Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

It was discovered that eight patients with complications of non-cirrhotic portal hypertension had received an arsenical preparation for psoriasis as Fowler's solution some years age. Seven of them were admitted for bleeding oesophageal varices. Upon admission, splenomegaly and hypersplenism were present. Liver tests were normal and palmar skin keratosis and melanosis were noted. Liver biopsy of six patients showed features of incomplete septal cirrhosis. Malignant skin lesions were present in half of the patients. One patient died from lung carcinoma and another from an ovarium neoplasm. Chronic arsenic intake should be actively looked for in all patients with psoriasis and non-cirrhotic portal hypertension. They should be followed up for many years for development of malignant lesions in skin, lung and liver. Liver abnormalities present in the biopsies are often minor and may escape detection.
 ...
PMID:Arsenic and non-cirrhotic portal hypertension. A report of eight cases. 180 30

Between 1972 and 1981 a total of 121 male and female wine-dressers with late after-effects from arsenic were medically examined and treated. Skin and liver were examined regularly every 3 months. With advancing years an increase in typically arsenic melanosis, precancerous, carcinomas and hyperkeratosis in palmae and plantae was observed. A significant increase in Dupuytren's contracture was found in the age groups between 50 and 80 with a growing progression of typically arsenic horned pearls on the palms of the hands and soles of the feet. The typically arsenic horned pearls and arsenical keratosis occurred most frequently in the Dupuytrenical changes of the skin. The liver parameters showed no pathological results such as cirrhosis of the liver as compared with the other patients.
 ...
PMID:[Dupuytren contracture in Mosel wine dressers with arsenic-induced aftereffect damage]. 621 79

From post-mortem examinations performed at the Pathology Institute at Koblenz, 163 cases of wine growers affected by chronic arsenic poisoning were analyzed. While a reduction could be seen in the number of cases of liver cirrhosis, the carcinoma rate was still high and even increased when compared to earlier reports. Lung cancers were identified in 66% of all wine growers affected and are thus the leading form of the skin were observed. A particular characteristic of amount of carcinomas or precarcinogenic alterations of arsenic carcinoma. However, nearly the same amount of carcinomas or precarcinogenic alterations of the skin were observed. A particular characteristic of cases. Among the multiple tumors, up to six different carcinomas were found. As arsenic is no longer detectable by toxicologic-chemical means the deposits of arsenic have been depleted and excreted long ago and so the diagnosis of chronic poisoning today depends on morphological changes of the skin (arsenic hyperkeratosis, melanosis and M. Bowen) which have been shown to be reliable. A comparison of our analysis with much more extensive material collected by the trade association supports our experience and the determined case rates. Furthermore modern theories on the carcinogenic action of arsenic, the question of the tumor latency and the relation of specific cancers to the poison are presented. In addition medical opinions on chronic arsenic poisoning are discussed.
 ...
PMID:The consequences of chronic arsenic poisoning among Moselle wine growers. Pathoanatomical investigations of post-mortem examinations performed between 1960 and 1977. 682 38

It is well recognized that liver cirrhosis may cause many characteristic skin changes. This paper deals with skin manifestations of liver cirrhosis, according to the pathological process. Portal hypertension may cause development of collateral circulation, including, visible varicose veins on the abdominal wall ("caput Medusae"). Hormonal disturbances, as the result of inability of the liver, are responsible for several vascular changes, such as, red palm, vascular spider and "paper money" skin, for gynecomastia and for loss of axillary and pubic hair. Nail changes, such as, clubbing, white nails, watch-glass deformity, flat nails and brittleness may be found in the patient with liver cirrhosis. Jaundice and melanosis are common. These skin changes are recognized as contributing to a diagnosis and estimating the stage of liver cirrhosis.
 ...
PMID:[Cutaneous manifestations of liver cirrhosis]. 811 88

Alcohol-induced diseases of the liver, such as fatty liver, hepatitis and cirrhosis with the potential development of hepato-cellular carcinoma can cause many effects on the skin. Even though they are not caused by excessive alcohol alone, but also by other diseases of the liver or other diseases of internal organs, an experienced person will be able to carry out specific diagnostic procedures. Skin symptoms due to liver diseases include 1. Vascular changes, such as spider nevi, teleangiectasias and palmar erythema. 2. Nail changes, particularly white nails. 3. Changes of the mucous membranes, i.e. glossy tongue. 4. Changes due to altered hormones, particularly gyneco-mastia, female distribution of hair and testicular atrophy and 5. Changes in the color of the skin like icterus and melanosis cutis. Rarely pruritus and other diseases of the skin are seen, such as porphyria cutanea tarda, which is often caused by an altered liver function. In the final stages of alcoholism, the neglect of personal hygiene particularly of the skin is evident (cutis vagantium). Since the exact mechanism of the skin symptoms remains obscure, it is difficult to evaluate the significance. Most often they do not correlate with the severity of the liver disease.
 ...
PMID:[Skin manifestations of alcoholic liver damage]. 1080 82