Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We measured the numbers of B- and T-lymphocytes in the peripheral blood of 40 patients with chronic granulocytic leukemia (CGL) at different stages in the chronic or stable phase of the disease. In untreated patients and in treated patients with relatively high leukocyte counts, T-cell numbers were increased: in the majority of cases this increase involved both "helper" (OKT4+) and "suppressor" (OKT8+) cells. B-cell numbers were normal. Patients whose leukocyte counts had been restored to normal by treatment with cytotoxic drugs had normal T-cell numbers, but B-cell numbers were reduced in comparison with normal persons. We conclude that untreated CGL is usually associated with a T-cell lymphocytosis that can be reversed by chemotherapy. The excess of T-lymphocytes in the blood before treatment is probably an immunological response to the neoplastic proliferation, but the possibility that some T-lymphocytes might be involved in the malignant clone cannot be excluded.
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PMID:Increased T-lymphocyte numbers in chronic granulocytic leukemia before treatment. 623 87

We report a rare case of haemorrhagic colitis attributed to dasatinib therapy in a 47-year-old African-American woman who was diagnosed with extramedullary T-lymphoblastic transformation of chronic myeloid leukaemia. The patient received intensive chemotherapy and dasatinib 100 mg/day. After achieving complete cytogenetic and major molecular response after 9 months of therapy, she developed bloody diarrhoea and pancytopenia. Colonoscopy showed inflammation of the descending colon and histopathology revealed patchy increase in intraepithelial lymphocytes. Dasatinib was stopped with prompt resolution of diarrhoea. The current literature suggests that there is an association in a subset of patients on dasatinib between clonal T-cell lymphocytosis in the peripheral blood and developing colitis and pleural effusions. These patients had a good response to dasatinib as did our patient. Our patient illustrates a unique disease presentation along with a rare drug adverse event.
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PMID:Dasatinib-induced haemorrhagic colitis in chronic myeloid leukaemia (CML) in blast crisis. 2433 70