Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023473 (chronic myeloid leukemia)
 18,916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 81-year-old woman was admitted, complained general malaise, and edema on face and lower extremities. In the peripheral blood, leucocytosis (17,220/mm3), microcytic hypochromic anemia (RBC 348 x 10(4)/mm3, Hb 9.6 g/dl, Ht 29.2%), and thrombocytosis (130 x 10(4)/mm3) were present, and many myeloid cells containing of myeloblasts, promyelocytes and so on were observed. Bone marrow aspiration revealed increment of the myeloid series without hiatus leukemia . The Neutrophil Alkaline Phosphatase score and rate was low, and on bone marrow scintigram using indium chloride, liver and extremities were shown. On admission, proteinuria (21.5 g/dl) and hypoalbuminemia (2.5 g/day) were pointed out, and the renal biopsy specimen showed membraneous proliferative glomerulonephritis (MPGN), so we diagnosed this case that chronic myelogenous leukemia (CML) complicated with nephrotic syndrome. At first, she was treated with prednisolone, but proteinuria was not entirely improved, then busulfan was given, myeloid cells in peripheral blood were disappeared and proteinuria was gradually decreased. From this coarse, the causality between CML and nephrotic syndrome was verified.
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PMID:[A case of chronic myelogenous leukemia complicated with nephrotic syndrome]. 252 82

In three groups of patients with hypochromic anemia, chronic myelocytic leukemia and chronic lymphatic leukemia, the fibrinolytic activity, kininogen level and kininase activity in the peripheral blood and bone marrow punctates were analyzed. In patients with anemia and myelocytic leukemia similar, unchanged kininase activity, significantly higher fibrinolytic activity and lower kininogen content were found in bone marrow as compared to the peripheral blood samples. In cases of lymphatic leukemia the fibrinolytic activity and kininogen levels did not show significant difference in the blood and bone marrow, while a significantly decreased blood kininase activity was followed by a similarly low activity of the bone marrow punctate. The differences found may result from an enzymatic effect of juvenile forms of granulocytes and of the lymphoreticular system.
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PMID:Comparative studies on the kinin-forming system in the bone marrow punctates and in the peripheral blood in cases of certain hematological diseases. 694 31