Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
tyrosine kinase 3291
CML 3246
BCR 2720
ABL 2629
Sep 1219
lymphoid 946
bcr 941
HLA 799
BCR-ABL1 786
interferon 747
AML 699
BCR/ABL 657
Mol 646
ALL 632
CD34 537
IFN 480
erythroid 429
breakpoint cluster region 373
interferon-alpha 354
bcr/abl 326
granulocyte 305
p210 299
p53 287
cytokine 281
BCR-ABL fusion 261
ABL1 255
Tyrosine kinase 235
caspase-3 225
non-Hodgkin's lymphoma 221
c-abl 210
ATP 198
JAK2 198
hemoglobin 188
She 185
c-kit 178
Bcl-2 177
BCR/ABL fusion 172
CLL 171
FISH 170
interferon alpha 169
MDS 157
STAT5 156
CD8 149
G-CSF 144
granulocyte-macrophage 143
alkaline phosphatase 140
granulocyte colony-stimulating factor 137
KIT 136
fused 135
collagen 131
AKT 129
p190 129
CD4 125
IL-3 123
HLA-DR 121
MAPK 117
proto-oncogene 113
P-glycoprotein 113
megakaryocyte 113
protein tyrosine kinase 111
p21 110
mTOR 109
PI3K 108
P210 104
tumor necrosis factor 104
CD33 99
FAB 99
ERK 98
GM-CSF 98
CD38 95
erythropoietin 94
myeloperoxidase 92
human leukocyte antigen 92
platelet-derived growth factor receptor 90
granulocyte-macrophage colony-stimulating factor 89
CSF 89
glycoprotein 86
STAT 85
PHA 84
HLA-A 84
catenin 83
peroxidase 82
SRC 82
stem cell factor 81
PARP 80
cryptic 79
p38 78
FLT3 77
all-trans 77
IFN-gamma 77
SCT 75
CD13 75
cytochrome c 75
CEL 75
BCR-ABL fusion protein 74
receptor tyrosine kinase 74
serum albumin 74
interleukin-2 73
NMR 73
p13 71
fibronectin 71
c-myc 71
Mcl-1 70
annexin V 70
promyelocytic leukemia 69
proteasome 68
histone deacetylase 68
NHL 67
chimeric protein 67
Pol 66
IL-6 65
TdT 65
WT1 65
c-Myc 65
histone 64
IL-2 64
phosphatase 63
MLC 62
MHC 62
vascular endothelial growth factor 61
MEK 60
TEL 60
caspase-9 60
ras 59
thymus 59
ABCB1 59
CD10 59
esterase 58
MDR1 57
p15 57
PML 55
Fas 55
p27 55
AML1 55
NOD 55
STAT3 54
MMR 54
threonine 54
T cell receptor 54
mast cell 54
CD56 54
CD19 54
CD117 53
ara 52
telomeric 52
ERK1 52
CD7 51
ABCG2 50
PDGFR 50
platelet-derived growth factor 49
survivin 49
TNF 49
IgG3 48
insulin 48
albumin 48
ROS 48
JNK 48
c-ABL 47
p11 47
EVI1 47
more...
