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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 57 children in remissions of acute lymphoblastic leukaemia 217 determinations of serum iron (Fe) and copper (Cu) levels were done. In 85% of cases serum Fe and Cu were determined simultaneously with bone marrow examination. Raised mean Cu level in complete remission (20.64 mumol/1) decreased with continuing remission to values observed in healthy children (18.40 mumol/1). The considerable rise in Cu serum level in cases with extramedullary location of the disease (26.04 mumol/1), in infections complicating remissions (23.32 mumol/1) and in the group of children with remission in whom recurrence of leukaemia developed after 0,5-2 months (26,84 mumol/1) was associated with a significant fall of serum Fe level in cases with organ location of the disease (12.82 mumol/1) and during bacterial and viral infections (12.67 mumol/1). The Fe/Cu index was highest in the group with remission extending over 3 years (0,89) and it was significantly low in the group with extramedullary location of the disease (0.45) and in infections during leukaemia remission (0.48). Determination of serum level of Fe, and even more of Cu was found to be useful in the management of children during remission of acute lymphoblastic leukaemia.
Acta Haematol Pol
PMID:[Iron, copper and iron/copper index in the serum during remission of acute leukemia in children]. 28 Oct 85

In 22 patients with acute myeloid leukaemia (17 cases of myeloblastic leukaemia, 4 cases of myelomonocytic leukaemia and 1 case of undifferentiated-cell leukaemia) platelets were isolated from the plasma by the method of Nicholls and Hampton as modified by Levy-Toledano by centrifugation in albumin gradient. The aim of platelet isolation was their "concentration" in cases of thrombocytopenia to values making possible aggregation tests, and platelet separation from the influence of plasma factors. Then aggregation of isolated platelets caused by ADP was studied. In 16 out of 22 patients a fall of aggregation was observed, with the mean values of aggregation rate and intensity were significantly lower. Parallelly done determinations of aggregating activity released from the platelets by thrombin showed lower values as compared with platelets from healthy subjects. In might be thought, in this connection, that the demonstrated reduction of isolated platelets is associated with a diminution of the nucleotide pool or disturbances of the platelet release reaction. The disturbances of the platelet release reaction. The disturbances of aggregation of isolated platelets and reduction of the aggregating activity were most pronounced in acute myelomonocytic leukaemia.
Acta Haematol Pol
PMID:[Platelet function in acute myeloid leukemia. II. Aggregation of isolated platelets]. 28 Oct 86

In 31 cases of acute leukaemia in adults the ability of leukaemic cells to phagocytize latex was investigated. This ability was confirmed in nearly all cases of monocytic and myelomonocytic leukaemia, in over 1/3 of cases of myeloblastic leukaemia and in one out of 9 cases of lymphoblastic leukaemia.
Acta Haematol Pol
PMID:[Phagocytic ability of blast cells in acute leukemia]. 28 62

A patient with Hodgkin's disease is reported in whom 5 years after establishing of diagnosis acute myeloid leukaemia developed during multistage treatment. The patient died. The authors discuss the problem of leukaemia-inducing influence of intensive radiotherapy and chemotherapy.
Acta Haematol Pol
PMID:[Acute myeloid leukemia during Hodgkin's disease]. 28 73

In 22 children with lymphoblastic leukaemia peripheral blood lymphocytes were studied during 2.5 years of remission-maintaining treatment, and in 7 cases also after stopping treatment. Lymphocytes T and B were identified and lymphocyte surface receptors for complement and for the Fc fragment of IgF were determined. The immunological reactivity of lymphocytes was determined also using the test of PHA-induced blastic transformation. It was found that prolonged chemotherapy caused depression of lymphocytes B in the first place. A fall was observed also in the proportion of cells undergoing transformation. It was shown that after cessation of treatment PHA-reactivity and normal values of lymphocyte subpopulations returned.
Acta Haematol Pol
PMID:[Immunological characteristics of lymphocytes during intensive treatment maintaining remission of acute lymphoblastic leukemia in children and following withdrawal from chemotherapy]. 28 75

The metabolism of 14C-lysine by leukaemic cells in acute myeloblastic, myelomonocytic, lymphoblastic and chronic myeloid leukaemia with blast crisis was studied. The investigations included lysine metabolism to CO2, lipids, organic acids and nucleotides and its incorporation into cellular proteins. The obtained results were compared with determinations carried out in granulocytes and lymphocytes of healthy subjects. Cells in acute leukaemias metabolized 14C-lysine in a similar range. In relation to normal cells the range of lysine metabolism to lipids in the leukaemic cells was significantly higher (p less than 0.01), while that of organic acids was significantly lower (p less than 0.05). The activity of 14C-lysine metabolism depended on the number of blast cells in the sample and the type of acute leukaemia. Neoplastic cells in blast crisis and in acute myeloblastic leukaemia incorporated more actively 14C-lysine into proteins than cells in acute myelomonocytic and acute lymphoblastic leukaemia (p less than 0.05). Similar differences in lysine metabolism were observed between myelomonocytes and blast cells from acute lymphoblastic leukaemia (p less than 0.05).
Acta Haematol Pol 1979 Oct
PMID:[Lysine metabolism in acute leukemia]. 29 72

A case of hairy-cell leukaemia was observed in a man aged 40 years. The diagnosis was based on the whole of clinical investigations and laboratory investigations, especially cytoenzymatic examination of leukaemic cells and examination of their structure in electron microscope. In treatment radiotherapy was appleid initially followed by splenectomy.
Acta Haematol Pol
PMID:[Hairy cell leukemia in the light of an observed case]. 30 78

The authors describe a rare case of Richter's syndrome (transition of chronic lymphatic leukaemia into reticulosarcoma) developing during rheumatoid arthritis in a women aged 53 years. Chronic antigenic stimulation and disturbances of interaction between lymphocytes T and B are suggested as a cause of Richter's syndrome.
Acta Haematol Pol
PMID:[Richter's syndrome and cervical cancer in the course of a rheumatoid arthritis]. 33 67

The authors report a trial of a comprehensive study of a correlations between various data obtained during history taking and the development of leukaemia in children. On the basis of epidemiological cards data were analysed concerning 200 children with acute leukaemia, including 108 boys and 92 girls. The control group comprised 217 healthy children. The method of classification of independent characteristics was used for the analysis of discernibility of children in these two groups. Continuous (or quantitative) characteristics were regarded as normally distributed, and discrete ones were defined by the frequencies found. As a result of computer processing of data 181 out of 200 patients (90.5%) and 204 controls (94.0%) were classified accurately. The mean error of classification was 7.75%.
Acta Haematol Pol
PMID:[Analysis of anamnestic data in patients with acute leukemia]. 37 63

Acute abdomen syndrome was the presenting sign of leukaemia in the reported case. The authors discuss indications to surgical treatment in patients with leukaemia.
Acta Haematol Pol 1979 Oct
PMID:[Pericecal abscess and infiltration as a complication in the early phase of acute non-differentiated cell leukemia]. 39 5


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