Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for these molecules.
Kinetin riboside
was shown to only act on M4 Beu human and B16 murine melanoma cells at low concentration (1.5 and 0.2 microM). On mice with
leukaemia
P388, this product has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg.
Kinetin riboside
was also shown to have a cytotoxic effect on plant tumour cells (crown-gall).
...
PMID:Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells. 1537 84