Disease
chronic myeloid leukemia 18916
leukemia 4580
cancer 4503
acute myeloid leukemia 2674
ABL 2629
blast crisis 2195
acute lymphoblastic leukemia 2017
tumor 1663
lymphoma 1227
myelodysplastic syndrome 948
Leukemia 896
graft-versus-host disease 886
myeloproliferative disorders 874
acute leukemia 759
chronic lymphocytic leukemia 674
multiple myeloma 563
chronic lymphocytic leukemia 542
hematologic malignancies 452
polycythemia vera 417
Hodgkin's disease 372
essential thrombocythemia 359
minimal residual disease 354
myeloid leukemia 334
chronic phase CML 327
myelofibrosis 301
non-Hodgkin's lymphoma 294
thrombocytosis 287
lymphoblastic leukemia 282
leukemogenesis 276
primary myelofibrosis 269
acute promyelocytic leukemia 261
thrombocytopenia 256
anemia 241
aplastic anemia 232
diabetes 187
residual disease 186
breast cancer 169
acute nonlymphocytic leukemia 165
stromal tumors 164
carcinoma 160
melanoma 160
MDS 157
Philadelphia chromosome positive 154
chronic myeloproliferative disorders 152
chronic myelomonocytic leukemia 142
myelosuppression 140
neutropenia 137
sarcoma 135
tumorigenesis 132
cytomegalovirus 122
hairy cell leukemia 117
interstitial pneumonia 105
trisomy 8 102
tumor progression 102
pneumonia 100
sepsis 98
tumor growth 96
T-cell acute lymphoblastic leukemia 94
eosinophilia 93
WT1 91
B-ALL 89
lung cancer 87
PHA 84
Burkitt's lymphoma 81
chronic leukemia 80
SCID 80
chloroma 80
CML progression 78
rash 78
pancytopenia 78
SCT 75
Epstein 75
lymphadenopathy 74
hypertension 74
sepsis 74
adenocarcinoma 71
gastrointestinal stromal tumor 70
B-cell lymphoma 69
erythroleukemia 68
NHL 67
carcinogenesis 67
Acute graft-versus-host disease 66
dysplasia 64
MLC 62
solid tumor 62
hepatocellular carcinoma 60
prostate cancer 59
mastocytosis 59
trisomy 59
lymphoproliferative disorders 59
immunodeficiency 58
PML 57
NOD 56
renal cell carcinoma 55
refractory anemia 53
veno-occlusive disease 52
leukopenia 51
metastases 49
heart failure 49
atherosclerosis 47
chronic neutrophilic leukemia 47
Best 47
colorectal cancer 47
neuroblastoma 46
relapsed CML 46
acute monocytic leukemia 44
non-small cell lung cancer 43
HIV 43
thalassemia 43
colon cancer 43
SDS 43
hepatitis 42
renal failure 41
lymphocytosis 40
Chronic GVHD 40
juvenile myelomonocytic leukemia 39
rheumatoid arthritis 39
retinoblastoma 38
adult ALL 38
sickle cell disease 38
hyperglycemia 38
squamous cell carcinoma 37
lung carcinoma 37
glioblastoma 36
respiratory failure 36
gastric cancer 35
atypical chronic myeloid leukemia 35
tuberculosis 35
GSH 35
MCF 35
chronic eosinophilic leukemia 35
follicular lymphoma 34
acute undifferentiated leukemia 34
erythrocytosis 34
monocytic leukemia 33
chronic disease 33
childhood ALL 33
neoplastic transformation 33
depression 33
pancreatic cancer 31
Alzheimer's disease 31
histiocytic lymphoma 31
CP1 31
vasculitis 30
hepatitis B 30
stomatitis 30
cold 29
type 2 diabetes 29
disseminated intravascular coagulation 29
Down syndrome 29
refractory CML 29
B-cell chronic lymphocytic leukemia 28
priapism 28
chloroma 27
APL 27
Ewing's sarcoma 27
RAEB 27
agranulocytosis 27
secondary AML 27
rare disease 27
more...
