Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Benzoporphyrin derivative
(
BPD
) and light is a potent photosensitizer. We investigated this modality as a means to selectively eliminate clonogenic Ph(+)
chronic myeloid leukemia
(
CML
) cells.
BPD
at 10 ng/ml and 10.8 J/cm2 broad spectrum light eliminates from 5 to 6 logs of Ph(+) EM-2 cells. Long-term marrow culture studies of treated mixtures of normal and
CML
cells indicate that multipotent progenitor cell viability is retained while cells transcribing BCR-ABL are not detected. We conclude that
BPD
and light may offer a means of providing
CML
autografts potentially free of Ph(+) clonogenic cells.
...
PMID:Photodynamic elimination of clonogenic Ph+ chronic myeloid leukemia cells. 825 8
