Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of platelet counts, hematocrit, and leukocyte counts were studied on the closure times of the Thrombostat 4000 (in-vitro bleeding time, IVBT). Closure times became longer with platelet counts < 50 x 10(9)/L; an inverse linear correlation could be established. Hematocrit was also inversely correlated with the closure time. At constant platelet counts a hematocrit of 55% yielded an immediate closure of the filter, while with a hematocrit < 15% no closure times could be measured. At constant platelet counts and hematocrits, nomonuclear and polymorphonuclear leukocytes also influenced closure times; increased counts resulted in shorter closure times. Leukocytes from a patient with chronic myelocytic leukemia had the same effects.
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PMID:Hematological parameters influencing the Thrombostat 4000. 766 Jan 53