Symptom
splenomegaly 247
diarrhea 114
fatigue 83
nausea 78
pain 71
vomiting 60
hepatosplenomegaly 58
headache 55
dyspnea 53
nausea and vomiting 50
weakness 36
abdominal pain 34
anorexia 30
hepatomegaly 30
muscle cramps 25
cough 23
bone pain 22
erythema 20
myalgia 20
Ill 19
seizures 14
arthralgia 14
chest pain 11
HSA 11
respiratory distress 11
back pain 10
discomfort 10
constipation 10
shortness of breath 10
paresthesia 10
exhaustion 10
asthenia 10
discomfort 10
chills 9
collapse 9
starvation 9
cachexia 7
periorbital edema 7
chromosome marker 7
lethargy 7
anesthesia 7
abdominal discomfort 7
abdominal fullness 6
vertigo 6
intestinal bleeding 6
dizziness 6
dry skin 5
non-productive cough 5
acute abdomen 5
hip pain 5
syncope 4
rigors 4
sleepiness 4
tinnitus 4
exertional dyspnea 4
night sweats 4
acidity 4
insomnia 4
hypoproteinemia 3
tremor 3
pallor 3
overweight 3
paresis 3
dysuria 3
forgetfulness 3
blurred vision 3
ataxia 3
rales 3
thinning 3
hemoptysis 3
numbness 3
oliguria 2
skin irritation 2
agitation 2
epigastric pain 2
ophthalmoplegia 2
Gastrointestinal symptoms 2
spasm 2
chronic cough 2
dysesthesia 2
cyanosis 2
regurgitation 2
dysarthria 2
otalgia 2
Fluctuation 2
Roth spots 2
productive cough 2
decreased appetite 2
tachypnea 2
polyuria 2
flushing 2
colic 2
low back pain 2
consciousness disturbance 2
hoarseness 1
lightheadedness 1
leg edema 1
sciatica 1
skin damage 1
functional recovery 1
hypothermia 1
neck pain 1
syncopal episodes 1
polydipsia 1
shoulder pain 1
orthopnea 1
leg pain 1
muscle stiffness 1
Pain and tenderness 1
Welt 1
giddiness 1
tenesmus 1
persistent cough 1
giddiness 1
No adverse effect 1
adenitis 1
nipple pain 1
tense 1
nipple pain 1
swollen leg 1
general problem 1
pubic pain 1
acute pain 1
personality change 1
myoclonus 1
neuralgia 1
abnormal breathing 1
No respiratory symptoms 1
despair 1
thigh pain 1
localized edema 1
emaciation 1
tonic-clonic seizure 1
torticollis 1
right upper quadrant pain 1
Mental status changes 1
facial droop 1
Flu-like symptoms 1
fever of unknown origin 1
analgesia 1
heartburn 1
generalized rash 1
acute abdominal pain 1
prostration 1
hemiplegia 1
spasticity 1
arm weakness 1
chest tightness 1
Lhermitte's sign 1
Severe pain 1
atypical chest pain 1
Drug
Imatinib 1143
Gleevec 690
lysine 368
Dasatinib 276
CSF 170
MDS 157
G-CSF 144
Dermatol 86
IFN-gamma 76
IL-2 69
Bosutinib 61
Leaf 51
ROS 48
TEL 35
CTX 30
Arsenic trioxide 25
Campath 22
Campath 22
ADM 20
KCL 19
Cardiovasc 19
Herceptin 17
ABC 17
G418 16
Adriamycin 16
Monit 16
TRM 16
ADR 15
Gel 14
anti-CD33 13
Hypaque 12
ascorbate 12
Bortezomib 12
Hypaque 12
vitamin E 12
Vindesine 11
MAP 11
CTX 11
VCR 11
CTX 11
Vindesine 11
MRC 10
Rituximab 10
Gefitinib 10
Etoposide 10
-deoxyadenosine 10
Fludarabine 10
ARA-C 9
Intron A 9
AraC 9
Intron A 9
Heme 8
Anagrelide 8
THF 8
VCR 8
Asn 8
Intron A 8
ROC 8
Dial 8
Sorafenib 7
Prednisolone 7
PTH 6
IFN-beta 6
Idarubicin 6
Adenosine deaminase 6
Orphan 6
Ranitidine 5
Asthma 5
AZT 5
AZT 5
NBT 5
Dacogen 5
NVP 5
TTC 5
ENT 5
ampicillin 4
LCM 4
Bevacizumab 4
Tipifarnib 4
GEO 4
Vitamin B 4
Azacytidine 4
Troxacitabine 4
lactose 4
Fragment 4
ACT 4
Cetuximab 4
Tacrolimus 4
Bestatin 4
LCM 4
DNase I 4
Genasense 4
IL-11 4
Albumin 4
ZnO 4
Histamine 4
Mutagen 4
EE2 4
caffeine 4
citric acid 4
ETS 4
CAM 3
Interferon alfa-2a 3
Docetaxel 3
Vinorelbine 3
Roferon A 3
DDAVP 3
Furan 3
Novantrone 3
Simvastatin 3
Norplant 3
Emodin 3
CTC 3
Nexavar 3
Flavopiridol 3
Filgrastim 3
IL-1ra 3
Lovastatin 3
AIC 3
p75 3
NADH 3
DDAVP 3
TAK 3
Erlotinib 3
Honey 3
PTC 3
Sunitinib malate 3
ETA 3
Antithymocyte globulin 3
Ganciclovir 3
Taxol 3
Emodin 3
Radicicol 3
Clofarabine 3
Tarceva 3
PFA 3
TAT 3
niacin 2
Photofrin II 2
Vitamin E 2
Tocopherol 2
Indomethacin 2
Amifostine 2
Lenograstim 2
Glutathione 2
Xylocaine 2
ZnCl2 2
ZnCl2 2
EPA 2
Auranofin 2
TAC 2
Prednisone 2
PE2 2
Fluconazole 2
Hoelen 2
Portal 2
CPT-11 2
Dakar 2
Activin 2
Gastro 2
more...
