Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The 24-hr diet duplicates were collected from 488 nonsmoking and nondrinking women at the ages of 30-59 years in 33 regions in Japan in winters, 1977-1981. The daily intake of Na, K, Cl and Na/K ratio for each individual were obtained by the chemical analysis of the duplicates, from which the regional means were calculated and subjected to regression analysis with 1969-1978 regional mortality for stomach cancer (SC), cerebrovascular disease (CVD) and liver cirrhosis for the middle-aged, 1969-1978 regional standardized mortality ratios (SMRs) for cancers of 9 sites and 9 other diseases (including SC and CVD), and 1978-1982 regional SMRs for SC, uterine cancer and CVD. No significant correlation was observed between intake of Na, K, Cl or Na/K and SC mortality or SMR, in contrast to a significant correlation of CVD mortality and SMR with Na intake (and to a lesser extent with K and Cl intake). Correlation of other cancers with Na was generally insignificant except for pancreatic cancer and possibly breast cancer. Thus, it was concluded that the correlation of daily Na intake with stomach cancer mortality is weaker, if present, than that with cerebrovascular disease mortality.
 ...
PMID:The absence of correlation between Na in diet duplicates and stomach cancer mortality in Japan. 317 23

The relation between alcohol consumption and several causes of death, including breast cancer, was examined in a population of 581, 321 women enrolled in a prospective study in 1959 and followed for 12 years. Women who drank occasionally had about the same breast cancer mortality rate as nondrinkers; those who drank one to four drinks per day had SMRs 7-26% higher; five drinks per day, 1.89; and six or more drinks per day, 1.65. The two highest-consumption groups' risks were significantly higher than those of nondrinkers after multivariate adjustment for several breast cancer risk factors. Distinctive dose-response relationships were observed for two known alcohol-related conditions: cirrhosis of the liver and cancer of the aero-digestive tract, suggesting that results for other causes are not seriously biased by misclassification of drinking habits. Death rates from all causes combined were elevated for drinkers of three or more drinks per day. Whether or not the association of elevated breast cancer death rates ultimately turns out to be causal, there is ample reason to continue to warn the public against excessive drinking.
 ...
PMID:Alcohol and breast cancer: a cohort study. 324 67

Serum levels of CA15-3, a mammary tumor associated antigen recognized by two different murine monoclonal antibodies (115D8 and DF3), were investigated in patients with mammary carcinoma and other benign or malignant diseases. The reference value of the serum CA15-3 level was obtained as 24 units/ml at the 99% confidence limit among healthy individuals (n = 462). Elevation of serum CA15-3 levels was observed in 24.3% of overall patients with mammary carcinoma. Serum CA15-3 levels in breast cancer patients correlated with the clinical stage; higher percentages of positivity were observed in those with advanced breast cancer (stage IV, 64.7%, recurrent, 52.4% and metastatic, 70.3%). Furthermore, elevated serum CA15-3 levels in breast cancer patients responded well to the effect of therapy. Although the serum CA15-3 test gave percentages of positivity of breast cancer similar to those found by the serum CEA test, the serum CA15-3 test revealed lower percentages of positivity than the serum CEA test among patients with benign breast lesions, liver cirrhosis or other carcinomas. These results suggest that the serum CA15-3 antigen level provides a very useful marker for diagnosis and clinical monitoring of patients with breast cancer.
 ...
PMID:Clinical evaluation of an immunoradiometric assay for CA15-3 antigen associated with human mammary carcinomas: comparison with carcinoembryonic antigen. 346 6

The alpha 1-antitrypsin (AAT) or protease inhibitor (Pi) genetic polymorphism was studied in 144 white, 100 coloured, 104 Indian and 127 black (Northern Sotho) healthy individuals (controls), in the Pretoria area. Their Pi phenotype and gene frequency distributions are compared with world-wide data on other population groups. The severely deficient Pi phenotypes S, Z and SZ jointly attain frequencies of 0.3-0.4% in coloureds and whites; in blacks and Indians the corresponding frequencies are very much lower. The implication for preventive medicine and public health is that in South Africa the sequelae of Pi deficiencies such as cirrhosis of the liver and/or emphysema of the lung are of practical importance in whites and coloureds and much less so in blacks and Indians. In 176 white breast cancer patients studied, the Pi phenotype and gene frequency distributions were found to be similar to those of healthy controls (not statistically significant). Cohorts of other patients were also phenotyped because of their low alpha 1-globulin concentrations in routine serum protein electrophoresis and/or their specific disease condition (cirrhosis of the liver or emphysema of the lung) known to be associated with AAT deficiency. These results are discussed in terms of their significance for family follow-up, genetic counselling and a preventive service. The need to avoid atmospheric pollution, especially cigarette smoke, is emphasised as a major and cost-effective preventive measure.
 ...
PMID:Alpha-1-antitrypsin genetic polymorphism in South Africa. 349 69

