Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

AKR mice were given sc injections of goat antiviral immune globulin from birth through 14 or 31 days of age. Although the shorter immunization schedule greatly reduced expression of spontaneous leukemia, the longer immunization period was required for essentially complete prevention of leukemia. Immune globulin with a high neutralization titer for ecotropic virus provided this protection, whereas antibody with a high neutralization titer for murine xenotropic virus did not.
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PMID:Prevention of spontaneous leukemia in AKR mice by passive immunization and type specificity of this protection. 21 84

Seventeen children of 2-15 years of age with newly diagnosed untreated acute lymphatic leukaemia (ALL) were evaluated with a number of immunological tests: for humoral immunity serum immunoglobulins and reactive antibody formation against three antigens (diphtheria, tetanus, KLH); for cell-mediated immunity in vitro response of blood lymphocytes against PHA; membrane characteristics of blood lymphocytes and lymphoid blasts for both B and T cells. The tests were repeated in thirteen patients who attained full remission. In the majority (twelve cases) no surface markers were detected (null-cell leukaemia), one patient fulfilled the criteria for a T-cell leukaemia with thymoma. Four patients had rather high absolute B-cell counts, but did not fulfill all the criteria for B-cell leukaemia; three of them died before remission. Immune globulin concentrations were only slightly changed, antibody formation, both primary and anamnestic, was possible. PHA response was extremely low in the initial phase, but normal immediately after remission. During remission all patients were markedly depleted in both their B- and T-cell compartment.
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PMID:Studies on the immune status of children with acute lymphocytic leukaemia. I. Early phase before and after first remission. 108 93