Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

About 950 genes (or a part of them) have been cloned. Using them as probes, DNA diagnosis is now available in hundreds of hereditary diseases and some malignant diseases. In many of them, detailed analysis into the mechanisms underlying the diseases has become possible. Examples of this capability include 21 hydroxylase deficiency, amyloid polyneuropathy, Duchenne/Becker muscular dystrophy, and CML. About one third of the cloned genes show RFLPs (restriction fragment length polymorphisms). In addition "random" DNA fragments have been cloned, many of them can also be used to detect RFLPs. An RFLP study has proven very useful in the preclinical/prenatal diagnosis of hereditary diseases even though gene-action is unknown (e.g., Huntington disease and von Recklinghausen disease). DNA diagnosis has also been found to be very useful in the detection of microorganisms, minute chromosome changes (e.g., XX males) and for forensic purposes. The techniques and understanding of DNA diagnosis have become mandatory in many areas of medicine.
 ...
PMID:[DNA diagnosis in medicine]. 197 43

The chronic myeloproliferative disorders (MPD) comprise polycythemia vera (PV), idiopathic thrombocythemia (IT), chronic myeloid leukemia (CML) and myelofibrosis/osteomyelosclerosis (MF/OMS). Bone marrow biopsies of 3500 patients with known or suspected MPD were studied, and the clinical and morphologic variables registered were utilized for multivariate data analysis by selected BMD computer programs. The histologic criteria and the histologic subdivisions, as well as the evolution and prognosis of disease are outlined for each of the clinical entities. The results show that a bone marrow biopsy provides independent diagnostic and prognostic data in this group of hematologic malignancies and therefore constitutes an additional parameter in the diagnostic investigation of patients with suspected or established MPD.
 ...
PMID:Potential of bone marrow biopsy in chronic myeloproliferative disorders (MPD). 843 14