Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Levamisole, a widely used antihelminthic drug has been shown to restore cutaneous delayed hypersensitivity in anergic patients with cancer and to amplify the activation of T lymphocytes by in vitro mitogens. Levamisole has been approved for the treatment of colon cancer in combination with 5 Fluorouracil. Herein we report a case of a 5 1/2 y.o. male who presented with a fulminant, disseminated mycobacterial infection of his joints secondary to a deficiency in his cellular mediated immunity in association with chemotherapy for a T cell leukemia. The patient was treated with Levamisole resulting in restoration of his T cell functions and resolution of his mycobacterial infection.
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PMID:Levamisole as an immunopotentiator for T cell deficiency. 807 2