Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Imatinib is presently the commonest prescribes drug for patients of
chronic myelogenous leukemia
(
CML
) in chronic phase (CP) worldwide. Its ocular side effects are little known.
Optic neuritis
caused by this drug has not been reported (Medline search). We describe perhaps the first case of
optic neuritis
caused by this drug.
...
PMID:Imatinib-induced optic neuritis in a patient of chronic myeloid leukemia. 1741 Mar 37
A 49-year-old woman diagnosed with
chronic myeloid leukemia
in the chronic phase was started on dasatinib treatment, after which she complained of myodesopsia. Nineteen months after diagnosis, the patient again complained of myodesopsia and developed bilateral
optic neuritis
. Cerebrospinal fluid analysis revealed an increase in blasts, although peripheral blood and bone marrow examination confirmed that the patient remained in a molecular response to tyrosine kinase inhibitor (TKI) therapy. The patient was diagnosed with an isolated central nervous system blast crisis, a rare occurrence with second-generation TKI therapy, and the initial presentation of myodesopsia represented a symptom of this condition.
...
PMID:Myodesopsia is a symptom of central nervous system blast crisis in chronic myeloid leukemia. 3091 63