Enzyme
focal adhesion kinase 3051
ERK 526
mitogen-activated protein kinase 293
BMT 278
reverse transcriptase 198
caspase-3 190
protein kinase 181
peroxidase 164
alkaline phosphatase 141
P-glycoprotein 116
PARP 89
MEK 83
CD13 75
CD10 70
proteasome 68
RNA polymerase 67
TdT 55
transcriptase 51
caspase-9 47
luciferase 44
protein kinase C 43
lactate dehydrogenase 40
phosphatidylinositol 3-kinase 36
lysozyme 34
RNase 31
trypsin 30
superoxide dismutase 30
catalase 29
glucose-6-phosphate dehydrogenase 29
RNase 28
caspase-8 28
topoisomerase 28
calcineurin 28
cdc2 27
acid phosphatase 26
alanine aminotransferase 26
ATPase 25
CYP3A4 24
topoisomerase 24
glutathione S-transferase 23
phosphoinositide 3-kinase 23
asparaginase 23
DNA polymerase 23
thrombin 22
neuraminidase 21
caspase-1 20
adenosine deaminase 20
adenosine deaminase 19
AMPK 19
AMP-activated protein kinase 19
aspartate aminotransferase 19
farnesyltransferase 18
IMP dehydrogenase 18
farnesyltransferase 18
glyceraldehyde-3-phosphate dehydrogenase 17
MDR 16
elastase 16
MIP 14
AMPK 14
ACS 13
endonuclease 13
DNA methyltransferase 13
neutrophil elastase 12
NADPH oxidase 12
STR 12
NADPH oxidase 12
tryptase 11
IKK 11
GSK 11
plasmin 10
carboxylesterase 10
hypoxanthine-guanine phosphoribosyltransferase 10
urokinase-type plasminogen activator 9
glyceraldehyde-3-phosphate dehydrogenase 9
glyceraldehyde-3-phosphate dehydrogenase 9
ribonucleotide reductase 9
glyceraldehyde-3-phosphate dehydrogenase 9
dihydrofolate reductase 9
gamma-glutamyl transpeptidase 9
MAP 9
protein phosphatase 2A 9
glyceraldehyde-3-phosphate dehydrogenase 9
APC 8
thymidine kinase 8
sialyltransferase 8
sialyltransferase 8
sialyltransferase 8
creatine kinase 8
beta-galactosidase 8
aldehyde dehydrogenase 8
cathepsin G 8
beta-glucuronidase 8
ribonucleotide reductase 8
phospholipase C 8
collagenase 7
12-lipoxygenase 7
lipase 7
ribonuclease 7
granzyme B 7
pyruvate kinase 7
ribonuclease 7
thioredoxin reductase 7
thromboplastin 7
hexokinase 6
NQO1 6
proteinase-3 6
ricin 6
cystathionine beta-synthase 6
papain 6
glutathione peroxidase 6
UDP-glucuronosyltransferase 6
purine nucleoside phosphorylase 6
lipoxygenase 6
DAT 6
pepsin 5
renin 5
methylenetetrahydrofolate reductase 5
NOS 5
sialidase 5
thymidylate synthase 5
caspase-2 5
alpha-mannosidase 5
S1 nuclease 5
phosphodiesterase 5
caspase-2 5
