity and developed ultrastructural organization of fibroblasts were observed in the foci of productive tissue response. The stages of cell differentiation and the maturation of collagen fibers resulted in the multilayer structure of both the tuberculosis foci and the cavernous wall. The activation of smooth muscle cells and myofibroblasts facilitated the development of perivascular and peribronchial sclerosis. Fibroblasts were found to be in connection with lymphoid cells and macrophages that influence the intensity of fibrosis. The formation of numerous lymphoid follicles combined with the progression of fibrosis is an unfavourable prognostic symptom as it results in an excessive cirrhosis and fibrosis which inhibits the healing of destructive tuberculosis.
 ...
PMID:[Connective tissue function and fibril formation processes in fibrous-cavernous pulmonary tuberculosis]. 400 87

Death certificates filed between 1960 and 1979 in Osaka, Japan were analyzed to study causes of death in diabetic patients. It was observed that diseases of the circulatory system increased continuously from 15.2% in 1960-1964 to 27.2% in 1975-1979. Cerebrovascular disease and disease of heart were the leading causes of death throughout the study period. The rate of increase was much faster for disease of heart than for cerebrovascular disease, and there was only a small difference between them as cause of death in diabetic patients at the end of the observation period. Malignant neoplasms, cirrhosis of the liver, and pneumonia and bronchitis increased, whereas tuberculosis decreased sharply according to age-adjusted mortality rate during the 20-year period. Analysis based on O/E ratios suggested higher risk of dying from ischemic heart disease, tuberculosis and cirrhosis of the liver in Japanese diabetics than in the general population in this country.
 ...
PMID:Causes of death in Japanese diabetics. A 20-year study of death certificates. 401 2


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>