Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and
PPP1CB
were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-
PPP1CB
fusion is not specific for CLL but is also detected in other hematological malignancies such as
chronic myeloid leukemia
, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5-
PPP1CB
fusion is a good drug target in CLL or a suitable target to monitor disease.
...
PMID:The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples. 2660 51
