Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 1415 bronchial cancer patients were 84 (5.94%) tonsillectomized observed. In an equal number of controls, selected according to the strictest criteria, there were 265 (18.7%) tonsillectomized. The latter figure corresponds to the lower limit for the frequency of tonsillectomies in the Federal Republic of Germany in the second half of the seventies. Thus these results show that bronchial cancer patients were subjected to tonsillectomy 3 times less than individuals not suffering from bronchial cancer. These results are in perfect agreement with previously obtained findings on the incidence of tonsillectomy in ENT tumors as well as in leukemia in children and adults.
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PMID:[Frequency of tonsillectomy in bronchial cancer patients (author's transl)]. 65 59

Three patients developed severe respiratory syncytial virus pneumonia after bone marrow autograft for acute leukaemia. Clinically, the disease presents as interstitial or bilateral alveolo-interstitial pneumonia with hypoxaemia. Signs of ENT infection (otitis media, sinusitis) are present in 30 percent of the cases. In all 3 patients, the syncytial virus was isolated by direct immunofluorescence in bronchoalveolar lavage fluid. In 2 patients the infection began soon after the autograft, in deeply aplastic subjects, and required intubation and assisted ventilation. These 2 patients died despite inhalation of aerosolized ribavirin combined, in one of them, with ribavirin injections. In the third patient the infection began some time after the autograft and responded well to ribavirin in aerosols. In these three cases the viral infection occurred in an epidemic and nosocomial context. The respiratory syncytial virus is usually transmitted by the hands. Owing to the severity of this infection with lung involvement in immunodepressed patients, specific prophylactic measures should be taken side by side with the conventional measures.
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PMID:[Severe respiratory syncytial virus pneumonia following bone marrow autograft. 3 cases]. 153 59

Antibody to the recently identified hepatitis C virus (HCV) was investigated in sera of 50 leukemic children who had chronic liver disease (CLD), observed for 1 to 12.6 years after therapy withdrawal. All patients were tested for anti-HCV at regular intervals: Ortho-enzyme-linked immunosorbent assay (ELISA) test was performed in all cases. Reactive sera were also tested by recombinant immunoblotting assay to define the specificity of the results obtained by ELISA. Twelve cases (24%) were persistently positive (group A), 11 (22%) were transiently anti-HCV+ positive (group B), and 27 (54%) were negative. Mean SGPT peak during follow-up was significantly higher in group A (P = .014, A v B and P less than .00001, A v C). SGPT normalized off-therapy in 1 of 12 cases (group A), 10 of 11 (group B), and 19 of 27 (group C) (P = .0004, A v B and P = .012, A v C). Accordingly, liver histology, available in 37 patients, showed signs of chronic hepatitis in all patients in group A while most patients in group B and C had less severe liver lesions. These results indicate that HCV plays a significant role in the etiology of chronic hepatitis in leukemic patients and that persistent anti-HCV activity correlates with a more severe CLD, which could jeopardize the final prognosis of children cured of leukemia.
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PMID:Hepatitis C virus infection and chronic liver disease in children with leukemia in long-term remission. 165 63

To clarify the prevalence of concurrent infection with hepatitis C virus (HCV), hepatitis B virus (HBV) and human T cell leukaemia virus (HTLV), we measured HCV antibody in the population of a district endemic for HBV and HTLV infection. Blood samples were collected in June 1990 from 579 inhabitants of four islands of Uwa Bay in the southwest of Ehime Prefecture in Japan. Anti-HCV antibody against C100-3 protein was detected using an enzyme-linked immunosorbent assay kit (Ortho Diagnostics). Thirteen of the 579 inhabitants (2.2%) were positive for anti-HCV, and this prevalence rate was not significantly different from the frequency of anti-HCV in Tokyo blood donors. A total of 11% (64 of 579) of the subjects were positive for HBsAg and 3.3% (19 of 579) were positive for anti-HTLV. These frequencies of HBsAg and anti-HTLV positivity were distinctly higher than the respective means of Japanese. All anti-HCV positive individuals were negative for HBsAg and anti-HTLV, while 54% (7 of 13) had increased alanine aminotransferase levels. These data suggest that the prevalence of HCV infection is not high even in an area endemic for HBV and HTLV infection.
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PMID:Prevalence of hepatitis C virus antibody in an area endemic for hepatitis B virus and human T cell leukaemia virus. 168 26

