Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023890 (cirrhosis)
 42,195 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum guanase activity was measured using a sensitive colorimetric method in patients with liver diseases. Guanase activity was correlated with GPT, GOT in acute viral hepatitis and chronic hepatitis, however, in liver cirrhosis and hepatocellular carcinoma it was correlated with total bilirubin as well as aminotransferases. In addition, the GPT-to-guanase ratio differed chronic hepatitis from liver cirrhosis. These findings suggest that determination of guanase and aminotransferases in useful in differentiation of liver diseases as well as assessing liver damage.
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PMID:Clinical significance of serum guanase activity in various liver diseases. 254 77

Serum guanase activity was measured in 20 healthy adults and in 62 patients with acute viral hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis and fatty liver. Guanase and gamma-GT in patients were elevated in 87 and 64%, respectively. Elevated guanase activities were found in most cases of acute viral hepatitis, as well as in chronic hepatopathies. In patients with acute viral hepatitis pathologic activities of guanase were found following partial or total normalization of other liver function tests.
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PMID:Evaluation of serum guanase in hepatic diseases. 610 73