Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The activity of arylsulphatase A and B was determined in peripheral blood lymphoblasts in 23 children with acute lymphoblastic leukaemia before starting treatment. A low level of activity was found in the group of leukaemic children with poor prognosis, while in children with better prognostic indices this reactivity was high. The course of changes in this activity was traced also during induction of remission of leukaemia and during 3-year maintenance treatment.
Acta Haematol Pol
PMID:[Arylsulfatase A and B activity in acute lymphoblastic leukemia in children]. 3 70

A nonconditional mutant of B-tropic murine leukemia virus (MuLV), defective in polymerase, has been isolated by cloning chronically infected cells. The cell clone containing the mutant produced virus particles which were noninfectious. However, superinfection of the cells by replication-competent XC-negative viruses resulted in the rescue of virus capable of forming plaques in a modified XC test, termed the "complementation plaque assay" (A. Rein and R. H. Bassin, J. Virol. 28:656-660, 1978). Analysis of the noninfectious virions produced without superinfection demonstrated that they contained only 2 to 5% of the wild-type level of reverse transcriptase activity. Purification of this activity indicated that it was associated with a smaller molecule than that produced by wild-type virus. Cells producing the mutant virions did not contain the gag-pol precursor, Pr180gag-pol; however the cells contained proteins of 147K and 114K daltons precipitable with anti-pol serum. All of the normal structural proteins as well as 70S genomic RNA could be detected in the mutant particles. An interference test indicated that a functional ecotropic glycoprotein was synthesized by the mutant. These results indicate that the mutant has a unique defect in the pol gene.
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PMID:Mutant of B-tropic murine leukemia virus synthesizing an altered polymerase molecule. 9 71

The authors report beneficial effects of thiotepa on leukaemic involvement of the central nervous system. The drug was given to 4 children with central nervous system leukaemia refractory to methotrexate and cytarabine. Intrathecal thiotepa caused regression of changes in the cerebrospinal fluid and in the neurological status of these children. No side effects were observed during this treatment.
Acta Haematol Pol
PMID:[Thiotepa in the treatment of central nervous system leukemia in children]. 10 21

The level of cAMP was determined in isolated cells from bone marrow and peripheral blood of healthy subjects and patients with proliferative syndrome (acute and chronic myeloid leukaemia and chronic lymphatic leukaemia). In the investigations tritiated cAMP (3H-cAMP) was used and for binding of endogenous as well as exogenous cAMP protein isolated from bovine muscles was used. The mean cAMP level in peripheral blood granulocytes of healthy subjects was 27.90+/-3.82 pmol/10(7) cells and in normal lymphocytes it was from 11 to 18 pmol/10(7) cells. Much higher concentrations of cAMP: 56.4+/-16.25 and 52.7+/-11.02 pmol/10(7) cells were observed in myelocytes and metamyelocytes isolated from the bone marrow of healthy subjects. Lowering of cAMP concentration (below 4 pmol/10(7) cells) was observed in the lymphocytes of patients with chronic lymphatic leukaemia, while a higher cAMP concentration (above 90 pmol/10(7) cells) was found in the myeloblasts of patients with acute myeloid leukaemia.
Acta Haematol Pol
PMID:[Intracellular cAMP concentration in isolated cells of white blood cell series of peripheral blood and bone marrow in healthy subjects and patients with different proliferative syndromes]. 20 43

Using the method of ion-exchange chromatography in automatic analyser the level of free amino acids was determined in peripheral blood leucocytes of 14 healthy blood donors and 36 patients with various types of leukaemia. In comparison with granulocytes the concentration of free amino acids in lymphocytes was reduced. The concentration of free amino acids in lymphocytes of chronic lymphatic leukemia was not essentially changed. The leucocytes in chronic myeloid leukemia showed a rise in the concentration of most free amino acids. In the blast cells of patients with acute myeloid the concentration of free amino acids was reduced in relation to DNA contents while in relation to proteins this concentration was raised.
Acta Haematol Pol
PMID:[Free amino acids in leukemic leukocytes]. 26 61

In 29 patients with blood diseases, in 40 with other diseases and 22 healthy blood donors sucrose test for presence of plasma haemolytic factor was performed by the method of Hartmann et al. in the modification of Hansen. The percent index of haemolysis of erythrocytes after incubation with serum in 10% sucrose solution was calculated. The results were evaluated in 4 variants: 1) positive sucrose test for presence of SHF against own erythrocytes, 2) positive sucrose test for presence of SHF against foreign erythrocytes, 3) authohaemolysis in 10% sucrose and 0.9% NaCl solution, 4) haemolysis of foreign erythrocytes in 10% sucrose and 0.9% NaCl. The test was usually negative in healthy controls and patients with non-haematological diseases and in patients with leukemia it was positive in 17%.
Acta Haematol Pol
PMID:[Sucrose test in leukemias]. 26 62

The authors report two cases of acute leukaemia in adults with development of sings central nervous system involvement at the time of full haematological remission. In the first case the diagnosis was: acute undifferentiated-cell leukaemia, in the second one: acute lymphoblastic leukaemia. In both cases in the first stage of the disease complete remission of neurological manifestations was obtained; in the second case it was also obtained after the following relapse. In the first case death occurred during successive haematological exacerbation. Ametopterin was given intrathecally or X-ray therapy was applied.
Neurol Neurochir Pol 1977
PMID:[Leukemic meningeal involvement in adults and its treatment]. 26 11

The method of impulse cytophotometry was applied for determination of DNA content of blood cells in patients with various types of leukaemia. It was found that at the time of improvement in acute leukaemia the proportion of cells in the non-proliferative stage increases. In chronic leukaemias the improvement was associated with shifts in reverse direction.
Acta Haematol Pol
PMID:[Impulse-cytophotometric determination of DNA content in blood cells in patients with leukemia]. 26 33

In 40 patients with acute leukaemias the 3H-thymidine and mitosis indices were determined in the population of blast cells in bone marrow and the cellularity of bone marrow was determined. The studies were carried out in the first episode of the disease before treatment and in some patients (13) they were repeated during relapse after remission or improvement. The results showed that proliferative activity of blast cells was reduced in relation to precursors of normal granulopoiesis in all forms of acute leukaemia. Myeloblastic leukaemias showed a greater scater of values of both proliferation parameters in relation to lymphoblastic leukaemias. It was found, moreover, that in highly cellular bone marrow the proliferative activity of blast cell population was significantly lower than in patients with low bone marrow cellularity. On the ground of this observation the authors put forward the view that in acute leukaemias the intrinsic mechanism controlling the proliferation of cells is disturbed.
Acta Haematol Pol
PMID:[The mechanism of cell proliferation in acute (immature-cell) leukemia]. 27 Feb 71

The analysis was carried out on 31 children with acute lymphoblastic leukaemias. In 29 of them remissions were obtained conducting later during 3 years intensive maintenance therapy associated with radiotherapy to the central nervous system (according to the method of the Memphis group). Superiority of intensive treatment in relation to more sparing treatment has been demonstrated. Therapeutic failures were observed in children with primarily poor prognosis of leukaemia, especially with blastic hyperleucocytosis. The behavior of serum immunoglobulins and especially infections occurring in children during treatment are discussed.
Acta Haematol Pol
PMID:[Preliminary analysis of intensive treatment of acute lymphoblastic leukemia in children]. 27 42


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