Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 6167
lymphoid 4071
Mol 3113
AML 2216
cytokine 2109
ALL 1959
HLA 1866
p53 1800
tyrosine kinase 1591
erythroid 1480
CD34 1430
caspase-3 1424
CD4 1402
Bcl-2 1309
BCR 1227
ABL 1162
interferon 1159
MLL 1123
CD8 1089
non-Hodgkin's lymphoma 1072
thymus 1024
granulocyte 863
glycoprotein 862
histone 836
env 835
gag 818
CML 807
CD19 793
hairy 769
all-trans 763
FAB 763
P-glycoprotein 695
NMR 666
IL-2 653
tumor necrosis factor 631
IgE 629
IFN 626
FLT3 625
fused 619
THP 604
cytochrome c 580
interleukin-2 559
AML1 556
ATP 554
IL-6 547
p21 546
CD33 542
CLL 530
RUNX1 525
HLA-DR 519
CSF 517
myeloperoxidase 516
c-myc 510
IL-3 508
p13 506
granulocyte colony-stimulating factor 504
AKT 495
hemoglobin 493
TEL 493
pol 488
CD38 484
GM-CSF 479
PML 474
CD20 471
CD10 464
Fas 458
proto-oncogene 452
PARP 451
PI3K 442
caspase-8 441
She 434
promyelocytic leukemia 432
esterase 427
granulocyte-macrophage colony-stimulating factor 427
ERK 425
MAPK 423
CD56 423
polypeptide 422
MOLT 421
proteasome 419
ara 418
mTOR 417
TNF 416
G-CSF 412
mast cell 408
bcr 402
CD5 399
caspase-9 398
histone deacetylase 394
CD13 392
DBA 389
Pol 387
Gag 385
T cell receptor 383
JAK2 379
CD11b 378
TCR 376
cyclin D1 373
IL-4 371
Gen 369
endoplasmic reticulum 369
major histocompatibility complex 364
CD7 364
p38 362
p15 362
CD45 361
erythropoietin 360
Mcl-1 360
peroxidase 359
NOD 358
granulocyte-macrophage 358
CD25 358
BCR/ABL 354
MDS 346
bcl-2 344
IFN-gamma 342
human leukocyte antigen 342
annexin V 341
envelope protein 334
p30 333
IgG3 333
megakaryocyte 327
MHC 325
STAT 319
c-Myc 318
envelope glycoprotein 317
CD14 314
lipopolysaccharide 312
CD2 312
STAT3 311
MYC 310
chimeric protein 308
AF9 306
histone H3 301
c-kit 298
L-asparaginase 297
phosphatase 296
telomeric 295
p27 292
ape 287
Raji 286
interleukin-6 285
FISH 285
BCL2 284
macrophage colony-stimulating factor 282
osteosarcoma 280
WT1 277
STAT5 276
alkaline phosphatase 275
ubiquitin 275
BCR-ABL1 273
bcr/abl 272
CXCR4 272
TSP 267
TNF-alpha 266
SCT 265
TdT 264
c-fms 257
p12 256
CR1 255
more...