A histological examination of 306 breast tissues taken consecutively from autopsied Japanese women aged from 12 to 104 during the period between 1973 and 1984, excluding breast cancer cases, was undertaken. Two peaks at the ages of 40 to 44 and 55 to 59 were seen in the age-frequency distribution of fibrocystic disease (FCD), blunt duct adenosis (BDA), and duct papillomatosis (DP). There was no significant difference in the frequency of FCD, BDA, and apocrine metaplasia between the cases of liver cirrhosis and those without any hepatic disorders (controls). On the other hand, DP was seen more frequently and in higher degree in those with liver cirrhosis as compared with controls.
 ...
PMID:[Fibrocystic disease of the breast in autopsy cases with special reference to the age frequency distribution of epithelial hyperplasia and its relation to liver cirrhosis]. 378 77

Although systemic infections with Pasteurella multocida rarely occur in humans, liver cirrhosis associated with septicemia due to this organism has been frequently reported. Two cases of elderly women with Pasteurella multocida septicemia are described who had diabetes mellitus and breast cancer, respectively. Underlying diseases other than liver cirrhosis as well as factors hitherto unknown in otherwise healthy persons also enhance the risk of Pasteurella multocida septicemia.
 ...
PMID:Pasteurella multocida septicemia not associated with primary liver disease. 646 69

The cancer hazard rate (or force of mortality) of all cancer survival curves of the 4th Report on End Results in Cancer, continuously declines. This pattern recurs also in breast cancer patients refusing treatment. The declining hazard rate is most conspicuous in Cancer and much less pronounced in other chronic diseases. In most of them the hazard rate actually increases. Such is obvious in any actuarial life table, in which the rising pattern represents aging and will therefore be denominated herewith as Aging pattern. It accompanies also many chronic diseases e.g. diabetes, following operation for peptic ulcer, young survivors from coronary occlusion, or cirrhosis. The cancer hazard rate exhibits a trend observable during regeneration and is viewed here to reflect a regenerative process operating in cancer which is ascribed to Neoplasia.
 ...
PMID:On the improving chances of the cancer patient. 666 94

The distribution of detectable antibodies against antigen Dd has been studied in rheumatoid arthritis, goitre, nephrotic syndrome, cirrhosis, gastrointestinal tract diseases, neurological diseases, liver and gall bladder diseases, breast cancer, respiratory diseases and cardiovascular diseases. Except in rheumatoid arthritis, breast cancer and nephrotic syndrome, where the incidence of antigen Dd-reactivity did not differ much from that in the control group, in all other disease it was significantly lower.
 ...
PMID:Antigen Dd reactivity in selected diseases. 668 Jun 63

beta-Galactosidase and associated activities (beta-glucosidase and beta-fucosidase) have been studied in rabbit and bovine liver and rabbit spleen. The physico-chemical (optimal pH, pI, MW) and kinetical (Km, Vmax, Ki) properties were determined for all the activities. Two enzyme forms were separated in rabbit spleen. beta-Galactosidase, beta-fucosidase and beta-glucosidase activities were catalyzed by the same enzyme in rabbit and bovine liver. The enzyme from bovine liver showed nonlinear double-reciprocal plots, suggesting a substrate-activation model, and the presence of more than one binding site in the enzyme. The enzyme activities of several glycosidases were determined in human sera fom control groups and from patients with diabetes mellitus, pancreatitis, hepatitis, cirrhosis, stomach and breast cancer, myocardial infarction and renal failure. The results show significantly different enzyme levels for several glycosidases in all the studied diseases. Experimentally-induced diabetes mellitus, alcoholism and nephrotoxicity in rats showed different glycosidase levels in several tissues, as compared with control groups.
 ...
PMID:[Glycosidases of mammals: association of activities and changes of levels in some disorders]. 681 36

Amont 338 women treated in Massachusetts with isoniazid (isonicotinic acid hydrazide = INH) for pulmonary tuberculosis, no excess cancer deaths occurred (8 observed vs 8.3 expected) after 23 years (12.9 mean) of follow-up. There was an excess of cancer deaths (54 vs 35.7) among 1,090 patients who did not receive INH, partly due to radiogenic breast cancer resulting from multiple chest fluoroscopies to monitor pneumothorax. Increased deaths from liver cirrhosis (5 vs 0.8) were observed following INH use, suggesting that chronic as well as acute liver disease complicate this treatment.
 ...
PMID:Late effects following isoniazid therapy. 740


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>