Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The extent of length heteromorphisms of the human Y chromosomes was measured in 50 patients with chronic myelogenous leukemia and was compared with 50 normal controls. No significant difference (p greater than 0.05) in the size of the Y chromosome was noted between these two groups. These findings differ from an earlier investigation, where a longer heterochromatic segment of Y chromosome was noted in malignant tumors and it was stressed that constitutive heterochromatin plays a role in susceptibility of cancer. Present investigation, however, suggests that this is not the case in patients with chronic myelogenous leukemia.
 ...
PMID:Length polymorphisms of the human Y chromosome in patients with chronic myelogenous leukemia. 346 79

The nonrandomness of chromosome clonal evolution in blastic crisis of chronic myeloid leukemia is well established, with three major changes [+8, +Ph, i(17q)] occurring alone or in combination in over 70% of the patients. The chromosome changes observed in different tissues may reveal the origin of the abnormal clones, as well as provide evidence for distinct or common evolution by different cell populations. The significance of the chromosome abnormalities and their relationship to blastic conversion are discussed. In general, chromosome evolution may be considered a rather reliable predictive or diagnostic parameter of blastic crisis but both the nature and the subsequent behavior of abnormal clones appear to be of critical value. As to the clinical/chromosome correlations, a few major points have emerged: the i(17q) aberration is mostly associated with signs of myeloid differentiation of blasts and a marked basophilia; it is mainly observed in the late stage of the disease, but overall median survival of patients with this marker is usually long; more atypical or complex changes usually are associated with a worse prognosis; patients with only a Ph in their blasts may have a longer survival, at least in some cytologic subgroups; and d) the loss of the Y chromosome seems to protect the cell against further clonal evolution. Finally, the relevance of the chromosome changes in the multistage process of blastic conversion is discussed, and the breakpoints of secondary changes recorded so far are reviewed and examined. It appears that certain chromosome regions are more often affected; these might contain genes of critical importance for the final malignant progression. Molecular biology may provide insight, in the future, on the nature and expression of involved genes.
 ...
PMID:The karyotype of blastic crisis. 347 Jan 35

The findings presented indicate that splenectomy during the blastic phase (BP) of Philadelphia (Ph) positive chronic myeloid leukemia (CML) prolonged survival after the onset of the BP in a group of patients who had, in addition to the Ph, only chromosomally abnormal cells in the marrow (AA patients). To evaluate the predictive parameter for splenectomy in the chronic phase (CP) of CML, the cytogenetic data obtained during the CP of the AA group were compared retrospectively with those of cytogenetically defined groups. Only AA patients showed the presence of abnormal clone(s) containing abnormalities such as trisomy 8, i(17q), and a missing Y chromosome several years before the onset of BP. This may indicate that the presence of these chromosome abnormalities during the CP could be utilized as a predictive parameter for splenectomy in the CP of CML.
 ...
PMID:Chromosome changes and splenectomy in Ph-positive CML. III. Predictive parameters in the chronic phase. 385 66

This article documents the cytogenetic findings in 79 patients with typical Ph-positive chronic myelocytic leukemia (CML). Direct preparations of bone marrow and/or peripheral blood of 46 males and 33 females were studied with different banding techniques. Seventy patients were studied during chronic phase. Three (4.3%) had unusual or complex translocations: t(6;22)(p21;q11), t(8;12;9;22)(p21;q21;q34;q11), and t(9;11;22)(q34;q13;q11). One (1.4%) had a +Ph, 1 (1.4%) had a +8, 1 (1.4%) had a del(3)(p13,p23), and 4 of 30 males (13.3%) showed loss of Y chromosome. Five of 8 cases studied during blast crisis had additional abnormalities. The +8 occurred in 4 cases, +10 and +19 each in 3 cases, +6, + 9q+, and +13 each in 2 cases, and +5, +11, +14, +21, +Ph, i(17q), dic(1;9), and structural abnormalities of chromosomes #1, #5, #12, and #13 each in 1 case. Two cases studied in blast crisis alone had complex translocations leading to the Ph. Because it cannot be ruled out that these translocations are secondary, they were not included in the calculation of the frequency of atypical translocations.
 ...
PMID:Philadelphia chromosome (Ph) positive chronic myelocytic leukemia (CML): frequency of additional findings. 385 71