This retrospective hospital study concerns 159 infectious episodes observed in 60 patients with chronic lymphoid leukaemia (CLL) staged A, B or C on first admission. The most frequent site of infection was pulmonary (33%), followed by ENT and stomatological infections (15%), septicaemia (9%), urinary and genital tracts infections (9%), herpes virus infections (9%), skin and soft tissue purulent sepsis (8%), digestive tract (3%) and meningeal (1%) infections and isolated fever (8%). Seventy nine bacteria were isolated, including 35 Gram-positive cocci (Staphylococcus spp. 12, Streptococcus spp. 13, D. pneumoniae 5, Enterococcus spp. 5), 43 Gram-negative bacilli (Enterobacteriaceae 36, Pseudomonas spp. 5, Haemophilus influenzae 2) and 1 M. tuberculosis. The other documented infections were: candidiasis 11, viral infections 19 (including 17 of the herpes group) and 2 parasitoses (1 pneumocystosis, 1 toxoplasmosis). Sixteen patients died of toxic -infectious shock (9 cases, including 1 meningitis) or pneumonia (7 cases, including one chicken-pox). Stage C leukaemia and granulopenia (less than 1 X 10(9) PN/l) were associated with significantly more frequent and severe infections.
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PMID:[Severe infections associated with chronic lymphoid leukemia. 159 infectious episodes in 60 patients]. 294 30

The underestimation of WBC by the Ortho ELT800/WS cell analyser in some cases of chronic lymphatic leukaemia has been investigated. Incorrect WBC was obtained on 44% of samples. WBC, smear cell count, lymphocyte cell volume, stage of disease and chemotherapy were studied in both discrepant and non-discrepant cases. The evidence suggested that low lymphocyte cell volume was the major cause of the anomaly. The relationship of small lymphocyte cell volume to increased cell density is also discussed.
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PMID:Erroneous Ortho ELT800/WS WBC in chronic lymphatic leukaemia. 344 73

C-type particles produced by a tissue culture-adapted BALB/c myeloma were characterized. It was determined that although the particles were morphologically and antigenically similar to murine leukemia and sarcoma virus, the size of their RNA was different, they lacked RNA-dependent DNA polymerase, they were unstable in NET buffer, sucrose and citrate but were stable in glycerol and Earle balanced salt solution, and they behaved differently from oncornaviruses when treated with ether and detergent.
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PMID:Characterization of C-type particles produced by a tissue culture-adapted murine myeloma. 412 86

