Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The intracellular transformation of cis-mafosfamide has been studied in P388 mice
leukemia
cells using 31P-NMR spectroscopy. For this purpose the cells were entrapped in low-gelling-temperature agarose threads. Internal pH of the cells, determined from the position of the intracellular inorganic phosphate, was 7.2. The cell membrane was permeable to 4-hydroxycyclophosphamide and aldophosphamide and less permeable to phosphoramide mustard.
4-Ketocyclophosphamide
and carboxyphosphamide signals were not detectable in cells either sensitive or resistant to oxazaphosphorine treatment.
...
PMID:Biotransformation of mafosfamide in P388 mice leukemia cells: intracellular 31P-NMR studies. 232 93
