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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 107 children with liver cirrhosis aged from 7 to 12 were kept under observation. Four types of diets with different variants of the fatty component were used in the course of their treatment. The diet No 5 ration contained a physiological set of basic nutrients (with vegetable oil comprising 12% of the total amount of fat in the ration). The diet 52 carried a higher amount of the vegetable oil with its proportion reaching 22% of the total quantity of fat at the expense of a lesser share of butter. The total amount of fat was consistent with the age-specific standard rate. The diets 53 and 54 has the amount of fat raised by 15% with respect to the physiological level through additional introduction of vegetable oil and butter "Zdorovie", respectively. The fat-enriched diets were well tolerated with no manifestations of steatorrhea in evidence. Against the background of all the diets applied the great majority of the patients demonstrated an improvement of both the clinical data (general conditions, reduction in the size of the liver) and a number of characteristics reflecting the functional capacity of the liver (normalization of the blood serum bilirubin, of proteinogram findings). Following the use of diets with an elevated fat content there could be observed a well-marked tendency toward normalization of metabolic rates. In particular the level of the blood serum cholesterol esthers was rising; the plasma and lipids of the erythrocytes stroma showed an increased proportion of arachidonic acid with simultaneous fall of the icosatrienic acid share. This may ascribed to a higher content of polyunsaturated fatty acids in the ration. The most convenient way of introducing polyunsaturated fatty acids in the ration is the dietetic butter "Zdorovie". This justifies recommending it in dietotherapy of children suffering from liver cirrhosis.
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PMID:[Comparative study of the therapeutic effect of diets with qualitatively and quantitatively different fat content on children with cirrhosis of the liver]. 88 13

An elderly man with long-standing pulmonary emphysema was seen with recent onset of steatorrhea and ascites. He had very low levels of serum alpha1-antitrypsin, hepatic cirrhosis, and intestinal mucosal atrophy. We believe this this combination of findings did not occur by chance.
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PMID:Alpha-1-antitrypsin deficiency, emphysema, cirrhosis, and intestinal mucosal atrophy. 107 83

Patients with active liver cirrhosis display greater abnormality in pancreatic function tests, viz. steatorrhea, hyperamylasemia, than patients with inactive cirrhosis. In autopsy specimens taken from patients dying from cirrhosis, parallel morphologic changes were noted in the liver and pancreas, viz. in postnecrotic cirrhosis, necrosis and necrobiosis predominated in the pancreas. In patients with portal cirrhosis, sclerotic changes rather than necrobiosis was observed in the pancreas. On the other hand, experimental acute and chronic pancreatitis induced in dogs displayed hepatic lesions whose degree and extent were correlated with the duration of the pancreatic inflammation.
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PMID:Hepatic lesions in pancreatitis. Clinicoexperimental data. 118 13

Mild to moderate fat malabsorption is frequently present in patients with liver cirrhosis. We investigated the influence of lactulose or lactitol treatment on fecal fat excretion in 18 patients with liver cirrhosis. All patients were Child Pugh class A or B and had not taken any therapy that could have affected intestinal absorption in the previous months. The dose of lactulose or lactitol was individually adjusted to maintain two semiliquid bowel movements per day. Steatorrhea was determined before and after a minimum of 7 days, when the cathartic effect was stabilized. Treatment with nonabsorbable disaccharides induced mild to moderate steatorrhea in 50% of patients. No differences were observed between the effects of lactulose and lactitol, but fecal fat excretion exceeded 10 g/day in two patients taking lactulose. These findings indicate that treatment with nonabsorbable disaccharides may increase fecal fat excretion in patients with liver cirrhosis. This factor should be taken into consideration when a cirrhotic patient has to take these drugs for a long time.
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PMID:The effect of lactulose and lactitol administration on fecal fat excretion in patients with liver cirrhosis. 140 23

Fifty nine C.F. pts (38 males) aged 14-41 years have been considered, for all of them the following parameters were taken into account: Shwachman clinical score modified (radiological evaluation emended), steatorrhea, liver function tests (SGOT, SGPT, GT, Bilirubin, AP, Quick T.), A and B hepatitis markers and ultrasonographic scan of pancreas and hepatobiliary system. 23 pts (38%) presented well recognized hepatobiliary involvement: 2 pts (3%) evident cirrhosis, 3 pts (5%) cirrhosis with portal hypertension and esophageal varices, 5 pts (8%) were affected with signs of chronic hepatopathy, 13 pts (22%) presented gallbladder stones.
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PMID:Hepatobiliary involvement in adolescents and adults with cystic fibrosis. 213 Jun 90

