Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Chronic lymphocytic leukemia (CLL) is the most frequent
leukemia
in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between
YPEL5
and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the
YPEL5
-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the
YPEL5
-PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.
...
PMID:The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples. 2660 51
