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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The author discusses the occurrence of disseminated intravascular clotting syndrome in patients with acute leukaemias in the light of personal material comprising 9 cases. The syndrome may appear as a complication of the main disease or of chemotherapy applied in it. It is most frequent in acute promyelocytic leukaemia and this fact may suggest that promyelocytes play a role in initiation of blood clotting. The problem of diagnosis and treatment of this syndrome in patients with acute leukaemia is discussed.
Acta Haematol Pol 1976
PMID:[Intravascular disseminated coagulation syndrome in patients with acute leukemias]. 106 78

The author describes a 20-year-old patient with leukaemia and with meningoradicular symptoms. The first neurological symptoms developed 2 years after disclosure of haematological changes. Despite treatment with steroids, intrathecal Methotrexate and radiotherapy the patient died 3 years after the diagnosis of leukaemia had been established. Myeloblastic leukaemia was confirmed on autopsy. The importance of early intrathecal Methotrexate treatment is stressed.
Neurol Neurochir Pol
PMID:[Diagnostic difficulties in a case of leukemia with radicular symptoms]. 106 49

Adrenal function was studied in patients with chronic myeloid leukaemia treated in the past or presently with Busulphan. Adrenocortical function was determined by means of 24-hour profile of 11-hydroxysteroids (11-OHCS) in plasma, and urinary 24-hour 17 hydrocorticosteroids (17-OHCS) and 17-ketosteroids (17-KS). The adrenomedullary function was determined measuring VMA level in 24-hour urine. In most patients normal 24-hour 11-OHCS profiles and 24-levels of 17-OHCS, 17-KS and VMA. Only in some cases these levels were raised. This rise was observed more frequently in patients with blastic crisis of myeloid leukaemia which may indicate that the adrenal reserve was maintained in these patients. The investigations failed to show that the disease itself or Busulphan treatment impaired adrenal function. The possibility of a direct effect of Busulphan on melanin metabolism in the organism is discussed.
Acta Haematol Pol
PMID:[Adrenal function in chronic myeloid leukemia]. 106 55

Investigations were carried out on 261 patients with chronic lymphatic leukaemia with survival over 4 years. The following problems were discussed: age and sex of patients, presenting symptoms, organ changes, laboratory investigations, infectious complications, coexistence of malignant tumours. Correlations were established between various parameters and the length of survival. It was demonstrated that patients without palpable lymph nodes and spleen at the beginning of the diseases and with leucocyte counts ranging from 10,000 to 100,000/1 mm-3 have a better prognosis, while thrombocytopenia even without haemorrhagic diathesis is a poor prognostic sign. Infections were observed in 50 percent of cases, more frequently in patients with hypogammaglobulinaemia. Coexistence of malignant tumours was found in 5.4 percent of cases. Pathological examinations including organ biopsy and autopsy failed to demonstrate characteristic features of lymphatic system proliferation as compared with patients with short survival.
Acta Haematol Pol
PMID:[Clinical and pathological analysis of patients with chronic lymphatic leukemia and long survival]. 112 36

The authors analysed 202 cases of chronic lymphatic leukaemia comparing the course of this disease in patients above and below 60 years of age. The observation included patients with various forms of this disease--with morphological and clinical findings compatible with mild disease and cases with severe course with complications. It was observed that in severe form of lymphatic leukaemia the course of the disease is similar in both groups of patients and the shorter survival of patients in the older group is frequently due to coexistence of other diseases impairing the general condition and changes connected age. On the other hand, a mild, oligosymptomatic course of the disease was observed more frequently in older patients who did not require intense treatment in hospitals.
Acta Haematol Pol
PMID:[Course of chronic lymphatic leukemia in 2 age groups: older and younger patients]. 112 37

The authors describe mitotic activity in non-stimulated cultures of mononuclear cells obtained from the peripheral blood of patients with lymphosarcoma. The investigations were carried out on 3 patients in stage 3rd and 4th of this disease and 5 patients in the stage of sarcomatous-cell leukaemia. During a period of 24-48 hours after setting up of culture a rise was observed in the number of blast cells and appearance of up to 10% of mitotic figures. This observation may be useful for differentiation of sarcomatous-cell leukaemia from chronic lymphocytic leukaemia in which cells obtained from the peripheral blood and cultured in vitro without addition of mitogen do not demonstrate mitotic activity.
Acta Haematol Pol
PMID:[Value of determination of mononuclear blood cell proliferation in vitro in the diagnosis of lymphosarcoma]. 117 77

Adult BDF1 and DBA/2J mice were inoculated i.p. with "L-1210" leukemia cells and then received i.p. control or immune sera raised in C27B1/6 and BALB/c mice. Undiluted sera were administered in single or multiple doses ranging from 0.2 to 0.4 ml/mouse on day 0., resp. 0., 2-4, and 7. In BDF1 hybrids permanent survivals (greater than 150 days) and distinct prolongation of the mean survival time (MST) after multiple injections were observed. However, normal serum derived from non-immunized C57B1/6 donors was also demonstrated to provide protection when injected three times. In DBA/2J recipients no permanent survivals were observed. In this mouse strain control sera proved ineffective. On the contrary, immune sera enabled the recipients to survive longer and this prolongation proved to be statistically significant (p less than 0.02). Partial natural immunity against "L-1210" leukemia in BDF1 hybrids must be, therefore, postulated. It is probably due to H-2-locus incompatibility versus "L-1210" cells, inherited from the C57B1/6 ancetor-line. Unknown factors which are present in normal serum seem to potientiate this natural resistance. In compatible DBA/2J mice normal serum constituents were ineffective, on the other hand, however, the effectiveness of specific immune factors directed against target cells of the tumor could be demonstrated in them
Pol Med Sci Hist Bull
PMID:Multiple immune serum injections in prevention of murine "L-1210" leukemia growth. 122 9

Using the fluorescence technique the presence of various immunoglobulin classes (IgG, IgA, IgM) was determined on the surface of peripheral blood lymphocytes obtained from healthy subjects (10 cases) and from patients with chronic lymphatic leukaemia (65 cases). In the investigations the effect of treatment and clinical course on the values of these parameters was taken into consideration. Nearly in all cases of this leukaemia the percent of lymphocytes binding immunoglobulins on their surface was raised in comparison with the lymphocytes of healthy subjects. Presence of one or more classes of immunoglobulins was demonstrated on the surface of leukaemic lymphocytes.
Acta Haematol Pol 1976
PMID:[Surface immunoglobulins of lymphocytes in chronic lymphocytic leukemia]. 125 73

Seven cases of leukaemic form of lymphosarcoma are presented. In all studied patients three characteristic signs were present: generalized lymphadenopathy, presence of lymphosarcoma cells in peripheral blood, spontaneous proliferation of white blood cells in short-term culture. Differential diagnostic difficulties with regard to chronic lymphatic leukaemia are stressed. It is thought that the sign of spontaneous proliferation may be used as a differential diagnostic criterion.
Acta Haematol Pol 1976
PMID:[Leukemic form of lymphosarcoma (clinical study of 7 cases]. 125 76

The author describes a case of hypophyseal tumor coexisting with chronic leukaemia. It is suggested that both these processes coexisted from the very beginning of the disease. Development of hypothalmo-hypophyseal system failure was due to the presence of hypophyseal tumour while intensification of these manifestations in the last stage of the disease was caused by the presence of leukaemic changes in the central nervous system.
Neurol Neurochir Pol
PMID:[Chronic leukemia coexisting with hypophyseal tumor]. 125 25


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