Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023467 (acute myeloid leukemia)
 35,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 49-year-old woman presented with a 1-year-history of a widespread eruption which proved to be due to leukaemia cutis. Subsequently, she developed pancytopaenia and a bone marrow biopsy revealed refractory anaemia with excess blasts in transformation (RAEB-T) with a high monoblastic component. This transformed into acute myeloid leukaemia. Leukaemia cutis in this context is well described but in this patient it became manifest 1 year prior to referral to the dermatologist. When occurring with a myelodysplastic syndrome, leukaemia cutis often heralds malignant transformation to acute myeloid leukaemia. Prompt diagnosis in this situation may identify a group of high-risk patients with myelodysplastic syndrome for whom chemotherapy and allogenic bone marrow transplantation, rather than the more conventional approach of supportive treatment, could be a more appropriate management strategy.
Clin Exp Dermatol 2004 Sep
PMID:A case of monocytic leukaemia cutis in a patient with myelodysplastic syndrome transforming to acute myeloid leukaemia. 1534 35

Cutaneous lymphomas are rare in young patients and are mostly represented by mycosis fungoides and its variants and CD30+ lymphoproliferative disorders (lymphomatoid papulosis [LYP] and anaplastic large T-cell lymphoma). We report our observations in a series of 69 patients less than 20 years of age who presented either with primary cutaneous lymphoma (n = 62) or with secondary manifestations of extracutaneous disease (n = 7). Clinicopathologic features permitted classification of the cases into the following diagnostic categories: mycosis fungoides (n = 24, all primary cutaneous), anaplastic large T-cell lymphoma (n = 13, all primary cutaneous), LYP (n = 11, all primary cutaneous), subcutaneous "panniculitis-like" T-cell lymphoma (n = 1, primary cutaneous), small-medium pleomorphic T-cell lymphoma (n = 2, all primary cutaneous), natural killer (NK)/T-cell lymphoma, nasal-type (n = 1, secondary cutaneous), follicle center cell lymphoma (n = 1, primary cutaneous), marginal zone B-cell lymphoma (n = 7, all primary cutaneous), B-lymphoblastic lymphomas (n = 6, 3 primary and 3 secondary cutaneous), specific cutaneous manifestations of Hodgkin disease (n = 1, secondary cutaneous), and acute myeloid leukemia (n = 2, both secondary cutaneous). Cutaneous lymphoma in children should be differentiated from benign skin disorders that may simulate them. In particular, mycosis fungoides and LYP in this age group may present with clinicopathologic features reminiscent of inflammatory disorders such as pityriasis alba, vitiligo, pityriasis rosea, and pityriasis lichenoides et varioliformis acuta. Even in secondary cutaneous lymphomas, skin manifestations may be the first sign of the systemic disease, and a diagnosis may be achieved on examination of histopathologic specimens of a cutaneous lesion. Our study illustrates the wide spectrum of cutaneous lymphomas and leukemias in patients less than 20 years of age and underlines the need for proper interpretation of these lesions by dermatologists and dermatopathologists.
Pediatr Dermatol
PMID:The spectrum of cutaneous lymphomas in patients less than 20 years of age. 1546 55

Cytarabine, used for the treatment of acute myelogenous leukemia, can cause a rare reaction of inflammation of existing seborrheic keratoses. We report a case of cytarabine induced inflammation of seborrheic keratoses mimicking a vesicular eruption in 53-year-old man with acute myelogenous leukemia.
J Drugs Dermatol
PMID:Inflammation of seborrheic keratoses caused by cytarabine: a pseudo sign of Leser-Trelat. 1555 12

A full-term 2-week-old boy was referred to the pediatric dermatology clinic with numerous blue to violaceous nodules present since birth. TORCH titers (against toxoplasmosis, cytomegalovirus, herpes simplex virus, rubella, and syphilis) were negative. Complete blood count and peripheral smear were normal. A skin biopsy specimen showed an atypical cellular infiltrate suspicious for leukemia or lymphoma. A bone marrow biopsy specimen demonstrated acute myelogenous leukemia (M4 subtype). Following consultation with pediatric oncology and the recognition of the potential for spontaneous regression, chemotherapy for the infant's condition was not recommended. He remained otherwise healthy and was followed-up with biweekly to monthly complete blood counts and physical examinations, which were repeatedly normal. By 3 months of age, the nodules had completely resolved and there was no evidence of recurrence at 8 months of follow-up. We report this instance of aleukemic congenital leukemia with spontaneous regression of leukemia cutis without therapeutic intervention.
Pediatr Dermatol
PMID:Spontaneous regression of aleukemia congenital leukemia cutis. 1566 Aug 93

