Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Result of hepatic resection in 150 patients with hepatocellular carcinoma (HCC) harboring up to three lesions smaller than 3cm in diameter (PEI candidates) and 144 patients with multiple lesions (TAE candidates) was studied. In PEI candidates, associated liver diseases were liver cirrhosis in 108 patients (72%) and chronic hepatitis in 41 (27.3%). Survival rates at 1-, 3- and 5-years were 98.0%, 83.5% and 61.4%, respectively. Prognosis of the patients with a well-differentiated solitary lesion was particularly good. In TAE candidates, 1-, 3- and 5-years survival rates were 98.5%, 57.8% and 33.7%, respectively. Half of the patients were considered to have multicentric disease, and their prognosis was better than that with intrahepatic metastases. Surgical resection is recommended as a primary treatment of HCC when the patients are feasible for surgery even if nonsurgical treatments are possible. Further study is required to establish the proper indication for nonsurgical procedures as a primary treatment of HCC in patients who are candidates of surgery.
 ...
PMID:[Result of surgical resection of hepatocellular carcinoma in possible candidates for nonsurgical treatments]. 133 12

Varices of the colostomy are a rare complication of colostomy performed in patients with portal hypertension. This work is based on 14 cases. The colic stomy is the terminal operation in surgery for cancer in twelve cases, and a bypass stomy in two cases. Portal hypertension is due to cirrhosis in 10 cases and to metastases to the liver in 4 cases. All 14 colostomy varices were expressed by bleeding. In 7 cases, oesophageal varices were detected with fiberendoscopy. Only one of these patients had an upper digestive hemorrhage. Colostomy hemorrhages are the revealing complication and the main sign of the disease. The emergent treatment of bleeding of the colostomy must combine several methods, most often consecutively: local compression, ligation, sclerotherapy. Once bleeding is controlled, the radical treatment must be primarily medical (hygienic and dietary habits, beta-adrenergic blocking agents), but complementary surgery may prove to be necessary, most often to redo the colostomy with additional deconnection. The prognosis mainly depends on the function of the liver, the deterioration of which is accelerated by the successive hemorrhagic accidents. Hepatorenal failure is the main cause of death.
 ...
PMID:[Colostomy-induced varices in portal hypertension]. 133 37

Repeated hepatic dearterialization combined with intra-arterial infusion chemotherapy was performed in 29 patients with unresectable primary or secondary cancer of the liver. Partial Response (PR) was obtained in 4 cases (1 hepatocellular carcinoma and 3 gastric secondaries), when evaluated by measuring the regression rate radiologically. The most remarkable effect was found in those with metastases from gastric cancer. A satisfactory result was not obtained for hepatocellular carcinoma with liver cirrhosis because of frequent associated complications. A strategy to modulate the resistance of tumors to ischemia and anticancer drugs should be considered in order to obtain a better clinical result by this method.
 ...
PMID:[Evaluation of repeated hepatic dearterialization combined with intra-arterial infusion chemotherapy of unresectable primary or secondary cancer of the liver]. 153 Mar 50

Incidence and morphologic pattern of liver metastasis from extrahepatic cancer in cirrhosis were studied in 2162 consecutive autopsies performed during a 12.5 year period. The cirrhotic liver was less frequently affected by metastasis than the noncirrhotic liver (33.3% versus 46.4%). The incidence of extrahepatic malignancies and their hematogenous metastasis was lower (though statistically not significant) in patients with cirrhosis than in patients without cirrhosis (20% versus 32%). Patients with cirrhosis but without cancer died at a younger age (63.5 years) than patients with both cancer and cirrhosis (69.5 years). In cirrhotic livers, metastases from neuroendocrine tumors were predominantly localized within the parenchymal nodules, while nonendocrine carcinomas metastasized to the fibrotic septa. The results suggest (1) that patients with cirrhosis develop less frequently extrahepatic malignancies and hepatic metastasis than patients without cirrhosis, probably because of a shorter life expectancy due to the complications of liver cirrhosis; (2) microscopic localization of metastases in cirrhotic livers depend on tumor type.
 ...
PMID:Incidence and morphology of liver metastasis from extrahepatic malignancies to cirrhotic livers. 161 Jul 70

Alcohol can induce a wide spectrum of histological changes in the liver. Three morphologic patterns of alcoholic liver injury are now generally accepted, i.e. fatty change, alcoholic hepatitis and alcoholic cirrhosis, but a broad array of lesions has been added to this list in recent years. These damage patterns differ considerably in their significance as to indication and diagnostic power of liver biopsies. Liver biopsy is recommended in patients with clinically suspected alcoholic liver disease for diagnostic and prognostic reasons. Moreover, clinicians want to exclude nonalcoholic liver diseases that might otherwise be missed. Alcoholic hepatitis, which is associated with increased morbidity and mortality, has the highest degree of diagnostic specificity in biopsies, because its features are well-defined and are mimicked by a rather small group of other causes. When associated with perivenular and pericellular fibrosis, it may provide prognostic parameters. In contrast, fatty liver, which may be induced by alcohol as well as other etiologies, usually does not need liver biopsy, with some exceptions. It may lead to cholestasis severe enough to mimic obstructive jaundice, or may result in abnormal imaging studies suggesting metastases. Verification of histological findings may be important when these circumstances arise. Cirrhosis is easily verified in biopsies of appropriate quality; however, advanced cirrhosis is a morphologically nonspecific alteration, because cirrhotic tissue patterns converge irrespective of their cause. Liver biopsy may help to identify nonalcoholic liver disease in patients suspected of harboring alcoholic liver disease. In fact, up to 20% of biopsies may show other, potentially treatable disorders, thus extending the indication for liver biopsy in situations of complex clinical and laboratory patterns.
 ...
PMID:[Liver biopsy in suspected alcoholic liver damage]. 162 Dec 36