The aetiology and clinical characteristics of 42 patients affected with chronic calcifying pancreatitis in a Sicilian population were investigated and compared with a series of other Italian and foreign reports. It was found that the aetiology was 62% alcoholics and 38% idiopathic in origin and that the M/F ratio was 2.5:1. Clinical features as pain, weight loss, pancreatic calcifications, steatorrhea, pseudocysts and associated cirrhosis are significantly more frequent in the group of alcoholics, while cholelithiasis was more frequent in the non-alcoholic group. Two aspects are worth noting in comparison to the north of Italy: a) the lesser frequency of alcoholic forms and b) the high incidence of women.
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PMID:Chronic pancreatitis in Sicily. Preliminary reports. 213 26

In a double-blind, crossover study, 10 cirrhotic patients (Child B rating) with steatorrhoea (daily output of faecal fat greater than 8 g) and dyspepsia were placed on a controlled diet for 14 days. Patients then received 150 mg ursodeoxycholic acid (UDCA) or placebo twice daily for 14 days. Faecal fat excretion was reduced from 14.7 to 10.6 g/day by UDCA and dyspepsia symptom scores were also reduced. Serum aspartate aminotransferase concentrations declined significantly (P less than 0.02) following UDCA treatment, whereas serum bile acid levels increased from 35 to 40.5 microM and the percentage of UDCA increased to 22%. It is concluded that UDCA may be useful for many of the symptoms present in patients with liver cirrhosis.
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PMID:Steatorrhoea in cirrhosis: effect of ursodeoxycholic acid administration. 222 76

Anatomical abnormalities of the small bowel that cause intestinal stagnation result in bacterial overgrowth and a blind loop syndrome (BLS). Bacterial breakdown of bile salts and deamination of protein lead to malabsorption, steatorrhea, and fat-soluble vitamin deficiencies. Four children developed BLS as a complication of necrotizing enterocolitis, jejunal atresia, gastroschisis, and biliary atresia. BLS was suggested by abdominal pain, feculent vomiting, steatorrhea, and hypoalbuminemia. Dilated, stagnant bowel loops were demonstrated in each instance by upper gastrointestinal contrast study. Positive intestinal bacterial aspirates were confirmatory. Antibiotic treatment in two patients improved symptomatology but all children ultimately required surgery. Surgical procedures consisted of blind loop resection, intestinal plication, and catheterization of the bilioenteric conduit. All patients are now asymptomatic but one child suffers from parenteral nutrition-related cirrhosis and another requires chronic antibiotic therapy.
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PMID:The blind loop syndrome in children. 240 46

Intestinal permeability to 51Cr-EDTA was studied in 20 children with cystic fibrosis (CF) and a mean age of 10.7 years, in 7 control adults and in 11 control children. 51Cr-EDTA urinary excretion (mean +/- SD) expressed as a percentage of the orally administered activity was: control children: 1.59 +/- 0.55%, control adults: 1.47 +/- 0.62%, CF patients: 10.7 +/- 8.6%. The difference between CF patients and control children on one hand, between CF patients and control adults on the other hand, was statistically significant (p less than 0.001). Only 3 CF patients had values within the limits of those observed in controls. A statistically significant correlation (p less than 0.01) was observed between the 51Cr-EDTA urinary excretion and steatorrhea. No correlation was found between 51Cr-EDTA urinary excretion and the following parameters: age, sex, weight, height, Shwachman score, liver cirrhosis, oral administration of a mucolytic agent. The eventual, especially nutritional, consequences of this increase of the intestinal permeability in the course of CF remain to be clarified.
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PMID:[Abnormalities of intestinal permeability of 51Cr-EDTA in mucoviscidosis]. 250 45

The triolein breath test (TBT) is a simple, noninvasive technique for the evaluation of steatorrhea. However, because it depends on intermediary hepatic processes, and because both liver damage and pancreatic dysfunction often co-exist in the alcoholic, the overall usefulness of the test in patients with liver injury was reassessed. We found that even in the absence of steatorrhea, a majority of patients with advanced liver injury (alcoholic hepatitis, cirrhosis, or both) had abnormal TBT results that failed to correct with pancreatic extract. In contrast, patients with less severe lesions (steatosis) had results that were not significantly different from those in normal controls. Inasmuch as the abnormal TBT results in patients with advanced alcohol-induced lesions did not correct with pancreatic extract, the test may not accurately differentiate pancreatic from nonpancreatic steatorrhea in some alcoholics.
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PMID:Use of the triolein breath test in alcoholics with liver damage. 379 17


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