Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 34 patients (16 women and 18 men) with acute leukaemias (8 with acute lymphoblastic leukaemia and 26 with acute myeloblastic leukaemia), as yet untreated, the serum levels were determined of conjugated cholic acid, bilirubin, aspartate aminotransferase (AspAT), alanine aminotransferase (AlAT), alkaline phosphatase (AP), lactate dehydrogenase (LDH) and cholinesterase (Chol). Serum conjugated cholic acid level was determined by radioimmunoassay. The mean values of AP and Chol activity were within the range of normal values in this laboratory, the values of AspAT and AlAT were slightly above this range, and LDH value exceeded twice this normal range. The mean bilirubin concentration was within normal range. The greatest changes were noted in conjugated cholic acid values, the mean value exceeded five times the upper normal range (1.0 mumol/l). In 30 patients (88%) the conjugated cholic acid level in the serum was above 1.0 mumol/l, in the remaining 4 cases it was above the mean value for the control group. No correlation was found between conjugated cholic acid and any of the determined parameters. These results point out that the serum level of conjugated cholic acid may be a valuable parameter for assessment of hepatocellular function in acute leukaemias.
Pol Arch Med Wewn
PMID:[Serum cholic acid levels in patients with acute leukemia]. 225 Dec 7

In 91 patients with acute non-lymphoblastic leukaemia the peroxidase index was determined in blast cells or promyelocytes in bone marrow. Complete remission was obtained exclusively in patients with the value of the index 0-9% or over 69%. The duration of the remission and the survival time were significantly longer in patients with a high peroxidase index. This index may be useful for prediction of the course of acute non-lymphoblastic leukaemia in adults and its high value is associated with better prognosis.
Acta Haematol Pol
PMID:[Prognostic value of the peroxidase index in patients with acute nonlymphoblastic leukemia]. 226 Apr 7

The spleen was irradiated in 8 patients with chronic lymphatic leukaemia using RTG radiation in doses of 225 to 800 cGy for one treatment course. The follow-up after radiotherapy lasted 12.5 months on average. In 7 cases a considerable reduction was observed in the size of the spleen, and in 6 cases the absolute leucocyte and lymphocyte counts decreased by a mean of 46% and 50% respectively. In patients in late phase of the disease the improvement was short-lasting; 5 patients died (2 from infectious complications). In patients in early phase remissions of 30 months were obtained with normalization of the proportions or T and B cells During the radiotherapy a significant rise was observed in the per cent of granulocytes and a fall of albumin level. Increased gamma-globulin and uric acid levels and decreased hemoglobin level and erythrocyte count were not significant. Variable changes were noted in the platelet count. No bleeding tendency was noted. Spleen irradiation may be used in the treatment of non-Hodgkin lymphoma associated with malignant proliferation prevailing in the spleen, that is in chronic prolymphocytic leukaemia and hairy-cell leukaemia Favourable effects of spleen irradiation were observed in chronic lymphatic leukaemia and this induced us to use this method in our eight cases.
Acta Haematol Pol
PMID:[Treatment of low-malignancy lymphomas by spleen irradiation]. 226 Apr 12

A case is presented of a rare T-phenotype acute lymphoblastic leukaemia. The blast cells were negative in the rosette test and demonstrated expression of the Ia antigen.
Acta Haematol Pol
PMID:[T-cell acute lymphoblastic leukemia E(-) with antigen Ia expression]. 226 Apr 13

The analysis was based on 31 patients with chronic granulocytic leukaemia (CGL) treated during the period 1975-1986 and the correlation between the total dose of busulphan administered during the first year of treatment and the duration of chronic phase of the disease was investigated. We found such correlation and also we found that the duration of the chronic phase was more significantly correlated with one year maintenance dose of busulphan. This suggests that the prognosis in CGL is more connected with the proliferation activity of leukaemic cells than with the extent of disease at the time of diagnosis.
Acta Haematol Pol
PMID:[Relation between the duration of the chronic phase of chronic myeloid leukemia and total dose of busulfan in the first year of the treatment]. 226 Apr 9

