Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The antibody response to Herpesvirus saimiri (HSV)-induced membrane antigens (MA) was followed in HSV-infected owl monkeys using the membrane immunofluorescence (MF) and antibody-dependent lymphocyte cytotoxicity (ADLC) assays. These responses were correlated with the loss of T-cell responsiveness to general mitogens. Antibody titers to MA as determined by ADLC but not MF increased to remarkably high titers in those monkeys that developed malignant disease following virus infection, while remaining at relatively low and constant levels in those monkeys that developed a chronic virus infection in the absence of malignant disease. This disease-related antibody response pattern was paralleled by the loss of T-cell function in diseased animals. The development of leukemia in HVS-infected owl monkeys did not suppress the ability of peripheral blood lymphocytes to act as effector cells in the ADLC assay. The relationship of these immune response patterns to the development of malignant disease in this system is discussed.
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PMID:Antibody responses to membrane antigens in monkeys infected with Herpesvirus saimiri. 18 15

T-lymphocytes from three species of New World monkeys were susceptible to transformation in vitro with human T-cell leukemia virus. Marmoset T-lymphocytes transformed in vitro with HVS or HVA, T-lymphotropic herpesviruses of New World monkeys, were also transformed with HTLV resulting in doubly transformed T-cells. This finding may provide a potential model for investigating the possible interaction between a herpesvirus and T-lymphotropic retroviruses in the clinical condition AIDS.
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PMID:Human T-cell leukemia virus: transformation in vitro of nonhuman primate T-lymphocytes and experimental inoculation of nonhuman primates. 610 10