Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Argininosuccinate synthetase
(
ASS
) activity is hardly detected in human lymphocytes. In this study, we examined the
ASS
gene expression of various leukemia cells by a polymerase-chain-reaction method. We demonstrate here that (a) acute lymphocytic and acute myelocytic leukemia cells exhibit the highly elevated expression of the
ASS
gene and (b)
chronic myelocytic leukemia
(
CML
) in blastic crisis also exhibits the increase of
ASS
gene expression while
CML
in chronic phase, chronic lymphocytic leukemia and adult T leukemia cells show the similar level to that of normal lymphocytes. These results suggest that the
ASS
gene expression is of value as a diagnostic marker of acute type leukemia, particularly for blastic crisis of
CML
.
...
PMID:Argininosuccinate synthetase gene expression in leukemias: potential diagnostic marker for blastic crisis of chronic myelocytic leukemia. 162 73
