Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Disseminated atypical mycobacterial infection has been reported mainly in patients with AIDS and hairy cell leukemia. We describe three patients with chronic myelogenous leukemia (CML) who developed disseminated atypical mycobacterial infection in the chronic stage of their disease. The incidence of the latter infection is 3.9% among patients with CML at our institution; such a high incidence has never before been reported. There are no specific signs or symptoms other than fever. The bone marrow is the culture site most often useful in diagnosis. An immunologic defect may be one of the features of CML. Clinicians must thus be aware of the possibility of disseminated atypical mycobacterial infection in patients with CML.
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PMID:Systemic infection due to atypical mycobacteria in patients with chronic myelogenous leukemia. 196 89

Allogeneic bone marrow transplant recipients are prone to pulmonary infections caused by a wide spectrum of organisms. Since the first bone marrow transplatation (BMT) done in 1983 at the Tata Memorial Hospital, we have recently seen the first case of Mycobacterium Fortuitum Chelonae complex among 117 BMT (including 90 allogeneic and 27 autologous) patients. The patient was on immunosuppressants for chronic GVHD post allogeneic BMT done for CML-CP. He developed pulmonary mycobacterial infection 13 months post BMT. Diagnosis was difficult because of the atypical presentation, negative culture reports, and the presence of multiple pathogens due to immunosuppression. In our case the diagnosis was eventually established after examination of material obtained by bronchoscopy. Patient has shown response to antituberculosis drugs after 2 months. This shows the need to consider atypical mycobacterial infection in the differential diagnosis of pulmonary illness in the post allogeneic BMT setting.
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PMID:Mycobacterial pulmonary infection post allogeneic bone marrow transplantation. 1142 41