Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sudden sensorineural hearing loss that presents as the initial sign of haematological disease is very rare. Chronic myelogenous leukaemia has been implicated as a causative factor of sudden sensorineural hearing loss. A 49-year-old male presented with unilateral sudden sensorineural hearing loss. The patient was found to have chronic myelogenous leukaemia during a work-up for his hearing loss. We present a case of a chronic myelogenous leukaemia patient whose first manifestation was sudden sensorineural hearing loss. We presume that cochlear vessel occlusion as a result of elevated blood viscosity was responsible for this patient's hearing loss. Early onset of sudden deafness in a chronic myelogenous leukaemia patient may be due to the hyperviscosity syndrome and it may be possible to reverse hearing loss through early leukapheresis.
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PMID:Sudden hearing loss in chronic myelogenous leukaemia implicating the hyperviscosity syndrome. 1194 92

Hearing loss and blindness rarely occur in patients with chronic myeloid leukemia (CML). In this article, we present a 12-year-old girl who had right-side hearing loss as the initial manifestation of CML, followed by left-side hearing loss and blindness of the left eye several days after initiating treatment. The initial white cell count was 181,700/mm3. Audiometry showed severe sensorineural hearing loss of her right ear and moderate mixed hearing loss of the left ear. An ophthalmic examination showed optic neuropathy with subhyaloid hemorrhage in the left eye. A brain magnetic resonance image showed minor hemorrhaging in the right lower frontal area and anterior thalamus. These findings might have implied leukostasis with hyperviscosity syndrome. She died on the 9th hospital day. This case illustrates that CML should be considered 1 of the rare diagnoses in a patient with sudden onset of hearing loss.
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PMID:Sudden hearing loss as the initial manifestation of chronic myeloid leukemia in a child. 1555 12

Imatinib (Gleevec) is a biological agent that is approved for the treatment of chronic myeloid leukemia (CML) as well as gastrointestinal stromal tumor (GIST). The most frequently seen adverse effects in patients treated with imatinib include superficial edema, muscle cramps, musculoskeletal pain, rash, fatigue, headache, abdominal pain, and joint pain. Ototoxicity has rarely been reported except in two cases. We report a case of bilateral irreversible sensorineural hearing loss (SNHL) caused by imatinib in a patient receiving this agent in the adjuvant setting. This case underlines the importance of early recognition of this potential toxicity that can impact the quality of life.
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PMID:Imatinib-induced Ototoxicity in a Patient with Gastrointestinal Stromal Tumor (GIST). 2790 36

Bilateral sensorineural deafness and unilateral cochlear ossification have rarely been described in patients with chronic myeloid leukemia (CML). A 21-year-old man presented to a hospital with right-sided sudden hearing loss and tinnitus. He was diagnosed with CML. Five days later, sudden hearing loss appeared in the other ear. Abnormality of the right-sided inner ear structure was revealed by preoperative magnetic resonance imaging; honeycomb-like cochlear ossification was observed during cochlear implant surgery in the right ear. The patient's auditory performance exhibited significant improvement after bilateral cochlear implantation in our hospital. Hematological disorders must be considered in patients with sensorineural hearing loss. Cochlear implantation is feasible in patients with CML who exhibit sensorineural deafness, but cochlear ossification should be carefully evaluated by means of preoperative imaging examinations.
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PMID:Bilateral Hearing Loss and Unilateral Cochlear Ossification in a Patient With Chronic Myelogenous Leukemia. 3297 Apr 97