Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We investigated the peripheral blood gene expression profile of
interferon induced transmembrane protein 1
(
IFITM1
) in sixty
chronic myeloid leukemia
(
CML
) patients classified according to new prognostic score (NPS).
IFITM1
is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of
IFITM1
was found significantly different between the high- and low-risk groups (P = 9.7976 x 10(-11)) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher
IFITM1
expression correlated with improved survival (P = 0.01). These results indicate that
IFITM1
expression profiling could be used for molecular classification of
CML
, which may also predict survival.
...
PMID:Expression of IFITM1 in chronic myeloid leukemia patients. 1566 Dec 63