Disease
leukemia 93477
cancer 24147
Leukemia 14593
acute myeloid leukemia 11747
tumor 11691
lymphoma 8891
acute lymphoblastic leukemia 7046
chronic myeloid leukemia 4580
acute leukemia 3317
myelodysplastic syndrome 3171
chronic lymphocytic leukemia 2933
graft-versus-host disease 2597
multiple myeloma 2469
leukemogenesis 2079
chronic lymphocytic leukemia 2012
immunodeficiency 1980
Hodgkin's disease 1913
breast cancer 1726
melanoma 1703
carcinoma 1620
sarcoma 1559
acute promyelocytic leukemia 1552
HIV 1462
anemia 1461
myeloid leukemia 1410
minimal residual disease 1358
non-Hodgkin's lymphoma 1250
hematologic malignancies 1232
lymphoblastic leukemia 1215
ABL 1162
tumorigenesis 1126
T-cell acute lymphoblastic leukemia 1027
CEM 1005
neutropenia 995
thrombocytopenia 974
B-cell lymphoma 946
lung cancer 944
myeloproliferative disorders 900
AIDS 872
tumor growth 870
childhood ALL 869
blast crisis 863
adult T-cell leukemia/lymphoma 804
aplastic anemia 753
Epstein 727
HTLV-I 714
virus infection 687
SCID 659
carcinogenesis 657
Down syndrome 656
infectious diseases 639
prostate cancer 633
adenocarcinoma 628
hepatocellular carcinoma 627
erythroleukemia 609
B-ALL 603
childhood cancer 596
lymphadenopathy 581
solid tumor 567
neuroblastoma 541
Burkitt's lymphoma 540
WT1 539
acute nonlymphocytic leukemia 531
cytomegalovirus 529
MCF 526
HAM 526
T-cell lymphoma 524
pancytopenia 519
sepsis 518
residual disease 513
PML 491
lung carcinoma 489
pneumonia 486
metastases 483
Infection 482
colon cancer 480
myelofibrosis 454
DBA 422
hairy cell leukemia 420
sepsis 410
myelopathy 408
tumor progression 407
diabetes 398
B-cell chronic lymphocytic leukemia 383
trisomy 378
lymphoproliferative disorders 378
fungal infection 371
myelosuppression 361
NOD 358
ovarian cancer 353
gastric cancer 353
stomatitis 348
MDS 346
lymphocytosis 340
osteosarcoma 340
chronic myelomonocytic leukemia 331
retinoblastoma 327
acute monocytic leukemia 311
rheumatoid arthritis 306
polycythemia vera 295
lymphosarcoma 291
SDS 289
herpes simplex 282
glioma 279
T-cell lymphomas 279
hypercalcemia 279
colorectal cancer 274
eosinophilia 272
SCT 265
ATM 264
depression 263
dysplasia 259
aspergillosis 253
follicular lymphoma 252
squamous cell carcinoma 249
refractory anemia 244
adult ALL 242
mantle cell lymphoma 237
thrombocytosis 236
disseminated intravascular coagulation 235
B-cell lymphomas 231
LGL leukemia 230
bovine leukemia 229
primary myelofibrosis 229
mammary tumor 229
GSH 225
hepatitis B 224
viremia 220
chloroma 220
influenza 216
glioblastoma 216
pancreatic cancer 215
essential thrombocythemia 214
PHA 213
interstitial pneumonia 213
Fanconi 212
trisomy 8 209
non-small cell lung cancer 209
secondary AML 203
plaque 201
Best 199
leukopenia 199
liver cancer 199
fibrosarcoma 197
myeloblastosis 191
bladder cancer 190
cervical cancer 189
West 186
renal cancer 186
hepatitis 184
liver cancer 183
pediatric AML 181
thyroid cancer 180
arthritis 180
systemic lupus erythematosus 179
agranulocytosis 177
Kaposi's sarcoma 174
adult AML 174
Rous sarcoma 172
NHL 172
more...
