Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Early diagnosis and cure for patients with
chronic myeloid leukemia
(
CML
) exhibit significant clinical challenges because of the disease progression from chronic phase (CP) into a rapidly fatal blast crisis. Our earlier studies suggested an association of sperm associated antigen 9 (SPAG9) with various human malignancies. The present investigation revealed that SPAG9 mRNA and protein are expressed in
CML
patients (88%), in K562 and KCL-22 cells. Further,
SPAG9 protein
expression was also detected on cell surface suggesting that this molecule may be a suitable target for immunotherapy. Interestingly, 90%
CML
-CP patients showed humoral response against SPAG9, suggesting its important role in early diagnostic of
CML
-CP. Further investigation is warranted in establishing the potential of SPAG9 as a biomarker and immunotherapeutic target for early treatment of
CML
-CP patients.
...
PMID:Sperm associated antigen 9 expression and humoral response in chronic myeloid leukemia. 2013 65
