Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The liver is not only involved in metabolism and detoxification, but also participate in innate immune function and thus exposed to frequent target Thus, they are the frequent target of physical injury. Interestingly, liver has the unique ability to regenerate and completely recoup from most acute, non-iterative situation. However, multiple conditions, including viral hepatitis, non-alcoholic fatty liver disease, long term alcohol abuse and chronic use of medications can cause persistent injury in which regenerative capacity eventually becomes dysfunctional resulting in hepatic scaring and cirrhosis. Despite the recent therapeutic advances and significant development of modern medicine, hepatic diseases remain a health problem worldwide. Thus, the search for the new therapeutic agents to treat liver disease is still in demand. Many synthetic drugs have been demonstrated to be strong radical scavengers, but they are also carcinogenic and cause liver damage. Present day various hepatic problems are encountered with number of synthetic and plant based drugs. Nexavar (sorafenib) is a chemotherapeutic medication used to treat advanced renal cell carcinoma associated with several side effects. There are a few effective varieties of herbal preparation like Liv-52, silymarin and Stronger neomin phages (SNMC) against hepatic complications. Plants are the huge repository of bioactive secondary metabolites viz; phenol, flavonoid, alkaloid etc. In this review we will try to present exclusive study on phenolics with its mode of action mitigating liver associated complications. And also its future prospects as new drug lead.
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PMID:Role of Natural Phenolics in Hepatoprotection: A Mechanistic Review and Analysis of Regulatory Network of Associated Genes. 3117 20

A 45-year-old woman underwent uncomplicated orthotopic LT from a deceased donor for decompensated liver cirrhosis from hepatitis C [Model for End-stage Liver Disease (MELD) 16]. Although virologic clearance was achieved 18 months prior, the patient had three hospitalisations for West-Haven grade III HE that were precipitated by infection, despite long-term lactulose and rifaximin. The patient was listed for LT for the indication of recurrent HE and was prioritised due to the incidental finding of a 14mm right renal cell carcinoma (RCC). The RCC was unresectable due to portal hypertension and technically unsuitable for cryoablation, therefore partial nephrectomy was planned post-LT. Pre-LT abdominal computed tomography (CT) confirmed the presence of a large (25mm diameter) SPSS, however embolization on the waitlist was not warranted as the patient had no further hospitalisations for HE.
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PMID:Acute confusion post liver transplantation: HE or not HE, that is the question. 3262 41


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