Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023473 (
chronic myeloid leukemia
)
18,916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aberrant methylation of tumour suppressor genes is associated with the progression to a blast crisis in
chronic myeloid leukaemia
(
CML
).
Methyl-CpG-binding domain protein 2
(
MBD2
) has been studied as a "reader" of DNA methylation in many cancers, but its role in
CML
is unclear. We constructed cell models of a homozygous deletion mutation of
MBD2
using gene-editing technology in K562 cells and BV173 cells. Here, we demonstrated that the deletion of
MBD2
inhibited cell proliferation capacity in vitro.
MBD2
deletion also significantly inhibited K562 cell proliferation in a xenograft tumour model in vivo. Additionally, the JAK2/STAT3 signalling pathway, which is abnormally active in
CML
, was inhibited by
MBD2
deletion, and
MBD2
deletion could up-regulate the expression of SHP1. In conclusion, our findings suggest that
MBD2
is a candidate therapeutic strategy for the
CML
blast phase.
...
PMID:Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells. 2956 10
