Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
Wilms' tumor
1 (
WT1
) gene is an important regulatory molecule that plays a vital role in cell growth and development. Initially, knowledge of
WT1
was mostly limited to
Wilms' tumor
. Over the past years, numerous studies have shown that
WT1
is aberrant expressed or mutated in hematopoietic malignancies, including acute leukemia (AL), myelodysplastic syndrome (MDS) and
chronic myelogenous leukemia
(
CML
). Currently, many studies focus on exploring the role of
WT1
in hematopoietic malignancies. Such studies improve the understanding of hematopoietic malignancies, and the collection of data about
WT1
expression or mutation in hematopoietic malignancies over the past years can facilitate the risk stratification of hematopoietic malignancies. In this review, we highlight the important role of
WT1
in hematopoietic malignancies, discuss its potential clinical applications as a minimal residual disease (MRD) and prognostic biomarker, and evaluate the possible therapy target of
WT1
in hematopoietic malignancies.
...
PMID:Wilms' tumor 1 gene in hematopoietic malignancies: clinical implications and future directions. 3240 Nov 9
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