Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The expression of C-myc proto-oncogene were studied at the levels of protein in bone marrow cells obtained from patients with AML and CML. It was found that the expression of C-myc in florid AML and during blast phase of CML were much higher than that in remission of AML and in chronic phase of CML. In 7 cases of AML diagnosed for the first time, 2 cases with high C-myc expression had no remission after 3-6 months, while 5 with rare C-myc expression had remission after 3-6 months. This results suggest that the expression of C-myc proto-oncogene are possibly sensitive indicator of the prognosis of leukemia.
Zhonghua Nei Ke Za Zhi 1992 Mar
PMID:[The expression of C-myc oncogene in leukemia and its relationship to clinical symptoms]. 139 24

A clinicopathological study of leukemic kidney was carried out by observing the changes of the kidney in 104 autopsied cases of leukemia. The main changes of the leukemic kidney were increase of renal weight, calcinosis of renal tubules, interstitial leukemic cell infiltration, intravascular stasis and renal bleeding. Calcinosis intravascular stasis, renal bleeding as well as hyperuricemia may lead to abnormal urinary findings. The presence and severity of interstitial infiltration have no obvious relation with the level of blood urea nitrogen, creatinine and muric acid as well as the abnormal change of the urine. However, the presence of intravascular stasis by leukemic cells are correlated with the disturbance of renal function.
Zhonghua Nei Ke Za Zhi 1992 Mar
PMID:[A clinicopathological study of leukemic kidney]. 139 26

Ten leukemic patients were treated with allogeneic bone marrow transplantation (BMT). The diagnosis were ANLL in 6 cases, CML in 3 and ALL in one. Pretransplant immuno suppressive measures including total body irradiation cyclophosphamide and daunorubicin were given. All the patients were infused with health stem cell preparation, so that the hemopoietic function was restored. Graft versus-host disease of grade I to II was present in 5 of the patients. Leukemia recurred 76 days after BMT in one patient who received the procedure during a relapse of the disease, while in the remaining 9 patients disease-free survival from 1 to 23 months has been observed.
Zhonghua Nei Ke Za Zhi 1991 Jul
PMID:[Allogeneic bone marrow transplantation in the treatment of leukemia: analysis of 10 cases]. 168 16

Thirty four cases of isolated extramedullary relapse after complete remission of acute leukemia were reported. The relapse took place in central nervous system (CNS), genito-urinary system, skin, serous cavity, tonsils, lymph nodes, liver, spleen, gastro-intestinal tract, pancreas and ocular fundus. These 34 cases of isolated extramedullary relapse of leukemia was found in 206 cases with complete remission, constituting 16.5% of the total. In order to discover CNS relapse with no symptoms and signs, the author strongly suggest that cerebrospinal fluid examination be carried out periodically. If some symptoms signs in the patient can not explained by infection, congestion or other causes, extramedullary relapse should be considered and further examination and appropriate treatment are needed.
Zhonghua Nei Ke Za Zhi 1991 Mar
PMID:[Extramedullary relapse in acute leukemia]. 187 82

3 cases of leukemia after solid tumor and 2 cases of solid tumors after leukemia were reported. The features of leukemia after solid tumor and the relationship between the solid tumor and leukemia, as well as the possible pathogenetic factors of the secondary malignancies were discussed.
Zhonghua Nei Ke Za Zhi 1991 Apr
PMID:[Leukemia and solid tumor]. 187 91

Six cases of acute leukemia patients were treated with APHSCT and the clinical results were satisfactory. The preparatory marrow ablative chemoradiotherapy regimen before APHSCT was same as that for autologous bone marrow transplantation (ABMT). The number of mononuclear cells infused to restore the hematopoietic function ranged from 1.65 to 2.92 x 10(8)/kg and these cells yielded 0.17 to 2.26 x 10(4)/kg CFU-GM. The hematopoietic and immunological function of patients returned to normal level 25 to 38 days after APHSCT; the recovery was faster than that of ABMT and FLT. One patient each died of recurrence of leukemia and fungi septicemia 90 and 70 days after transplantation respectively, whereas the other four patients have survived for 9, 8, 4, and 2 months respectively.
Zhonghua Nei Ke Za Zhi 1990 Dec
PMID:[Autologous peripheral hematopoietic stem cell transplantation in leukemia]. 198 47