15-lipoxygenase 5
methylenetetrahydrofolate reductase 5
ornithine decarboxylase 5
CaMKII 5
cathepsin D 5
demethylase 5
sulfatase 5
tissue plasminogen activator 4
homocysteine methyltransferase 4
DNase 4
caspase-7 4
MCS 4
peroxiredoxin 4
phosphoglycerate kinase 4
arginase 4
factor C 4
complex I 4
aldehyde dehydrogenase 4
histidine decarboxylase 4
endoglycosidase H 4
arachidonate 5-lipoxygenase 4
adenylate cyclase 4
caspase-7 4
cysteine synthase 4
DNA ligase 4
aldehyde dehydrogenase 4
DNA ligase 4
aldehyde dehydrogenase 4
RNase H 4
polo-like kinase 1 4
hexosaminidase 4
chondroitinase 4
5'-nucleotidase 4
AST 4
isocitrate dehydrogenase 4
more...
Compound
BCR 2720
ABL 2629
DNA 1442
Dec 1313
Clin 1100
tyrosine 648
lysine 379
oxygen 234
ATP 198
glucose 177
MTT 152
retinoic acid 128
water 116
calcium 113
Ara-C 107
sodium 98
acetate 95
Ara-C 92
phosphate 90
serine 86
His 86
Busulfan 76
iron 73
threonine 72
arginine 72
TBI 72
Tyrosine 70
Hydroxyurea 62
MEK 59
cysteine 57
leucine 56
iodine 54
methionine 50
TNF 49
pentosidine 48
GTP 48
Methotrexate 46
pyrimidine 44
SDS 44
pyrimidine 43
Phe 43
hydrogen 43
VP-16 42
ADP 41
bromide 41
LTC4 40
sulfate 40
silver 39
galactose 37
GSH 37
GSH 37
nitrogen 36
ADP 35
TEL 35
ADP 35
Cyclosporine 34
AGE 33
MDA 33
creatinine 33
PEG 32
urea 32
methanol 31
MTX 30
Optimal 30
CTX 30
zinc 29
benzene 29
THP 28
nitric oxide 28
THP 28
Pac 28
Homoharringtonine 27
PAS 27
copper 25
Asp 25
Ile 25
salt 25
PEG 24
alanine 24
acridine 23
ethanol 23
GMP 22
5-Aza-2'-deoxycytidine 22
DMSO 21
Adriamycin 21
ammonium 21
NH2 21
Indirubin 20
AMP 20
boron 20
ADR 20
TPA 20
TPA 20
Curcumin 19
nitrate 19
GlcNAc 19
H2O2 18
N-acetylcysteine 18
phosphorus 18
DFS 18
GalNAc 17
pyridine 17
NAD 17
CO2 17
Mitoxantrone 17
potassium 17
FK506 17
Tiazofurin 17
acetonitrile 16
MDR 16
Mitoxantrone 16
TEM 16
EDTA 16
isoleucine 15
homocysteine 15
PMA 15
DEAE 15
EDTA 15
PMA 15
prostaglandin E1 15
NAD 14
isoleucine 14
cAMP 14
tryptophan 14
ACS 14
CBS 14
Cbl 14
MTS 13
diacetate 13
proline 13
DPG 13
tryptophan 13
ACS 13
MCNU 13
DBM 12
aldehyde 12
Hypaque 12
nicotinamide 12
chromium 12
acetone 12
selenium 12
COS 12
vitamin D 12
Isoproterenol 12
DCC 12
Gly 12
tryptophan 11
benzamide 11
tryptophan 11
CMP 11
KT-1 11
6-12 11
Cardiol 11
uridine 11
CMP 11
ADP-ribose 11
m-AMSA 10
glycerol 10
dUTP 10
aldehyde 10
more...