Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
tyrosine kinase
3291
CML
3246
BCR
2720
ABL
2629
Sep
1219
lymphoid
946
bcr
941
HLA
799
BCR-ABL1
786
interferon
747
AML
699
BCR/ABL
657
Mol
646
ALL
632
CD34
537
IFN
480
erythroid
429
breakpoint cluster region
373
interferon-alpha
354
bcr/abl
326
granulocyte
305
p210
299
p53
287
cytokine
281
BCR-ABL fusion
261
ABL1
255
Tyrosine kinase
235
caspase-3
225
non-Hodgkin's lymphoma
221
c-abl
210
ATP
198
JAK2
198
hemoglobin
188
She
185
c-kit
178
Bcl-2
177
BCR/ABL fusion
172
CLL
171
FISH
170
interferon alpha
169
more...
Disease
chronic myeloid leukemia
18916
leukemia
4580
cancer
4503
acute myeloid leukemia
2674
ABL
2629
blast crisis
2195
acute lymphoblastic leukemia
2017
tumor
1663
lymphoma
1227
myelodysplastic syndrome
948
Leukemia
896
graft-versus-host disease
886
myeloproliferative disorders
874
acute leukemia
759
chronic lymphocytic leukemia
674
multiple myeloma
563
chronic lymphocytic leukemia
542
hematologic malignancies
452
polycythemia vera
417
Hodgkin's disease
372
essential thrombocythemia
359
minimal residual disease
354
myeloid leukemia
334
chronic phase CML
327
myelofibrosis
301
non-Hodgkin's lymphoma
294
thrombocytosis
287
lymphoblastic leukemia
282
leukemogenesis
276
primary myelofibrosis
269
acute promyelocytic leukemia
261
thrombocytopenia
256
anemia
241
aplastic anemia
232
diabetes
187
residual disease
186
breast cancer
169
acute nonlymphocytic leukemia
165
stromal tumors
164
carcinoma
160
more...
Symptom
splenomegaly
247
diarrhea
114
fatigue
83
nausea
78
pain
71
vomiting
60
hepatosplenomegaly
58
headache
55
dyspnea
53
nausea and vomiting
50
weakness
36
abdominal pain
34
hepatomegaly
30
anorexia
30
muscle cramps
25
cough
23
bone pain
22
erythema
20
myalgia
20
Ill
19
arthralgia
14
seizures
14
respiratory distress
11
chest pain
11
HSA
11
exhaustion
10
asthenia
10
discomfort
10
shortness of breath
10
paresthesia
10
constipation
10
back pain
10
discomfort
10
collapse
9
chills
9
starvation
9
cachexia
7
periorbital edema
7
abdominal discomfort
7
chromosome marker
7
more...
Drug
Imatinib
1143
Gleevec
690
lysine
368
Dasatinib
276
CSF
170
MDS
157
G-CSF
144
Dermatol
86
IFN-gamma
76
IL-2
69
Bosutinib
61
Leaf
51
ROS
48
TEL
35
CTX
30
Arsenic trioxide
25
Campath
22
Campath
22
ADM
20
KCL
19
Cardiovasc
19
Herceptin
17
ABC
17
Adriamycin
16
G418
16
TRM
16
Monit
16
ADR
15
Gel
14
anti-CD33
13
Bortezomib
12
Hypaque
12
Hypaque
12
vitamin E
12
ascorbate
12
MAP
11
VCR
11
CTX
11
Vindesine
11
Vindesine
11
more...
Enzyme
focal adhesion kinase
3051
ERK
526
mitogen-activated protein kinase
293
BMT
278
reverse transcriptase
198
caspase-3
190
protein kinase
181
peroxidase
164
alkaline phosphatase
141
P-glycoprotein
116
PARP
89
MEK
83
CD13
75
CD10
70
proteasome
68
RNA polymerase
67
TdT
55
transcriptase
51
caspase-9
47
luciferase
44
protein kinase C
43
lactate dehydrogenase
40
phosphatidylinositol 3-kinase
36
lysozyme
34
RNase
31
trypsin
30
superoxide dismutase
30
glucose-6-phosphate dehydrogenase
29
catalase
29
caspase-8
28
RNase
28
calcineurin
28
topoisomerase
28
cdc2
27
alanine aminotransferase
26
acid phosphatase
26
ATPase
25
CYP3A4
24
topoisomerase
24
phosphoinositide 3-kinase
23
more...
Compound
BCR
2720
ABL
2629
DNA
1442
Dec
1313
Clin
1100
tyrosine
648
lysine
379
oxygen
234
ATP
198
glucose
177
MTT
152
retinoic acid
128
water
116
calcium
113
Ara-C
107
sodium
98
acetate
95
Ara-C
92
phosphate
90
serine
86
His
86
Busulfan
76
iron
73
arginine
72
TBI
72
threonine
72
Tyrosine
70
Hydroxyurea
62
MEK
59
cysteine
57
leucine
56
iodine
54
methionine
50
TNF
49
GTP
48
pentosidine
48
Methotrexate
46
SDS
44
pyrimidine
44
Phe
43
more...