Hepatic metastasis of colorectal cancer was found in 40 (16%) of 250 patients with colorectal cancer treated in our department during the past 5 years. Liver cirrhosis was not found among the 40 patients with metastases (16%) but was present in 46 (21.9%) of the 210 nonmetastatic patients, with a significant difference between the two groups (p less than 0.001). The rate of patients who were positive for hepatitis B surface antibody was 10% in the metastatic group and 34.3% in the nonmetastatic group, with a significant difference (p less than 0.01). These findings suggest that colorectal cancer does not metastasize to the injured liver, especially the cirrhotic liver.
 ...
PMID:Absence of colorectal cancer metastasis to the cirrhotic liver. 827 67

A semi-purified corn-based diet containing 50 mg/kg of pure (not less than 90%) fumonisin B1 (FB1), isolated from culture material of Fusarium moniliforme strain MRC 826, was fed to a group of 25 rats over a period of 26 months. A control group of 25 rats received the same diet without FB1. Five rats from each group were killed at 6, 12, 20 and 26 months. The liver was the main target organ in the FB1-treated rats and the hepatic pathological changes were identical to those previously reported in rats fed culture material of F.moniliforme MRC 826. All FB1-treated rats that died or were killed from 18 months onwards suffered from a micro- and macronodular cirrhosis and had large expansile nodules of cholangiofibrosis at the hilus of the liver. Ten out of 15 FB1-treated rats (66%) that were killed and/or died between 18 and 26 months developed primary hepatocellular carcinoma. Metastases to the heart, lungs or kidneys were present in four of the rats with hepatocellular carcinoma. No neoplastic changes were observed in any of the control rats. Chronic interstitial nephritis was present in the kidneys of FB1-treated rats killed after 26 months. No lesions were observed in the esophagus, heart or forestomach of FB1-treated rats and this is contrary to previous findings when culture material of the fungus was fed to rats. It is concluded that FB1 is responsible for the hepatocarcinogenic and the hepatotoxic but not all the other toxic effects of culture material of F.moniliforme MRC 826 in rats.
 ...
PMID:Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. 164 15

Ultrasound guided percutaneous alcoholization of the liver has been carried out using a large volume of alcohol (usually 20 to 30 ml) with no adverse reaction and its efficacy was perceptible after about 6 sessions. The best results were achieved in hepatocarcinomas in a context of Child A cirrhosis (6 out 6 lesion became negative). In hepatocarcinoma in a context of Child B and C cirrhosis and in hepatic metastases, the outcome depends on the initial disorder.
 ...
PMID:[Percutaneous alcohol injection of hepatic tumors using ultrasonic guidance: a new therapeutic approach]. 165 Jan 58

One hundred and six fine needle aspiration biopsies (FNAB) of the liver were performed on 99 patients to rule out hepatic malignancy. Biopsies were performed with CT guidance (60), ultrasonography (40), fluoroscopy (3), by direct palpation (2) and intra-operatively (1). The smears and cell blocks were reviewed and the cytologic diagnoses were made after clinicopathologic correlation. Eight cases were excluded (six non-diagnostic and two mislaid). Fifty-two were positive, 2 suspicious and 44 negative for malignancy. There were no false positive results. The sensitivity for malignancy was 84.4%, the specificity was 100% and the predictive value of positive results was 100%. The false negative rate was ten out of 44 cases (22.7%). Of the malignant aspirates, there were 27 hepatocellular carcinomas, 21 metastases and four carcinomas of unknown histogenesis. Common benign lesions included abscesses, cysts, cirrhosis and steatosis. For FNAB to be an effective diagnostic procedure, adequate representative sampling, cell block preparation for appraisal of histological architecture and experience in cytomorphologic interpretation are necessary to increase yield and enhance precision of diagnosis.
 ...
PMID:Cytological diagnosis from fine needle aspiration biopsy of the liver. 165 19

A retrospective analysis of 35 stage IV HCC (26 IV-A case and 9 IV-B cases) which underwent reduction surgery from 1983 suggested a possibility to extend their survival period by decrease in their tumor-mass and subsequent immunochemotherapy for improvement of their depressed immunity. Their operability depended on the clinical stage of accompanying liver cirrhosis and extent of distant organ metastasis. It is of first importance for reduction surgery to select intrahepatic multiple tumors, slow-growing and not rapidly to induce distant organ metastases, among them. Intrahepatic tumors arising from multicentric origins were found in 42% in IV-A cases but 0% in IV-B. DNA ploidy analysis of the multicentric tumors in 8 cases did not show any clear indication of resectable tumors according to DNA index. The present immunochemotherapy is composed of a continuous infusion of IL2 and intermittent one-shot injections of 10mg ADR to the remnant liver by using subcutaneously implanted pump. In patients who could enhance peripheral NK and LAK activities by the immunotherapy, decreases in intra- and extra- hepatic tumors were observed. The 2 year-survival rate was 49% in IV-A, but only one case who is receiving the immunotherapy is surviving over 2 years in IV-B.
 ...
PMID:[Significance of reduction surgery for stage IV hepatocellular carcinoma (HCC) and postoperative immunochemotherapy for extension of survival period]. 165 92


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>