Cell kinetics were studied in human leukemia (acute leukemia, chronic myelocytic leukemia and other myelocytic malignancies) and in mouse leukemia (L 1210 cells). Flow cytometry method was employed for the analysis of DNA distribution of cells stained with propidium iodide, using a cytofluorograf (System 50, Ortho Instruments). The DNA per cell frequency distribution histograms (DNA histogram) in normal human lymphocytes from peripheral blood showed one main peak of diploid, which corresponded to the DNA from cells in G1 phase of the cell cycle, and other small portions, which corresponded to the DNA from cells in S, G2 and M compartments (S + G2 + M). The percentage of the number of cells in the S + G2 + M phase to the total cells from normal controls was 2.1%. In the case of untreated acute myelocytic leukemia (AML), the percentages of cells in the S + G2 + M phase from peripheral blood and bone marrow were 2.4% and 7.1%, respectively. In bone marrow from treated AML, the percentage of cells in the S + G2 + M phase increased to 14.8%. In the case of untreated acute lymphocytic leukemia, the percentages of the S + G2 + M phase from peripheral blood and bone marrow were 1.9% and 7.1%, respectively. After the treatment of chronic myelocytic leukemia, the percentages of the S + G2 + M phase in peripheral blood and bone marrow were 5.8% and 12.2%, respectively. The DNA histogram in untreated L 1210 cells showed two peaks. One of the peak was consisted of the DNA from cells in G1 phase and another was from cells in the S + G2 + M phase. The proportion of the S + G2 + M phase in the L 1210 cells treated with antitumor drugs significantly increased compared to the untreated cells. The findings indicate that the increase in the proportion of the S + G2 + M phase in the cells from treated human leukemia was a result of the therapeutic effects of antitumor drugs. The study of cell kinetics may provide benefits to know the effect of antitumor drugs during the treatment of human leukemia.
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PMID:[Studies on cell kinetics in leukemia using flow cytometry]. 715 63

The Third International Symposium on Immunotoxins was held on June 19-21, 1992 in Orlando, Florida. This symposium was sponsored by NATO, NIH, Pierce Chemical Company, Walt Disney Cancer Institute at Florida Hospital, Duke Comprehensive Cancer Center, Xoma, Immunogen, Seragen, Bristol-Myers Squibb, Chiron, Ortho Biotech, Upjohn, Merck Sharp & Dohme Research Laboratories, Abbot Laboratories, Lilly Research Laboratories, and Evans & Sutherland. The Pierce Immunotoxin Award which recognizes outstanding contributions to immunotoxin research and development, was presented to Drs David FitzGerald, Fatih Uckun, David Eisenberg, and Ira Wool, for their contributions to the immunotoxin field.
Leukemia 1993 Feb
PMID:The current status of immunotoxins: an overview of experimental and clinical studies as presented at the Third International Symposium on Immunotoxins. 809 12

Intracellular antigens are of major importance for immunophenotyping of normal leukocytes as well as leukemias and malignant lymphomas. Immunofluorescence microscopic evaluation of cytocentrifuge preparations has remained the preferred technique for detection of intracellular antigens for a long time. Recently, flow cytometric detection of intracellular antigens has been improved by the development of new permeabilization/fixation solutions. We compared four commercially available solutions: FACS Brand Lysing Solution (FACS Brand; Becton Dickinson, San Jose, CA, USA), Fix & Perm cell permeabilization kit (Fix & Perm; An der Grub, Vienna, Austria), OptiLyse B lysing solution (OptiLyse B; Immunotech, Marseille, France), and ORTHO PermeaFix(PermeaFix; Ortho Diagnostic Systems, Raritan, NJ, USA). These solutions were evaluated for the complexity and duration of the intracellular staining procedure, the effects on light scatter patterns, and the staining results for the intracellular antigens terminal deoxynucleotidyl transferase (TdT), cytoplasmic CD3 (CyCD3), myeloperoxidase (MPO), and cytoplasmic immunoglobulin light chains (CylgL). The four methods could easily be introduced in our laboratory and had only minor effect on the light scatter patterns of the tested cell samples. Each of the four tested antigens was detectable with at least one of the four methods. Only the Fix & Perm cell permeabilization kit could be used for reliable detection of all four intracellular antigens. In a large series of 450 BM and PB samples containing various percentages of TdT+ cells, the results of flow cytometric TdT staining with FACS Brand Lysing Solution were highly comparable to the results obtained by immunofluorescence microscopy (P = <0.00001). Our comparative study shows that flow cytometric detection of the intracellular antigens TdT, CyCD3, MPO, and CylgL can now reliably be performed on a routine basis.
Leukemia 1996 Aug
PMID:Flow cytometric detection of intracellular antigens for immunophenotyping of normal and malignant leukocytes. 870 49


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