The nucleotide sequence of the human spumaretrovirus (HSRV) genome was determined. The 5' long terminal repeat region was analyzed by strong stop cDNA synthesis and S1 nuclease mapping. The length of the RU5 region was determined and found to be 346 nucleotides long. The 5' long terminal repeat is 1,123 base pairs long and is bound by an 18-base-pair primer-binding site complementary to the 3' end of mammalian lysine-1,2-specific tRNA. Open reading frames for gag and pol genes were identified. Surprisingly, the HSRV gag protein does not contain the cysteine motif of the nucleic acid-binding proteins found in and typical of all other retroviral gag proteins; instead the HSRV gag gene encodes a strongly basic protein reminiscent of those of hepatitis B virus and retrotransposons. The carboxy-terminal part of the HSRV gag gene products encodes a protease domain. The pol gene overlaps the gag gene and is postulated to be synthesized as a gag/pol precursor via translational frameshifting analogous to that of Rous sarcoma virus, with 7 nucleotides immediately upstream of the termination codons of gag conserved between the two viral genomes. The HSRV pol gene is 2,730 nucleotides long, and its deduced protein sequence is readily subdivided into three well-conserved domains, the reverse transcriptase, the RNase H, and the integrase. Although the degree of homology of the HSRV reverse transcriptase domain is highest to that of murine leukemia virus, the HSRV genomic organization is more similar to that of human and simian immunodeficiency viruses. The data justify classifying the spumaretroviruses as a third subfamily of Retroviridae.
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PMID:Analysis of the primary structure of the long terminal repeat and the gag and pol genes of the human spumaretrovirus. 245 55

Five patients, cured from acute lymphoblastic leukaemia (ALL), four women and one man, have seven healthy children: four girls and three boys. The children were born in the period from 13 to 25 years since the beginning of the disease and 5 to 16 years after cessation of monotherapy. Age of the children varied from 2 to 13 years. In two patients and in their children an inversion or a partial inversion of the heterochromatic region of chromosome 9 was observed.
Mater Med Pol
PMID:The possibility of a healthy progeny in patients after acute lymphoblastic leukaemia. 248 63

In 21 patients with haemophilia, 10 with acute leukaemia, 12 with malignant lymphomas, and 12 with multiple myeloma in whom the risk of viral infection is increased the following antibodies were determined: anti- CMV, anti-HIV, anti-HBs, and HBs antigen by ELISA test. Anti-CMV were found mainly in acute leukaemia (90%), in haemophilia (71.4%), in malignant lymphoma (41.7%) and multiple myeloma (33.3%). In 19% of cases of haemophilia anti-HIV antibodies were present. In other groups these antibodies were not found. In acute leukaemias mostly anti-HBs antibodies were present. The group of haemophiliacs is particularly exposed to infection by these viruses which is connected unquestionably to blood transfusions.
Acta Haematol Pol
PMID:[Anti-HBS, anti-CMV, and anti-HIV antibodies and HBS antigen in patients with hemophilia, malignant lymphomas, leukemias and multiple myeloma]. 256 46

The activity of adenosine deaminase was determined in the cerebrospinal fluid in children with acute lymphoblastic leukaemia in various phases. It was found that an evident rise of this activity occurred during leukaemic meningeal involvement as compared with the initial phase the disease or with the first complete remission. After an episode of recurrent cerebrospinal leukaemia the activity of the enzyme was also higher than during the first complete remission. Such high values as during meningeal leukaemia were not found in inflammatory cerebrospinal fluid which suggests that determinations of this enzyme could be useful for differentiation of leukaemic infiltrations in the central nervous system against lymphocytic meningitis.
Acta Haematol Pol
PMID:[Adenosine deaminase activity in the cerebrospinal fluid of children with acute lymphoblastic leukemia]. 263 33

Comparison of the level of anxiety with advice in threatening situations was studied in the leukaemia patients. The tests involved 60 patients (32 man, 28 woman), mean age 42 years. Anxiety level was established with the aid of a 10-grade scale of self-score of anxiety--Self Cognition by Cattell--and self-concept by ACL Gough's (Adjective Check List). Analysis of the results have shown, that the highest level of anxiety leads to disintegration self-concept, while repression technique of anxiety reduction leads to compensation self-concept. Both play a role in adaptation process. Psychotherapy of such patients aim at decreasing the level of anxiety and neutralization to negative changes in self-concept of the patients.
Pol Tyg Lek 1989 May 15
PMID:[Methods of defense against anxiety and self concept of patients with leukemia]. 264 Jul 7


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