Symptom
splenomegaly 740
pain 326
hepatosplenomegaly 299
diarrhea 272
fatigue 222
vomiting 210
nausea 197
headache 165
hepatomegaly 151
anorexia 138
seizures 136
abdominal pain 124
nausea and vomiting 122
weakness 112
dyspnea 110
exhaustion 101
bone pain 97
starvation 92
collapse 88
lethargy 72
erythema 71
cough 67
respiratory distress 67
anesthesia 60
paraparesis 60
Ill 58
pallor 56
ataxia 53
cachexia 51
back pain 48
chills 43
discomfort 40
fever of unknown origin 37
sleepiness 35
discomfort 34
arthralgia 34
overweight 34
myalgia 33
hemoptysis 29
paresis 29
tremor 25
constipation 25
HSA 24
shortness of breath 23
dizziness 20
chest pain 20
paresthesia 19
epigastric pain 18
hypothermia 18
numbness 18
blurred vision 18
asthenia 18
polyuria 17
acute abdomen 17
cerebellar ataxia 16
vertigo 16
acidity 16
ENT 15
low back pain 15
abdominal discomfort 14
tachypnea 14
decreased appetite 12
spasticity 12
flushing 12
hemiplegia 11
thinning 11
chromosome marker 11
analgesia 11
night sweats 11
emaciation 11
functional recovery 11
polydipsia 10
colic 9
photophobia 9
hypoproteinemia 9
agitation 9
rigors 9
intestinal bleeding 9
hypotonia 9
ophthalmoplegia 9
dysarthria 8
insomnia 8
dry skin 8
hip pain 7
syncope 7
angina 7
sore throat 6
apathy 6
right lower quadrant pain 6
stigma 6
wheezing 6
oliguria 6
pleuritic chest pain 5
distraction 5
hoarseness 5
facial pain 5
consciousness disturbance 5
rhinorrhea 5
right upper quadrant pain 5
hyperoxia 4
acute abdominal pain 4
autodigestion 4
shoulder pain 4
chest tightness 4
memory loss 4
Fluctuation 4
prostration 4
Decreased activity 4
hypercapnia 4
tonic-clonic seizure 4
leg pain 4
dysuria 4
incoordination 4
productive cough 4
cancer pain 4
stomach pain 4
Roth spots 4
livedo 4
neuralgia 4
physical appearance 4
limb pain 4
skin irritation 4
sciatica 3
exertional dyspnea 3
labored breathing 3
abdominal fullness 3
Spastic paraparesis 3
clubbing 3
stridor 3
redness of the eyes 3
adenitis 3
hyperesthesia 3
urinary frequency 3
generalized rash 3
Catch 3
meningism 3
dry eye 3
Spotting 3
myoclonus 3
nasal congestion 3
non-productive cough 3
neck pain 3
left upper quadrant pain 3
pelvic pain 3
jaw pain 2
periorbital edema 2
ACHE 2
feeling nervous 2
sneezing 2
lassitude 2
forgetfulness 2
Depressive symptoms 2
eye pain 2
tinnitus 2
neurological disability 2
dental pain 2
tingling 2
drooling 2
Scratch 2
hyperemesis 2
more...
Drug
CSF 884
IL-2 705
lysine 594
G-CSF 421
Dermatol 415
MDS 346
IFN-gamma 333
Imatinib 314
TEL 289
Adriamycin 218
ROS 199
ADR 185
Gleevec 170
Leaf 166
CTX 154
Arsenic trioxide 148
G418 118
-deoxyadenosine 109
ETS 105
MRC 102
Retinoic acid 93
VCR 92
DNase I 91
Campath 89
Campath 89
Etoposide 86
VCR 86
ascorbate 85
ADM 82
AraC 81
Fludarabine 80
anti-CD33 78
Bortezomib 75
Rituximab 73
IL-11 72
NBT 71
Dasatinib 70
Gel 70
AZT 69
AZT 69
Meth 62
p75 59
THF 57
MAP 57
Mutagen 56
ARA-C 54
ABC 54
Idarubicin 53
vitamin E 52
caffeine 48
Asparaginase 46
Taxol 45
Asn 45
Monit 43
Sorafenib 40
Clofarabine 40
Cardiovasc 37
NADH 37
L-Asparaginase 36
TRM 36
CPT-11 32
lactose 32
CTX 30
CTX 30
IFN-beta 30
Histamine 28
Indomethacin 27
EPA 27
Glutathione 27
ENT 26
Prednisolone 26
ROC 24
Itraconazole 24
Lenalidomide 23
NH3 22
TAT 22
Norplant 21
Alliance 21
PTH 21
Adenosine deaminase 20
NVP 20
ampicillin 20
Filgrastim 20
TAK 19
Hypaque 19
Docetaxel 19
TTC 19
AmBisome 19
Lovastatin 19
Hypaque 19
CAM 19
Fluorescein 18
Heme 18
Fluconazole 18
Growth hormone 17
Retinoic Acid 17
CDP 17
EE2 17
Growth hormone 17
Fluorescein 16
uPA 16
Vinorelbine 16
Prednisone 16
CTC 15
Alanine 15
Asthma 15
Flavopiridol 15
PMEA 15
Bestatin 15
Filgrastim 15
Vitamin A 15
TAC 14
Amifostine 14
Isotretinoin 14
CCL 14
Fraction 14
CTC 14
Paraffin 14
Taxotere 14
Novantrone 13
Gefitinib 13
GEO 13
ACT 12
Tacrolimus 12
Ethanol 12
Biopolymers 12
Activin 12
Irinotecan 12
Acyclovir 12
CFS 12
Forskolin 12
Herceptin 11
Emodin 11
Vorinostat 11
Compound 9 11
Bosutinib 11
KCL 11
Emodin 11
Midostaurin 11
Tipifarnib 10
Azacytidine 10
Leucovorin 10
Dial 10
Photofrin 10
ZnCl2 10
L-tyrosine 10
ZnCl2 10
Daclizumab 10
Cremophor EL 9
nitroglycerin 9
Vitamin K2 9
CaCl2 9
PTC 9
CaCl2 9
Vitamin E 9
Spectrum 9
Nephron 9
CaCl2 9
ALA 9
Anagrelide 9
more...
