Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0023418 (
leukemia
)
93,477
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The Mixed Lineage
Leukemia
gene (MLL) is altered in
leukemia
by chromosomal translocations to produce oncoproteins composed of the MLL N-terminus fused to the C-terminus of a partner protein. Here, we used domain-focused CRISPR screening to identify
ZFP64
as an essential transcription factor in MLL-rearranged
leukemia
. We show that the critical function of
ZFP64
in
leukemia
is to maintain MLL expression via binding to the MLL promoter, which is the most enriched location of
ZFP64
occupancy in the human genome. The specificity of
ZFP64
for MLL is accounted for by an exceptional density of
ZFP64
motifs embedded within the MLL promoter. These findings demonstrate how a sequence anomaly of an oncogene promoter can impose a transcriptional addiction in cancer.
...
PMID:A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence. 3050 6
