Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0023418 (leukemia)
 93,477 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

As chemotherapy has become more effective, patterns of relapse have begun to change. We report a patient with T-cell acute lymphoblastic leukemia (ALL) who had an isolated mandibular relapse that was first manifested as dental pain. Eight other recently reported patients with acute leukemia who relapsed in the mandible are reviewed. In four the relapse was isolated to the mandible; all four had ALL. Local control of disease was achieved with radiotherapy, often combined with chemotherapy. However, our patient and two of the other four subsequently relapsed and died of refractory leukemia.
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PMID:Mandibular relapse in acute leukemia. Report of a case. 349 Jan 89

Arsenic trioxide in the treatment of acute promyelocytic leukaemia is relatively safe with minimal side effects. Dental toxicities associated with its use are uncommon. We describe the first case report of toothache associated with arsenic trioxide. A 45-year-old male with relapsed APL was commenced on a treatment schedule of all-trans-retinoic acid 20mg four times a day for 14 days concurrent with a 10mg intravenous infusion of arsenic trioxide for 28 days. After 14 doses of the 6th cycle of treatment he experienced severe acute pain in various parts of the oral cavity. Extensive examination including an orthodontic review concluded there was no indication that the pain symptoms were due to a dental or endodontic cause. Four days after completing his 6th cycle the pain completely resolved. The mechanism of this adverse event remains unclear. Physicians with patients receiving arsenic trioxide with unexplained toothache should consider the arsenic as the cause of the pain.
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PMID:Arsenic trioxide associated toothache. 1952 3