Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
p15INK4B
, a cyclin-dependent kinase inhibitor, has been recognized as a tumor suppressor. Loss of or methylation of the
p15INK4B
gene in
chronic myeloid leukemia
(
CML
) cells enhances myeloid progenitor formation from common myeloid progenitors. Therefore, we examined the effects of overexpressed
p15INK4B
on proliferation and apoptosis of
CML
cells. Overexpression of
p15INK4B
inhibited the growth of K562 cells by downregulation of cyclin-dependent kinase 4 (CDK4) and cyclin D1 expression. Overexpression of
p15INK4B
also induced apoptosis of K562 cells by upregulating Bax expression and downregulating Bcl-2 expression. Overexpression of
p15INK4B
together with STI571 (imatinib) or BCR-ABL1 small interfering RNA (siRNA) also enhanced growth inhibition and apoptosis induction of K562 cells. The enhanced effect was also mediated by reduction of cyclin D1 and CDK4 and regulation of Bax and Bcl-2. In conclusion, our study may provide new insights into the role of
p15INK4B
in
CML
and a potential therapeutic target for overcoming tyrosine kinase inhibitor resistance in
CML
.
...
PMID:A combination of STI571 and BCR-ABL1 siRNA with overexpressed p15INK4B induced enhanced proliferation inhibition and apoptosis in chronic myeloid leukemia. 2538 78
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