Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023890 (
cirrhosis
)
42,195
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Infections are an important cause of morbidity and mortality in patients with decompensated
cirrhosis
and ascites. Hypothesizing that innate immune dysfunction contributes to susceptibility to infection, we assessed ascitic fluid macrophage phenotype and function. The expression of
complement receptor of the immunoglobulin superfamily
(
CRIg
) and CCR2 defined two phenotypically and functionally distinct peritoneal macrophage subpopulations. The proportion of
CRIg
hi
macrophages differed between patients and in the same patient over time, and a high proportion of
CRIg
hi
macrophages was associated with reduced disease severity (model for end-stage liver disease) score. As compared with
CRIg
lo
macrophages,
CRIg
hi
macrophages were highly phagocytic and displayed enhanced antimicrobial effector activity. Transcriptional profiling by RNA sequencing and comparison with human macrophage and murine peritoneal macrophage expression signatures highlighted similarities among
CRIg
hi
cells, human macrophages, and mouse F4/80
hi
resident peritoneal macrophages and among
CRIg
lo
macrophages, human monocytes, and mouse F4/80
lo
monocyte-derived peritoneal macrophages. These data suggest that
CRIg
hi
and
CRIg
lo
macrophages may represent a tissue-resident population and a monocyte-derived population, respectively. In conclusion, ascites fluid macrophage subset distribution and phagocytic capacity is highly variable among patients with chronic liver disease. Regulating the numbers and/or functions of these macrophage populations could provide therapeutic opportunities in cirrhotic patients.
...
PMID:CRIg-expressing peritoneal macrophages are associated with disease severity in patients with cirrhosis and ascites. 2769 69
