Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023467 (acute myeloid leukemia)
 35,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 34-year-old woman developed a granulocytic sarcoma of the breast coincident with the development of acute myelogenous leukemia. Subsequent to the induction of leukemia remission, marrow relapse was preceded by development of breast and vaginal granulocytic sarcomas on two separate occasions. Granulocytic sarcoma is occasionally reported to involve reproductive organs, but the coexistence in two such organs is indeed rare. When granulocytic sarcoma occurs at other sites, it often precedes the development of overt leukemia. For this reason, granulocytic sarcoma should be considered in the differential diagnosis of a pelvic mass especially in a patient in whom blood smears reveal unusual or early forms.
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PMID:Coexistent breast and vaginal granulocytic sarcoma. 657 95

Granulocytic sarcoma of the skin is only rarely the initial manifestation of acute granulocytic leukemia. In the absence of systemic signs and symptoms of leukemia, routine histologic examination of granulocytic sarcoma may result in misdiagnosis. A case of granulocytic sarcoma preceding overt leukemia is reported in which the biopsy specimen was initially interpreted as granuloma faciale.
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PMID:Granulocytic sarcoma preceding overt granulocytic leukemia. 658 97

Chloromas are solid tumours resulting from the localised proliferation of myelogenous leukemia cells, and are frequently responsible for the initial manifestations of acute myelocytic leukemia. We report a patient with a thoracic extradural chloroma whose presentation with acute paraplegia led to the diagnosis of an unsuspected myelocytic leukemia. Early recognition of the etiology of the paraplegia and the underlying systemic involvement with leukemia resulted in an excellent neurological and hematological outcome. The previously described association of the 8:21 chromosomal translocation with a good prognosis is noted in our patient.
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PMID:Extradural chloroma with spinal compression--an unusual presentation of acute myelogenous leukemia. 659 9

Preleukemia is a well-defined syndrome of hematopoietic dysfunction that may antedate the development of acute myelogenous leukemia. Granulocytic sarcoma refers to neoplastic infiltration in the skin, composed of immature cells of the granulocyte series. We report two cases of granulocytic sarcoma in the setting of preleukemia. The clinical importance of these cases, as well as the cutaneous manifestations of leukemia and the clinical spectrum of granulocytic sarcoma, are presented.
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PMID:Granulocytic sarcoma. A new finding in the setting of preleukemia. 659 7

The case of a 35-year-old female patient with primary mandibular manifestation of myelosarcoma (chloroma) is reported. The clinical course and diagnostic and therapeutic measures are described. Myelosarcomas are rare and are considered specific lesions of an acute myeloid leukemia. In addition to systemic leukemia therapy, myelosarcomas frequently have to be treated surgically or by irradiation because of their specific tumor localizations.
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PMID:Mandibular myelosarcoma (chloroma): primary oral manifestation of promyelocytic leukemia. 659 70

Chloromas are an unusual finding in patients with acute or chronic granulocytic leukemia. The present report describes a man with acute myelogenous leukemia (AML) whose course was complicated by cutis verticis gyrata (CVG), a mediastinal mass, neuropathies, and hepatosplenomegaly as a result of visceral involvement. Leukemic tumors and organ infiltration developed independent of his hematologic status and resulted in significant morbidity and, eventually, mortality from gastrointestinal hemorrhage. Nevertheless, at least temporary control over these complications was achieved when they were managed as leukemic "sanctuaries" and treated with local irradiation.
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PMID:Cutis verticis gyrata: unusual chloromatous disease in acute myelogenous leukemia. 693 78

This report describes a patient with granulocytic sarcoma (chloroma) of the mediastinum who presented with esophageal obstruction. There was also pleural involvement and a malignant effusion. Acute myelogenous leukemia was diagnosed concomitantly. Pitfalls in diagnosis are discussed.
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PMID:Report of a patient presenting with esophageal obstruction. 695 51

Acute myeloblastic leukemia is suspected usually because of abnormalities of the peripheral blood or bone marrow. In some cases there may also be an extramedullary focus of leukemic cells called a chloroma or granulocytic sarcoma. On occasion, these tumor masses may precede any evidence of leukemia by months or years. They are often misdiagnosed as lymphomas or granulomas. We present here a case of acute myeloblastic leukemia that was preceded by a granulocytic sarcoma of the clavicle. The initial biopsy of the clavicle was thought to be consistent with Ewing's sarcoma. The patient was treated with systemic chemotherapy prior to gross marrow involvement. He has been in continuous complete remission 34 months after the start of chemotherapy and 44 months after the development of granulocytic sarcoma.
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PMID:Granulocytic sarcoma of the clavicle. 696 4

Granulocytic sarcoma is an uncommon tumor composed of granulocytic precursor cells. Because it occurs in a variety of clinical settings and because the tumor cells are primitive it is frequently unrecognized during life. This presentation details the authors' experience with 61 biopsy-proven granulocytic sarcomas. The patient age range was from 2 to 81 years (mean 48 years). In eight patients the tumors were multiple. Most common sites of involvement were bone, periosteum, soft tissue, lymph node and skin. Twenty-two tumors occurred in 15 patients with no known disease, 26 occurred in 24 patients with a known myeloproliferative disorder, and 13 occurred in 11 patients with proven acute myeloid leukemia. Thirteen of the 15 patients with no known disease developed acute leukemia in from one to 49 months after the biopsy of their tumors (mean 10 months). Most tumors occurring in patients with a known myeloproliferative disorder were associated with blast crisis. The authors' cases displayed a morphologic range from well-differentiated to those tumors that displayed virtually no evidence of differentiation by conventional microscopy. It was therefore not surprising that most tumors were originally diagnosed as lymphoma. Chloro-acetate esterase (CAE) stains were performed on 56 tumors and 47 were studied with antilysozyme immunoperoxidase technique. Fifty-six of the 57 specimens studied by either technique were positive. Antilysozyme immunoperoxidase stains were particularly useful in confirming the diagnosis.
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PMID:Granulocytic sarcoma: a clinicopathologic study of 61 biopsied cases. 702 56

Granulocytic sarcoma (chloroma) is an uncommon malignant neoplasm associated with myelogenous leukemias. Its appearance may precede the clinical manifestations of the acute leukemic phase by months to years. We report the CT findings of a case of bilateral intraorbital granulocytic sarcoma which preceded the blast phase of acute myelogenous leukemia (AML) and led to its diagnosis. An awareness of granulocytic sarcoma and its CT appearance may expedite the diagnosis of AML or prompt close monitoring of those cases of granulocytic sarcoma antedating the appearance of AML.
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PMID:Bilateral orbital granulocytic sarcoma (chloroma) preceding the blast phase of acute myelogenous leukemia: CT findings. 749 Dec 13


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