Enzyme
focal adhesion kinase 2083
ERK 1874
reverse transcriptase 1251
mitogen-activated protein kinase 1224
caspase-3 1173
peroxidase 869
protein kinase 802
P-glycoprotein 699
topoisomerase 671
topoisomerase 607
protein kinase C 586
asparaginase 525
CD10 510
PARP 503
BMT 442
proteasome 427
CD13 394
MEK 356
RNA polymerase 347
caspase-8 346
caspase-9 342
luciferase 341
DNA polymerase 334
lactate dehydrogenase 292
alkaline phosphatase 280
dihydrofolate reductase 230
catalase 224
TdT 219
trypsin 217
lysozyme 203
thymidine kinase 189
phosphatidylinositol 3-kinase 185
acid phosphatase 180
endonuclease 179
RNase 179
RNase 172
hexosaminidase 172
cdc2 172
ATPase 171
superoxide dismutase 170
RNase H 167
transcriptase 164
glutathione S-transferase 162
phospholipase C 149
thymidylate synthase 148
adenosine deaminase 146
adenosine deaminase 144
calcineurin 144
DNA methyltransferase 144
beta-galactosidase 141
MDR 134
Rex 131
neuraminidase 123
granzyme B 114
ribonucleotide reductase 113
thrombin 112
phosphoinositide 3-kinase 112
ribonucleotide reductase 109
ricin 107
IKK 100
chloramphenicol acetyltransferase 100
ACS 93
APC 89
deoxycytidine kinase 89
alanine aminotransferase 81
ornithine decarboxylase 81
glutathione peroxidase 76
IMP dehydrogenase 75
demethylase 73
carboxylesterase 72
caspase-1 70
histone acetyltransferase 70
AMP-activated protein kinase 70
phospholipase A2 69
DNase 68
urokinase-type plasminogen activator 66
AMPK 66
acetylcholinesterase 63
GSK 60
NADPH oxidase 58
NQO1 58
aldehyde dehydrogenase 56
ribonuclease 54
ribonuclease 54
plasmin 54
neutrophil elastase 53
protein phosphatase 2A 52
NADPH oxidase 52
lipoxygenase 52
cytidine deaminase 51
hypoxanthine-guanine phosphoribosyltransferase 51
deaminase 50
aldehyde dehydrogenase 47
adenylate cyclase 47
asparagine synthetase 46
folylpolyglutamate synthetase 46
thiopurine methyltransferase 45
purine nucleoside phosphorylase 45
thromboplastin 44
chymotrypsin 44
phosphodiesterase 44
phosphoglycerate kinase 44
aspartate aminotransferase 42
tryptase 42
aldehyde dehydrogenase 41
aldehyde dehydrogenase 41
aldehyde dehydrogenase 41
MIP 41
MAP 41
5'-nucleotidase 40
collagenase 40
glyceraldehyde-3-phosphate dehydrogenase 40
glutaminase 40
glucose-6-phosphate dehydrogenase 39
AMPK 39
S1 nuclease 39
elastase 38
papain 38
NOS 36
isocitrate dehydrogenase 35
RNase T1 34
cathepsin G 34
glutathione reductase 34
isocitrate dehydrogenase 34
tyrosinase 33
