Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bcr-Abl is the primary cause as well as currently key therapeutic target of
chronic myeloid leukemia
(
CML
). SKP2, an E3 ligase, is a downstream factor of Bcr-Abl to motivate the cell cycle transition of
CML
and also found to bind and activate Bcr-Abl in reverse. Therefore, SKP2/Bcr-Abl pathway is an attractive target for
CML
treatment. This study aims to identify an inhibitor of the SKP2/Bcr-Abl pathway based on a large screening of the natural products. We demonstrate that
Diosmetin
, a kind of phytoestrogens, notably downregulates the expression of SKP2, Bcr-Abl phosphorylation, and moderately downregulates the Bcr-Abl level. Furthermore,
Diosmetin
displays a favorable anti-tumor activity in
CML
cells and xenograft models. Collectively, our study reveals a natural compound in the treatment of
CML
on the basis of SKP2/Bcr-Abl signaling pathway.
...
PMID:Targeting SKP2/Bcr-Abl pathway with Diosmetin suppresses chronic myeloid leukemia proliferation. 3267 84
