Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic myelogenous leukemia (CML)
is a myeloproliferative disorder defined by the presence of the fusion gene BCR-ABL1 in primitive hematopoietic progenitors. The myeloid leukemia factors (MLFs) were identified in the fly and human, and are involved in acute leukemia and enhancing the myeloid factor; however, the function of
MLF2
in
CML
is poorly understood. In this study, we demonstrated that
MLF2
may play an oncogenic role in
CML
. The expression level of
MLF2
was related to the proliferation, colony-formation ability, and sensitivity to imatinib in K562 cells. Moreover, phosphorylation at serine 24, detected through Phos-tag sodium dodecyl sulfate-polyacrylamide gel electrophoresis, was required to maintain the activity of
MLF2
in
CML
. The effects of
MLF2
overexpression on the colony-formation ability in vitro and mouse survival in vivo could be alleviated by point mutation of
MLF2
at serine 24. These findings uncover the oncogenic role of
MLF2
through phosphorylation at serine 24 and provide a novel therapeutic target in
CML
.
...
PMID:The role of phosphorylation of MLF2 at serine 24 in BCR-ABL leukemogenesis. 3183 54