beta-glucuronidase 33
complex I 33
farnesyltransferase 32
farnesyltransferase 31
caspase-2 31
tissue plasminogen activator 31
gamma-glutamyl transpeptidase 30
p100 30
MMP 29
caspase-2 29
DNA ligase 28
DNA ligase 28
TSA 28
thyroid peroxidase 27
HIV-1 protease 27
hyaluronidase 27
cathepsin B 27
histone demethylase 27
S-adenosylmethionine decarboxylase 27
glyceraldehyde-3-phosphate dehydrogenase 26
phospholipase D 25
creatine kinase 25
myosin light chain kinase 25
caspase-7 24
proteinase-3 24
caspase-7 24
STR 23
glyceraldehyde-3-phosphate dehydrogenase 23
xanthine oxidase 23
NO synthase 22
cholinesterase 22
PDK1 22
lipoprotein lipase 22
pepsin 22
histidine decarboxylase 22
more...
Compound
DNA 10754
Dec 6565
Clin 3913
retinoic acid 1438
oxygen 1363
tyrosine 1256
calcium 1244
BCR 1227
ABL 1163
acetate 1118
MTT 785
water 762
sodium 758
lysine 712
THP 608
THP 604
ATP 554
phosphate 525
Ara-C 524
serine 504
benzene 488
leucine 449
cysteine 434
Ara-C 421
TNF 416
DBA 415
glucose 398
DBA 386
arginine 386
DBA 386
sulfate 373
tryptophan 369
iron 362
iodine 346
His 346
nitrogen 344
zinc 338
threonine 334
Methotrexate 329
methionine 324
hydrogen 318
bromide 317
Adriamycin 315
VP-16 300
TEL 289
ADR 280
pyrimidine 279
pyrimidine 278
MDA 273
alanine 273
SDS 253
MEK 248
GSH 243
GSH 243
galactose 243
AMP 231
cAMP 230
Asp 225
GTP 220
Phe 214
urea 211
ethanol 201
salt 193
DMSO 190
PEG 189
boron 185
NH2 183
methanol 181
uridine 181
ADP 176
TBI 175
MTX 173
nitric oxide 170
copper 170
PMA 170
TPA 164
PMA 163
TPA 162
acridine 161
creatinine 159
glutamine 157
CTX 154
asparagine 152
ADP 151
ADP 151
proline 149
potassium 147
vitamin D 142
formaldehyde 141
N-acetylcysteine 141
PEG 139
DDP 139
Benzene 139
MDR 134
Pac 125
Gly 124
pyridine 123
glutamate 123
BCNU 120
formaldehyde 120
CTP 120
H2O2 117
DEAE 112
ADP-ribose 110
SET 101
tryptophan 101
NFS 100
Cyclosporine 100
tryptophan 99
tryptophan 99
COS 97
ammonium 97
Ile 95
ACS 95
silver 94
ACS 93
manganese 93
hydroquinone 92
Optimal 91
BCG 90
phenol 89
LTC4 88
NAD 88
Curcumin 87
aldehyde 86
Mg2+ 86
m-AMSA 86
anthracene 86
CAT 85
CAT 85
CAT 85
glutamic acid 84
5-FU 83
Histone 83
PAS 83
selenium 81
quinoline 81
quinoline 81
aldehyde 80
ATF 80
aspartic acid 78
DIC 78
NAD 78
nicotinamide 78
Daunorubicin 78
ethyl acetate 76
AZT 75
glycerol 74
HCl 74
DNP 73
dUTP 72
EDTA 72
NBT 72
TEM 71
MTS 71
Mitoxantrone 71
chloroform 71
phosphorus 70
Mitoxantrone 70
EDTA 69
more...