Two cases of chronic myeloid leukemia in which the cytogenetic clone was 45, XO, Ph(1) are described and compared with 20 cases recorded in the literature. The 45, XO line is peculiar to the leukemic cells and is not a manifestation of constitutional mosaicism. It probably arises from a 46, XY, Ph(1) line by loss of the Y chromosome. Because of the few cases reported, one cannot be certain that these men have a better prognosis, although the median survival time suggests that this is so. Infertility is not part of this disorder.
 ...
PMID:Males with chronic myeloid leukemia and the 45, XO, Ph1 chromosome pattern. 452 33

We encountered a 38-year-old Japanese male patient with chronic myelogenous leukemia (CML), whose bone marrow and peripheral blood cells during the chronic and blastic phases contained a complex Ph1 translocation and an extra Y chromosome [i.e., 47,XYY,t(9;22;13)(q34;q11;q14)]. A karyotypic analysis of PHA-stimulated lymphocytes showed the constitutional karyotype to be 47,XYY. Thus, it was considered that CML with a complex Ph1 translocation developed in an XYY male; such a case has not been reported, so far. A B-lymphocyte cell line with the complex Ph1 translocation was established by the procedure of Epstein-Barr virus transformation. The presence of the complex Ph1 translocation in the B-lymphocyte cell line suggests that some of the B lymphocytes in this patient originated from the CML clone.
 ...
PMID:Chronic myelogenous leukemia with a complex Ph1 translocation in an XYY male. 660 1

A 42-year-old man with chronic myelogenous leukemia for ten years was found to have a 45 XO Philadelphia chromosome karyotype in myeloid cells with normal 46 XY pattern in peripheral blood lymphocytes. This chromosome pattern has been postulated to be associated with delay in onset of blastic transformation. The prolonged survival of this patient, with only minimal initial chemotherapy and lack of symptoms for ten years, lends support to the concept that the missing Y chromosome may be associated with a favorable prognosis in Philadelphia chromosome-positive men with chronic myelogenous leukemia.
 ...
PMID:Chronic myelogenous leukemia. Association with 45 XO Philadelphia chromosome karyotype and prolonged survival. 692 98

Karyotypes were examined in 56 cases of Ph1-positive hematologic disorders based on direct examination of bone marrow material and culture of blood for 24 hr without phytohemagglutinin (PHA). Various banding techniques (Q, followed by R or C, where necessary) were used. The series of patients consisted of 21 females and 35 males with the ages ranging from 3 to 72 years. In three cases, the clinical and hematologic picture at the time of diagnosis and karyotyping was not compatible with chronic myeloid leukemia (CML): 1 case had acute myeloblastic leukemia (AML), another acute lymphoblastic leukemia (ALL) and the third subacute myeloid leucosis. The results are as follows: In three cases (two female, one male), no Ph1 translocation could be demonstrated in any of the metaphases either with Q- or R-banding. In 50 cases (19 female, 31 male), a standard Ph1 translocation, t(9;22)(q34;q11), was observed. In two of these cases, ages 45 and 47, the Ph1 translocation was accompanied by loss of the Y chromosome in all the metaphases examined. Finally, in three cases (all male), variant Ph1-translocations were found: t(7;9)(9;22)(q35?;q31?;q11), and t(1;9)(9;22)(q21;134;q11).
 ...
PMID:Cytogenetic studies in 56 cases with Ph1-positive hematologic disorders. 695 Aug 5

Y chromosome duplication appeared in a patient with chronic myeloid leukaemia (CML) during blastic crisis. Additional chromosome changes were present. Y chromosome duplication may be a minor route of karyotype evolution in CML.
 ...
PMID:Y chromosome duplication in chronic myeloid leukemia. 695 Nov 42

Two patients with chronic myelogenous leukemia and new variant Philadelphia chromosome translocations are reported. In one case, a 41-year-old male, a 10;22 translocation was found in all bone marrow cells examined. Furthermore, the Y chromosome was missing in 90% of the analyzed metaphase cells. In the second patient, a 22-year-old male, all the marrow cells contained a complex rearrangement involving chromosomes No. 2, 9 and 22.
 ...
PMID:Variant Philadelphia chromosome translocations in two patients with chronic myelogenous leukemia. 695 58


<< Previous 1 2 3 4 5 Next >>