A 29-year-old man received an autologous stem cell transplantation after myeloablation with busulfan and cyclophosphamide to treat his acute myeloid leukemia, a. Five days after retransfusion of stem cells, hyperpigmented, scaly lesions with occasional perpheral lichenoid papules developed in groins, axillae, genitalia, and elbows. Histology revealed a graft-versus-host-like reaction. Although the graft-versus-host reaction, by definition, requires allogeneic cells, similar lesions have been reported after autologous stem cell transplantation. The clinical course is usually mild and self-limited. Flexural graft-versus-host-like reactions after autologous stem cell transplantation have been reported in four patients.
J Dtsch Dermatol Ges 2003 Aug
PMID:[Graft-versus-host-like flexural eruption after autologous stem cell transplantation]. 1629 55

We describe a newborn infant who was born with a purpuric rash and subcutaneous nodules. Skin biopsies demonstrated acute myeloid leukemia. Cytogenetic studies revealed an 11q23 rearrangement. Initial bone marrow and cerebrospinal fluid examination did not demonstrate medullary or meningeal disease. Chemotherapy was initiated on the basis of the abnormal cytogenetic findings in the skin biopsy. Intensive chemotherapy was, given but the infant's leukemia progressed. The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively.
J Am Acad Dermatol 2006 Feb
PMID:Congenital leukemia cutis with subsequent development of leukemia. 1642 86

Neutrophilic eccrine hidradenitis typically manifests as erythematous plaques on the face, trunk, or extremities. This eruption has been associated with numerous factors, but most commonly is seen with chemotherapy, particularly cytarabine. We report a 73-year-old woman with acute myelogenous leukemia who developed rapidly expansive neutrophilic eccrine hidradenitis mimicking facial cellulitis only after a course of cytarabine was followed by granulocyte-colony stimulating factor. Prompt diagnosis is imperative to prevent prolonged antimicrobial therapy.
J Am Acad Dermatol 2007 Apr
PMID:Neutrophilic eccrine hidradenitis masquerading as facial cellulitis. 1710 94

In humans, Saccharomyces cerevisiae (baker's yeast) is found infrequently as a commensal of mucosal surfaces and rarely causes infections. We describe a case of cutaneous septic emboli developing in a patient with relapsing acute myeloid leukaemia M6 who had recently been treated with clofarabine. Yeast forms were seen on skin biopsy and S. cerevisiae was isolated from her Hickman line. We are not aware of any previous case reports of cutaneous emboli associated with this organism.
Clin Exp Dermatol 2007 Jul
PMID:Saccharomyces cerevisiae emboli in an immunocompromised patient with relapsed acute myeloid leukaemia. 1737 13

We report a case of an elderly female in remission from acute myelogenous leukemia that presented with a nonhealing enlarging asymptomatic nodule on her right thigh. A wide excision of the nodule and histological examination revealed myeloid sarcoma without evidence or overlap of leukemia cutis, which had been suspected from nodules that had developed early in the course of the disease. The patient subsequently underwent radiation therapy to the area with sustained clearance.
J Drugs Dermatol 2007 Apr
PMID:Myeloid sarcoma presenting as an isolated nodule in a patient with acute myelogenous leukemia. 1766 45

Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology, characterized by the presence of auto-antibodies to various cellular components and chronic inflammation of different organ systems. A number of susceptibility loci for SLE have been suggested in different populations, but the nature of the susceptibility genes and mutations is yet to be identified. The programmed cell death 1 gene (PDCD1) was considered to be one of the strongest candidate genes associated with SLE. Here, we analyzed 265 individuals for single-nucleotide polymorphisms (SNPs) in PDCD1, including 122 unrelated individuals affected with SLE and 143 random healthy volunteer individuals in Han Chinese. Genomic DNA was prepared from peripheral blood leukocytes and the SNPs were further confirmed by DNA sequencing. We found there were statistically significant differences in the distribution of genotypes at 7872 locus (OR = 0.59, 95%CI = 0.41-0.85) and 8162 locus (OR = 0.54, 95%CI = 0.37-0.78) between SLE and control. Genotype TT in 7872 locus (OR = 0.58, 95%CI = 0.34-1.00) and GG genotype in 8162 locus (OR = 0.46, 95%CI = 0.26-0.80) might be protective for SLE prevention. The associated SNPs might regulate the binding of some transcription factors, such as AML-1a, USF and MZF-1, suggesting a mechanism through which it can contribute to the predisposition of SLE.
Arch Dermatol Res 2008 Feb
PMID:Programmed cell death 1 genotypes are associated with susceptibility to systemic lupus erythematosus among Chinese. 1799 73


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>