The immunophenotype of leukemicblasts from 111 patients with T-ALL or T-NHL were further examined by using a panel of standardized McAbs of CD nomenclature to human leukocyte differentiation antigens. Four major subsets of T-ALL were defined: pre T-ALL, immature T-ALL (I), common T-ALL (II) and mature T-ALL (III), with the percentages 20.7%, 20.7%, 20.7% and 37.0% respectively. In addition there was a case with M-T acute hybrid leukemia. Some of the clinical features of the patients with T-ALL and T-NHL were compared. It was found that male predominance, older age, higher leukocyte count, lower platelet level, relative higher hemoglobin level and increased incidence of extramedullary involvement, including hepatomegaly, splenomegaly and lymphadenopathy were alike for all subsets of T-ALL cases. However, the average white cell level and incidence of lymphadenopathy in the pre T-ALL subset significantly differed from those in other subsets. The correlation of immunophenotype with morphologic characterization was also discussed in this paper.
Zhonghua Nei Ke Za Zhi 1991 Jan
PMID:[Correlation of immunophenotype with clinical features in T-cell acute lymphoblastic leukemia]. 203 95

91 patients with acute nonlymphoblastic leukemia (ANLL) were treated with Homoharringtonine, Cytosine arabinnoside, Thioguanine (HAT) and/or Daunorubicin, (Adriamycin) Cytosine arabinnoside, Thioguanine D(A) AT protocols. The total CR rate was 68.1% with a median remission duration of 20.3 months, and the expectant survival rate in 5 years (Kaplan-Meier method) was 39%. The CR rate and the CR duration projected by HAT and D (A) AT protocols were very similar. After 20 prognostic factors from both clinical and laboratory examinations prior to treatment had been analysed, we concluded that (1) The CR rate was improved by increasing the dose of induction chemotherapy; (2) The patients might have longer remission and survival if they obtained remission in 2 courses of treatment; (3) The remission durations were comparable between the individuals receiving and not receiving maintenance chemotherapy.
Zhonghua Nei Ke Za Zhi 1990 Jan
PMID:[Analysis of the therapeutic efficacy and prognostic factors of intensive chemotherapy in 91 patients with acute nonlymphoblastic leukemia]. 240 Nov 66

Cerebrospinal fluid (CSF) beta 2-microglobulin (beta 2-MG) level was measured in 72 healthy subjects and the value (means +/- S means) was found to be 1.26 +/- 0.06 mg/L. The CSF beta 2-MG level in 33 patients who had simple acute leukemia without CNS involvement was 1.46 +/- 0.13 mg/L, which was not significantly different from that in the normal controls (P greater than 0.05). In 25 patients who had leukemia with involvement of CNS, the CSF beta 2-MG level (mean +/- S mean) was 3.94 +/- 0.30 mg/L, which was statistically different from that in the healthy controls (P less than 0.01). It is found that beta 2-MG level in CSF was one of the reliable criteria for diagnosis and indication of intrathecal chemotherapy in CNS leukemia.
Zhonghua Nei Ke Za Zhi 1989 May
PMID:[Clinical significance of cerebrospinal fluid beta 2-microglobulin determination in central nervous system leukemia]. 268 Mar 38

134 cases of central nervous system leukemia (CNSL) were reported. The clinical manifestations and the relationship of its occurrence with the duration of the disease and the effectiveness of prophylaxis were discussed. It was found that most cases of CNSL occurred 3 months after the diagnosis of leukemia. It was quite different from the reports in literature that most CNSL usually occurred after complete remission, with CSF routine examination the into cranial pressure, the protein content, the white cell count and the smear for leukemic cells were of significant diagnostic help. Among these, the founding of leukemic cells in the fresh specimen by using natural precipitation method is the most reliable diagnostic criterion of CNSL.
Zhonghua Nei Ke Za Zhi 1989 Feb
PMID:[Clinical analysis of 134 cases of central nervous system leukemia]. 273 44


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